| Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease RS Doody, RG Thomas, M Farlow, T Iwatsubo, B Vellas, S Joffe, ... New England Journal of Medicine 370 (4), 311-321, 2014 | 1741 | 2014 |
| Trial of solanezumab for mild dementia due to Alzheimer’s disease LS Honig, B Vellas, M Woodward, M Boada, R Bullock, M Borrie, K Hager, ... New England Journal of Medicine 378 (4), 321-330, 2018 | 949 | 2018 |
| HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin A Iwata, BE Riley, JA Johnston, RR Kopito Journal of Biological Chemistry 280 (48), 40282-40292, 2005 | 856 | 2005 |
| Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation A Iwata, JC Christianson, M Bucci, LM Ellerby, N Nukina, LS Forno, ... Proceedings of the National Academy of Sciences 102 (37), 13135-13140, 2005 | 371 | 2005 |
| CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's disease L Matsumoto, H Takuma, A Tamaoka, H Kurisaki, H Date, S Tsuji, A Iwata PloS one 5 (11), e15522, 2010 | 352 | 2010 |
| Noncoding CGG repeat expansions in neuronal intranuclear inclusion disease, oculopharyngodistal myopathy and an overlapping disease H Ishiura, S Shibata, J Yoshimura, Y Suzuki, W Qu, K Doi, MA Almansour, ... Nature genetics 51 (8), 1222-1232, 2019 | 306 | 2019 |
| Mutations in COQ2 in Familial and Sporadic Multiple-System Atrophy Multiple-System Atrophy Research Collaboration New England Journal of Medicine 369 (3), 233-244, 2013 | 257 | 2013 |
| Mutations for Gaucher disease confer high susceptibility to Parkinson disease J Mitsui, I Mizuta, A Toyoda, R Ashida, Y Takahashi, J Goto, Y Fukuda, ... Archives of neurology 66 (5), 571-576, 2009 | 242 | 2009 |
| IFNβ-1b may severely exacerbate Japanese optic-spinal MS in neuromyelitis optica spectrum J Shimizu, Y Hatanaka, M Hasegawa, A Iwata, I Sugimoto, H Date, J Goto, ... Neurology 75 (16), 1423-1427, 2010 | 238 | 2010 |
| Association of factors with elevated amyloid burden in clinically normal older individuals RA Sperling, MC Donohue, R Raman, CK Sun, R Yaari, K Holdridge, ... JAMA neurology 77 (6), 735-745, 2020 | 204 | 2020 |
| Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies A Iwata, M Maruyama, T Akagi, T Hashikawa, I Kanazawa, S Tsuji, ... Human molecular genetics 12 (20), 2625-2635, 2003 | 196 | 2003 |
| α-Synuclein affects the MAPK pathway and accelerates cell death A Iwata, M Maruyama, I Kanazawa, N Nukina Journal of Biological Chemistry 276 (48), 45320-45329, 2001 | 191 | 2001 |
| Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial M Katsuno, H Banno, K Suzuki, Y Takeuchi, M Kawashima, I Yabe, ... The Lancet Neurology 9 (9), 875-884, 2010 | 187 | 2010 |
| Altered CpG methylation in sporadic Alzheimer's disease is associated with APP and MAPT dysregulation A Iwata, K Nagata, H Hatsuta, H Takuma, M Bundo, K Iwamoto, ... Human molecular genetics 23 (3), 648-656, 2014 | 147 | 2014 |
| α‐Synuclein forms a complex with transcription factor Elk‐1 A Iwata, S Miura, I Kanazawa, M Sawada, N Nukina Journal of neurochemistry 77 (1), 239-252, 2001 | 137 | 2001 |
| Variants associated with Gaucher disease in multiple system atrophy J Mitsui, T Matsukawa, H Sasaki, I Yabe, M Matsushima, A Dürr, A Brice, ... Annals of clinical and translational neurology 2 (4), 417-426, 2015 | 125 | 2015 |
| The TRK-fused gene is mutated in hereditary motor and sensory neuropathy with proximal dominant involvement H Ishiura, W Sako, M Yoshida, T Kawarai, O Tanabe, J Goto, Y Takahashi, ... The American Journal of Human Genetics 91 (2), 320-329, 2012 | 121 | 2012 |
| Accumulation of phosphorylated α‐synuclein in dopaminergic neurons of transgenic mice that express human α‐synuclein M Wakamatsu, A Ishii, Y Ukai, J Sakagami, S Iwata, M Ono, K Matsumoto, ... Journal of neuroscience research 85 (8), 1819-1825, 2007 | 114 | 2007 |
| Intranuclear degradation of polyglutamine aggregates by the ubiquitin-proteasome system A Iwata, Y Nagashima, L Matsumoto, T Suzuki, T Yamanaka, H Date, ... Journal of Biological Chemistry 284 (15), 9796-9803, 2009 | 109 | 2009 |
| Early detection of mild cognitive impairment (MCI) in primary care MN Sabbagh, M Boada, S Borson, M Chilukuri, B Dubois, J Ingram, ... The Journal of prevention of Alzheimer's disease 7, 165-170, 2020 | 107 | 2020 |
Takeshi IwatsuboProfessor of Neuropathology, The University of TokyoGeverifieerd e-mailadres voor m.u-tokyo.ac.jp
