KM Hannan
KM Hannan
John Curtin School of Medical Research
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mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar …
KM Hannan, Y Brandenburger, A Jenkins, K Sharkey, A Cavanaugh, ...
Molecular and cellular biology 23 (23), 8862-8877, 2003
Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function
K Jastrzebski, KM Hannan, EB Tchoubrieva, RD Hannan, RB Pearson
Growth factors 25 (4), 209-226, 2007
AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy
MV Astle, KM Hannan, PY Ng, RS Lee, AJ George, AK Hsu, Y Haupt, ...
Oncogene 31 (15), 1949-1962, 2012
Targeting the nucleolus for cancer intervention
JE Quin, JR Devlin, D Cameron, KM Hannan, RB Pearson, RD Hannan
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842 (6), 802-816, 2014
MAD1 and c‐MYC regulate UBF and rDNA transcription during granulocyte differentiation
G Poortinga, KM Hannan, H Snelling, CR Walkley, A Jenkins, K Sharkey, ...
The EMBO journal 23 (16), 3325-3335, 2004
UBF levels determine the number of active ribosomal RNA genes in mammals
E Sanij, G Poortinga, K Sharkey, S Hung, TP Holloway, J Quin, E Robb, ...
Journal of Cell Biology 183 (7), 1259-1274, 2008
The nucleolus: an emerging target for cancer therapy
N Hein, KM Hannan, AJ George, E Sanij, RD Hannan
Trends in molecular medicine 19 (11), 643-654, 2013
Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1
KM Hannan, RD Hannan, SD Smith, LS Jefferson, M Lun, LI Rothblum
Oncogene 19 (43), 4988-4999, 2000
Transcription by RNA polymerase I
KM Hannan, RD Hannan, LI Rothblum
Front Biosci 3, d376-d398, 1998
Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase
NM Conus, KM Hannan, BE Cristiano, BA Hemmings, RB Pearson
Journal of Biological Chemistry 277 (41), 38021-38028, 2002
AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer
JC Chan, KM Hannan, K Riddell, PY Ng, A Peck, RS Lee, S Hung, ...
Science signaling 4 (188), ra56-ra56, 2011
The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy
SJ Woods, KM Hannan, RB Pearson, RD Hannan
Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1849 (7), 821-829, 2015
Dysregulation of RNA polymerase I transcription during disease
KM Hannan, E Sanij, LI Rothblum, RD Hannan, RB Pearson
Biochimica Et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1829 (3-4 …, 2013
A specific role for AKT3 in the genesis of ovarian cancer through modulation of G2-M phase transition
BE Cristiano, JC Chan, KM Hannan, NA Lundie, NJ Marmy-Conus, ...
Cancer Research 66 (24), 11718-11725, 2006
RNA polymerase I transcription in confluent cells: Rb downregulates rDNA transcription during confluence-induced cell cycle arrest
KM Hannan, BK Kennedy, AH Cavanaugh, RD Hannan, ...
Oncogene 19 (31), 3487-3497, 2000
Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation
M Wall, G Poortinga, KM Hannan, RB Pearson, RD Hannan, GA McArthur
Blood, The Journal of the American Society of Hematology 112 (6), 2305-2317, 2008
Combination therapy targeting ribosome biogenesis and mRNA translation synergistically extends survival in MYC-driven lymphoma
JR Devlin, KM Hannan, N Hein, C Cullinane, E Kusnadi, PY Ng, ...
Cancer discovery 6 (1), 59-70, 2016
Diabetes-Induced Vascular Hypertrophy Is Accompanied by Activation of Na+-H+ Exchange and Prevented by Na+-H+ Exchange Inhibition
K Jandeleit-Dahm, KM Hannan, CA Farrelly, TJ Allen, JR Rumble, ...
Circulation research 87 (12), 1133-1140, 2000
Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors
KE Sheppard, C Cullinane, KM Hannan, M Wall, J Chan, F Barber, J Foo, ...
European journal of cancer 49 (18), 3936-3944, 2013
Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas
J Shortt, BP Martin, A Newbold, KM Hannan, JR Devlin, AJ Baker, R Ralli, ...
Blood 121 (15), 2964-2974, 2013
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Artikelen 1–20