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Francesca Rossiello
Francesca Rossiello
Staff scientist at the FIRC Institute of Molecular Oncology Foundation (IFOM), Milan
Geverifieerd e-mailadres voor ifom.eu
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Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation
M Fumagalli, F Rossiello, M Clerici, S Barozzi, D Cittaro, JM Kaplunov, ...
Nature cell biology 14 (4), 355-365, 2012
8872012
Telomere dysfunction in ageing and age-related diseases
F Rossiello, D Jurk, JF Passos, F d’Adda di Fagagna
Nature Cell Biology 24 (2), 135-147, 2022
2632022
Stable cellular senescence is associated with persistent DDR activation
M Fumagalli, F Rossiello, C Mondello, FA di Fagagna
PloS one 9 (10), e110969, 2014
1692014
Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing
F Rossiello, U Herbig, MP Longhese, M Fumagalli, FA di Fagagna
Current opinion in genetics & development 26, 89-95, 2014
1462014
Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome
J Aguado, A Sola-Carvajal, V Cancila, G Revêchon, PF Ong, ...
Nature communications 10 (1), 4990, 2019
1032019
DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs
F Rossiello, J Aguado, S Sepe, F Iannelli, Q Nguyen, S Pitchiaya, ...
Nature communications 8, 13980, 2017
1012017
From “Cellular” RNA to “Smart” RNA: Multiple Roles of RNA in Genome Stability and Beyond
F Michelini, AP Jalihal, S Francia, C Meers, ZT Neeb, F Rossiello, U Gioia, ...
Chemical reviews 118 (8), 4365-4403, 2018
832018
Identification of fifteen novel germline variants in the BRCA1 3′ UTR reveals a variant in a breast cancer case that introduces a functional miR‐103 target site
BL Brewster, F Rossiello, JD French, SL Edwards, M Wong, A Wronski, ...
Human mutation 33 (12), 1665-1675, 2012
622012
Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury
AK Uryga, MOJ Grootaert, AM Garrido, S Oc, K Foote, J Chappell, ...
Communications Biology 4 (1), 611, 2021
352021
DNA damage response at telomeres boosts the transcription of SARS‐CoV‐2 receptor ACE2 during aging
S Sepe, F Rossiello, V Cancila, F Iannelli, V Matti, G Cicio, M Cabrini, ...
EMBO reports 23 (2), e53658, 2022
302022
Target-enrichment sequencing for detailed characterization of small RNAs
Q Nguyen, J Aguado, F Iannelli, AM Suzuki, F Rossiello, ...
Nature protocols 13 (4), 768-786, 2018
92018
RNase A treatment and reconstitution with DNA damage response RNA in living cells as a tool to study the role of non-coding RNA in the formation of DNA damage response foci
F Michelini, F Rossiello, F d’Adda di Fagagna, S Francia
Nature Protocols 14 (5), 1489-1508, 2019
82019
ImmunoFISH for Adherent Cultured Mammalian Cells
F Rossiello, M Fumagalli, FA di Fagagna
Bio-protocol 3 (24), e999-e999, 2013
12013
Alternative lengthening of telomeres (ALT) cells viability is dependent on C-rich telomeric RNAs
I Rosso, C Jones-Weinert, F Rossiello, M Cabrini, S Brambillasca, ...
Nature Communications 14 (1), 7086, 2023
2023
P1327: INHIBITING TELOMERIC DNA DAMAGE RESPONSE AS A NEW THERAPEUTIC STRATEGY TO REJUVENATE THE AGEING HEMATOPOIETIC SYSTEM
A Oppezzo, S Sepe, F Rossiello, A Conti, E Marinelli, S Boggio, ADI Lillo, ...
HemaSphere 7 (S3), e6000984, 2023
2023
Therapeutic oligonucleotides
FDA Di Fagagna, F Rossiello, J Aguado, C Jones-Weinert
US Patent App. 17/065,409, 2021
2021
RNA products and uses thereof
FDA Di Fagagna, S Francia, F Michelini, F Rossiello
US Patent 10,240,154, 2019
2019
Therapeutic oligonucleotides
FDA Di Fagagna, F Rossiello, J Aguado, C Jones-Weinert
US Patent App. 15/748,133, 2018
2018
STUDY ON THE GENETIC PREDISPOSITION TO BREAST CANCER AND THE DNA DAMAGE RESPONSE AT TELOMERES AND IN CELLULAR SENESCENCE
F Rossiello
Istituto Lombardo-Accademia di Scienze e Lettere-Rendiconti di Scienze, 2016
2016
PERSISTENT DNA DAMAGE AT TELOMERES, CAUSED BY TRF2-MEDIATED DNA REPAIR INHIBITION, TRIGGERS CELLULAR SENESCENCE AND IS ASSOCIATED WITH PRIMATES AGEING
F Rossiello
Università degli Studi di Milano, 2014
2014
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