| Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells C Cao, T Subhawong, JM Albert, KW Kim, L Geng, KR Sekhar, YJ Gi, B Lu Cancer research 66 (20), 10040-10047, 2006 | 401 | 2006 |
| Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation F Hong, KR Sekhar, ML Freeman, DC Liebler Journal of Biological Chemistry 280 (36), 31768-31775, 2005 | 383 | 2005 |
| Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3 L Gao, J Wang, KR Sekhar, H Yin, NF Yared, SN Schneider, S Sasi, ... Journal of Biological Chemistry 282 (4), 2529-2537, 2007 | 352 | 2007 |
| Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3 G Rachakonda, Y Xiong, KR Sekhar, SL Stamer, DC Liebler, ML Freeman Chemical research in toxicology 21 (3), 705-710, 2008 | 239 | 2008 |
| Binding of tritiated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency, specificity, heterogeneity, and cGMP stimulation MA Blount, A Beasley, R Zoraghi, KR Sekhar, EP Bessay, SH Francis, ... Molecular Pharmacology 66 (1), 144-152, 2004 | 232 | 2004 |
| Cysteine-based regulation of the CUL3 adaptor protein Keap1 KR Sekhar, G Rachakonda, ML Freeman Toxicology and applied pharmacology 244 (1), 21-26, 2010 | 191 | 2010 |
| Increased expression of nuclear factor E2 p45‐related factor 2 (NRF2) in head and neck squamous cell carcinomas DR Stacy, K Ely, PP Massion, WG Yarbrough, DE Hallahan, KR Sekhar, ... Head & Neck: Journal for the Sciences and Specialties of the Head and Neck …, 2006 | 168 | 2006 |
| Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2 KR Sekhar, XX Yan, ML Freeman Oncogene 21 (44), 6829-6834, 2002 | 168 | 2002 |
| Proteins containing non‐native disulfide bonds generated by oxidative stress can act as signals for the induction of the heat shock response AT McDuffee, G Senisterra, S Huntley, JR Lepock, KR Sekhar, ... Journal of cellular physiology 171 (2), 143-151, 1997 | 157 | 1997 |
| Multi‐faceted regulation of γ‐glutamylcysteine synthetase SR Soltaninassab, KR Sekhar, MJ Meredith, ML Freeman Journal of cellular physiology 182 (2), 163-170, 2000 | 143 | 2000 |
| Smad3–ATF3 signaling mediates TGF-β suppression of genes encoding Phase II detoxifying proteins AV Bakin, NV Stourman, KR Sekhar, C Rinehart, X Yan, MJ Meredith, ... Free Radical Biology and Medicine 38 (3), 375-387, 2005 | 135 | 2005 |
| Activating transcription factor 3 is a novel repressor of the nuclear factor erythroid-derived 2–related factor 2 (Nrf2)–regulated stress pathway SL Brown, KR Sekhar, G Rachakonda, S Sasi, ML Freeman Cancer research 68 (2), 364-368, 2008 | 124 | 2008 |
| NADPH oxidase activity is essential for Keap1/Nrf2-mediated induction of GCLC in response to 2-indol-3-yl-methylenequinuclidin-3-ols KR Sekhar, PA Crooks, VN Sonar, DB Friedman, JY Chan, MJ Meredith, ... Cancer research 63 (17), 5636-5645, 2003 | 117 | 2003 |
| Relaxation of Pig Coronary Arteries by New and Potent cGMP Analogs that Selectively Activate Type Ia, Compared with Type lfl, cGMP-Dependent Protein Kinase KR Sekhar, SH FRANCIS, JN WELLS Molecular pharmacology 42, 103-108, 1992 | 115 | 1992 |
| Increased cell migration and plasticity in Nrf2-deficient cancer cell lines G Rachakonda, KR Sekhar, D Jowhar, PC Samson, JP Wikswo, ... Oncogene 29 (25), 3703-3714, 2010 | 106 | 2010 |
| Nrf2 promotes survival following exposure to ionizing radiation KR Sekhar, ML Freeman Free Radical Biology and Medicine 88, 268-274, 2015 | 105 | 2015 |
| Expression of glutathione and γ-glutamylcysteine synthetase mRNA is Jun dependent KR Sekhar, MJ Meredith, LD Kerr, SR Soltaninassab, DR Spitz, ZQ Xu, ... Biochemical and biophysical research communications 234 (3), 588-593, 1997 | 100 | 1997 |
| Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of γ-glutamylcysteine synthetase KR Sekhar, DR Spitz, S Harris, TT Nguyen, MJ Meredith, JT Holt, D Guis, ... Free Radical Biology and Medicine 32 (7), 650-662, 2002 | 94 | 2002 |
| High biochemical selectivity of tadalafil, sildenafil and vardenafil for human phosphodiesterase 5A1 (PDE5) over PDE11A4 suggests the absence of PDE11A4 cross-reaction in patients JL Weeks, R Zoraghi, A Beasley, KR Sekhar, SH Francis, JD Corbin International journal of impotence research 17 (1), 5-9, 2005 | 81 | 2005 |
| Inhibition of cyclic nucleotide phosphodiesterases by methylxanthines and related compounds BB Fredholm, SH Francis, KR Sekhar, H Ke, JD Corbin Methylxanthines, 93-133, 2011 | 79 | 2011 |
