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Jennifer J. Trowbridge
Jennifer J. Trowbridge
Assistant Professor, The Jackson Laboratory
Geverifieerd e-mailadres voor jax.org
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DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells
JJ Trowbridge, JW Snow, J Kim, SH Orkin
Cell stem cell 5 (4), 442-449, 2009
4152009
Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation
JJ Trowbridge, A Xenocostas, RT Moon, M Bhatia
Nature medicine 12 (1), 89-98, 2006
3042006
Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease
A Burberry, N Suzuki, JY Wang, R Moccia, DA Mordes, MH Stewart, ...
Science translational medicine 8 (347), 347ra93-347ra93, 2016
2772016
Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A
J Xu, DE Bauer, MA Kerenyi, TD Vo, S Hou, YJ Hsu, H Yao, JJ Trowbridge, ...
Proceedings of the National Academy of Sciences 110 (16), 6518-6523, 2013
2572013
Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration
JJ Trowbridge, MP Scott, M Bhatia
Proceedings of the National Academy of Sciences 103 (38), 14134-14139, 2006
2322006
Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains
JJ Trowbridge, AU Sinha, N Zhu, M Li, SA Armstrong, SH Orkin
Genes & development 26 (4), 344-349, 2012
1452012
Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS
JJ Trowbridge, DT Starczynowski
Journal of Experimental Medicine 218 (7), e20201544, 2021
1032021
Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging
K Young, E Eudy, R Bell, MA Loberg, T Stearns, D Sharma, L Velten, ...
Cell stem cell 28 (8), 1473-1482. e7, 2021
962021
The lethal sex gap: COVID-19
EJ Márquez, J Trowbridge, GA Kuchel, J Banchereau, D Ucar
Immunity & Ageing 17, 1-8, 2020
962020
Sequentially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesis
MA Loberg, RK Bell, LO Goodwin, E Eudy, LA Miles, JM SanMiguel, ...
Leukemia 33 (7), 1635-1649, 2019
932019
Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging
K Young, S Borikar, R Bell, L Kuffler, V Philip, JJ Trowbridge
Journal of Experimental Medicine 213 (11), 2259-2267, 2016
902016
Hierarchical and ontogenic positions serve to define the molecular basis of human hematopoietic stem cell behavior
F Shojaei, J Trowbridge, L Gallacher, L Yuefei, D Goodale, F Karanu, ...
Developmental cell 8 (5), 651-663, 2005
822005
Context-dependent function of “GATA switch” sites in vivo
JW Snow, JJ Trowbridge, KD Johnson, T Fujiwara, NE Emambokus, ...
Blood, The Journal of the American Society of Hematology 117 (18), 4769-4772, 2011
642011
A Single cis Element Maintains Repression of the Key Developmental Regulator Gata2
JW Snow, JJ Trowbridge, T Fujiwara, NE Emambokus, JA Grass, ...
PLoS genetics 6 (9), e1001103, 2010
642010
Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells
J George, A Uyar, K Young, L Kuffler, K Waldron-Francis, E Marquez, ...
Nature communications 7 (1), 12166, 2016
572016
A unique population of bone marrow cells migrates to skeletal muscle via hepatocyte growth factor/c-met axis
M Rosu-Myles, E Stewart, J Trowbridge, CY Ito, P Zandstra, M Bhatia
Journal of cell science 118 (19), 4343-4352, 2005
492005
Hand in hand: intrinsic and extrinsic drivers of aging and clonal hematopoiesis
JM SanMiguel, K Young, JJ Trowbridge
Experimental hematology 91, 1-9, 2020
472020
Dnmt3a silences hematopoietic stem cell self-renewal
JJ Trowbridge, SH Orkin
Nature genetics 44 (1), 13-14, 2012
472012
Actinomycin D targets NPM1c-primed mitochondria to restore PML-driven senescence in AML therapy
HC Wu, D Rérolle, C Berthier, R Hleihel, T Sakamoto, S Quentin, ...
Cancer discovery 11 (12), 3198-3213, 2021
422021
Hematopoietic stem cell biology: too much of a Wnt thing
JJ Trowbridge, RT Moon, M Bhatia
Nature immunology 7 (10), 1021-1023, 2006
422006
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Artikelen 1–20