| Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria GA Biagini, N Fisher, AE Shone, MA Mubaraki, A Srivastava, A Hill, ... Proceedings of the National Academy of Sciences 109 (21), 8298-8303, 2012 | 192 | 2012 |
| Identification of a 1, 2, 4, 5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins PM O'Neill, RK Amewu, GL Nixon, F BousejraElGarah, M Mungthin, ... Angewandte Chemie-International Edition 49 (33), 5693, 2010 | 169 | 2010 |
| Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs PA Stocks, PG Bray, VE Barton, M Al-Helal, M Jones, NC Araujo, ... Angewandte Chemie-International Edition 46 (33), 6278-6283, 2007 | 168 | 2007 |
| Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential T Antoine, N Fisher, R Amewu, PM O'Neill, SA Ward, GA Biagini Journal of antimicrobial chemotherapy 69 (4), 1005-1016, 2014 | 149 | 2014 |
| Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2) C Pidathala, R Amewu, B Pacorel, GL Nixon, P Gibbons, WD Hong, ... Journal of medicinal chemistry 55 (5), 1831-1843, 2012 | 129 | 2012 |
| Design and synthesis of orally active dispiro 1, 2, 4, 5-tetraoxanes; synthetic antimalarials with superior activity to artemisinin R Amewu, AV Stachulski, SA Ward, NG Berry, PG Bray, J Davies, G Labat, ... Organic & biomolecular chemistry 4 (24), 4431-4436, 2006 | 114 | 2006 |
| Two-step synthesis of achiral dispiro-1, 2, 4, 5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles GL Ellis, R Amewu, S Sabbani, PA Stocks, A Shone, D Stanford, ... Journal of medicinal chemistry 51 (7), 2170-2177, 2008 | 107 | 2008 |
| Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2) SC Leung, P Gibbons, R Amewu, GL Nixon, C Pidathala, WD Hong, ... Journal of medicinal chemistry 55 (5), 1844-1857, 2012 | 69 | 2012 |
| A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance PM O’Neill, RK Amewu, SA Charman, S Sabbani, NF Gnädig, J Straimer, ... Nature Communications 8 (1), 15159, 2017 | 67 | 2017 |
| Comparison of the reactivity of antimalarial 1, 2, 4, 5-tetraoxanes with 1, 2, 4-trioxolanes in the presence of ferrous iron salts, heme, and ferrous iron salts/phosphatidylcholine F Bousejra-El Garah, MHL Wong, RK Amewu, S Muangnoicharoen, ... Journal of medicinal chemistry 54 (19), 6443-6455, 2011 | 62 | 2011 |
| Novel endoperoxide-based transmission-blocking antimalarials with liver-and blood-schizontocidal activities D Miranda, R Capela, IS Albuquerque, P Meireles, I Paiva, F Nogueira, ... ACS medicinal chemistry letters 5 (2), 108-112, 2014 | 51 | 2014 |
| Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis WD Hong, PD Gibbons, SC Leung, R Amewu, PA Stocks, A Stachulski, ... Journal of medicinal chemistry 60 (9), 3703-3726, 2017 | 48 | 2017 |
| An Endoperoxide‐Based Hybrid Approach to Deliver Falcipain Inhibitors Inside Malaria Parasites R Oliveira, AS Newton, RC Guedes, D Miranda, RK Amewu, A Srivastava, ... ChemMedChem 8 (9), 1528-1536, 2013 | 42 | 2013 |
| Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity P Gibbons, E Verissimo, NC Araujo, V Barton, GL Nixon, RK Amewu, ... Journal of medicinal chemistry 53 (22), 8202-8206, 2010 | 40 | 2010 |
| Second generation analogues of RKA182: synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities F Marti, J Chadwick, RK Amewu, H Burrell-Saward, A Srivastava, ... MedChemComm 2 (7), 661-665, 2011 | 38 | 2011 |
| An efficient route into synthetically challenging bridged achiral 1, 2, 4, 5-tetraoxanes with antimalarial activity GL Ellis, R Amewu, C Hall, K Rimmer, SA Ward, PM O’Neill Bioorganic & medicinal chemistry letters 18 (5), 1720-1724, 2008 | 34 | 2008 |
| Identification of novel antimalarial chemotypes via chemoinformatic compound selection methods for a high-throughput screening program against the novel malarial target, PfNDH2 … R Sharma, AS Lawrenson, NE Fisher, AJ Warman, AE Shone, A Hill, ... Journal of medicinal chemistry 55 (7), 3144-3154, 2012 | 32 | 2012 |
| Antimalarial mannoxanes: hybrid antimalarial drugs with outstanding oral activity profiles and a potential dual mechanism of action J Chadwick, RK Amewu, F Marti, FBE Garah, R Sharma, NG Berry, ... ChemMedChem 6 (8), 1357-1361, 2011 | 30 | 2011 |
| Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers RK Amewu, J Chadwick, A Hussain, S Panda, R Rinki, O Janneh, ... Bioorganic & medicinal chemistry 21 (23), 7392-7397, 2013 | 26 | 2013 |
| Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1, 2, 4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of … R Amewu, P Gibbons, A Mukhtar, AV Stachulski, SA Ward, C Hall, ... Organic & biomolecular chemistry 8 (9), 2068-2077, 2010 | 21 | 2010 |
