Nabil Seidah
Nabil Seidah
Geverifieerd e-mailadres voor ircm.qc.ca
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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
M Abifadel, M Varret, JP Rabès, D Allard, K Ouguerram, M Devillers, ...
Nature genetics 34 (2), 154-156, 2003
27972003
Chloroquine is a potent inhibitor of SARS coronavirus infection and spread
MJ Vincent, E Bergeron, S Benjannet, BR Erickson, PE Rollin, TG Ksiazek, ...
Virology journal 2 (1), 1-10, 2005
15862005
The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation
NG Seidah, S Benjannet, L Wickham, J Marcinkiewicz, SB Jasmin, ...
Proceedings of the National Academy of Sciences 100 (3), 928-933, 2003
11932003
The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade
B Coutard, C Valle, X de Lamballerie, B Canard, NG Seidah, E Decroly
Antiviral research 176, 104742, 2020
10432020
The Notch1 receptor is cleaved constitutively by a furin-like convertase
F Logeat, C Bessia, C Brou, O LeBail, S Jarriault, NG Seidah, A Israël
Proceedings of the National Academy of Sciences 95 (14), 8108-8112, 1998
9451998
Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides
NG Seidah, M Chrétien
Brain research 848 (1-2), 45-62, 1999
8611999
PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues.
S Benjannet, N Rondeau, R Day, M Chretien, NG Seidah
Proceedings of the National Academy of Sciences 88 (9), 3564-3568, 1991
7291991
NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol
S Benjannet, D Rhainds, R Essalmani, J Mayne, L Wickham, W Jin, ...
Journal of Biological Chemistry 279 (47), 48865-48875, 2004
6582004
Statins Upregulate PCSK9, the Gene Encoding the Proprotein Convertase Neural Apoptosis-Regulated Convertase-1 Implicated in Familial Hypercholesterolemia
G Dubuc, A Chamberland, H Wassef, J Davignon, NG Seidah, L Bernier, ...
Arteriosclerosis, thrombosis, and vascular biology 24 (8), 1454-1459, 2004
6482004
The biology and therapeutic targeting of the proprotein convertases
NG Seidah, A Prat
Nature reviews Drug discovery 11 (5), 367-383, 2012
6382012
Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor
SJ Mowla, HF Farhadi, S Pareek, JK Atwal, SJ Morris, NG Seidah, ...
Journal of Biological Chemistry 276 (16), 12660-12666, 2001
6132001
Automated design of ligands to polypharmacological profiles
J Besnard, GF Ruda, V Setola, K Abecassis, RM Rodriguiz, XP Huang, ...
Nature 492 (7428), 215-220, 2012
5992012
cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases
NG Seidah, L Gaspar, P Mion, M Marcinkiewicz, M Mbikay, M Chretien
DNA and cell biology 9 (6), 415-424, 1990
5791990
Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution …
NG Seidah, M Marcinkiewicz, S Benjannet, L Gaspar, G Beaubien, ...
Molecular Endocrinology 5 (1), 111-122, 1991
5211991
The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions
NG Seidah, M Chretien, R Day
Biochimie 76 (3-4), 197-209, 1994
4671994
PCSK9: a key modulator of cardiovascular health
NG Seidah, Z Awan, M Chrétien, M Mbikay
Circulation research 114 (6), 1022-1036, 2014
4542014
The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2
S Poirier, G Mayer, S Benjannet, E Bergeron, J Marcinkiewicz, ...
Journal of Biological Chemistry 283 (4), 2363-2372, 2008
4202008
Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases
NG Seidah, S Benjannet, S Pareek, M Chrétien, RA Murphy
FEBS letters 379 (3), 247-250, 1996
4071996
Delta-1 Activation of Notch-1 Signaling Results inHES-1 Transactivation
S Jarriault, O Le Bail, E Hirsinger, O Pourquié, F Logeat, CF Strong, ...
Molecular and cellular biology 18 (12), 7423-7431, 1998
3931998
Differential sorting of nerve growth factor and brain-derived neurotrophic factor in hippocampal neurons
SJ Mowla, S Pareek, HF Farhadi, K Petrecca, JP Fawcett, NG Seidah, ...
Journal of Neuroscience 19 (6), 2069-2080, 1999
3831999
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Artikelen 1–20