David Steger
David Steger
Director of Discovery Research, Gene Therapy Program, University of Pennsylvania
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PPARγ and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale
MI Lefterova, Y Zhang, DJ Steger, M Schupp, J Schug, A Cristancho, ...
Genes & development 22 (21), 2941-2952, 2008
Transcriptional activators direct histone acetyltransferase complexes to nucleosomes
RT Utley, K Ikeda, PA Grant, J Côté, DJ Steger, A Eberharter, S John, ...
Nature 394 (6692), 498-502, 1998
A subset of TAFIIs are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation
PA Grant, D Schieltz, MG Pray-Grant, DJ Steger, JC Reese, JR Yates III, ...
Cell 94 (1), 45-53, 1998
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells
DJ Steger, MI Lefterova, L Ying, AJ Stonestrom, M Schupp, D Zhuo, ...
Molecular and cellular biology 28 (8), 2825-2839, 2008
Regulation of chromatin remodeling by inositol polyphosphates
DJ Steger, ES Haswell, AL Miller, SR Wente, EK O'Shea
Science 299 (5603), 114-116, 2003
Activation domain–mediated targeting of the SWI/SNF complex to promoters stimulates transcription from nucleosome arrays
KE Neely, AH Hassan, AE Wallberg, DJ Steger, BR Cairns, APH Wright, ...
Molecular cell 4 (4), 649-655, 1999
Chromatin decouples promoter threshold from dynamic range
FH Lam, DJ Steger, EK O’Shea
Nature 453 (7192), 246-250, 2008
Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock
Y Zhang, B Fang, MJ Emmett, M Damle, Z Sun, D Feng, SM Armour, ...
Science 348 (6242), 1488-1492, 2015
Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation
SE Mullican, CA Gaddis, T Alenghat, MG Nair, PR Giacomin, LJ Everett, ...
Genes & development 25 (23), 2480-2488, 2011
Propagation of adipogenic signals through an epigenomic transition state
DJ Steger, GR Grant, M Schupp, T Tomaru, MI Lefterova, J Schug, ...
Genes & development 24 (10), 1035-1044, 2010
Cell-specific determinants of peroxisome proliferator-activated receptor γ function in adipocytes and macrophages
MI Lefterova, DJ Steger, D Zhuo, M Qatanani, SE Mullican, G Tuteja, ...
Molecular and cellular biology 30 (9), 2078-2089, 2010
The chromo domain protein chd1p from budding yeast is an ATP-dependent chromatin-modifying factor
HG Tran, DJ Steger, VR Iyer, AD Johnson
The EMBO journal 19 (10), 2323-2331, 2000
GATA-binding proteins regulate the human gonadotropin alpha-subunit gene in the placenta and pituitary gland
DJ Steger, JH Hecht, PL Mellon
Molecular and cellular biology 14 (8), 5592-5602, 1994
Activation domain-specific and general transcription stimulation by native histone acetyltransferase complexes
K Ikeda, DJ Steger, A Eberharter, JL Workman
Molecular and cellular biology 19 (1), 855-863, 1999
Purified histone acetyltransferase complexes stimulate HIV-1 transcription from preassembled nucleosomal arrays
DJ Steger, A Eberharter, S John, PA Grant, JL Workman
Proceedings of the National Academy of Sciences 95 (22), 12924-12929, 1998
Distribution of acetylated histones resulting from Gal4-VP16 recruitment of SAGA and NuA4 complexes
M Vignali, DJ Steger, KE Neely, JL Workman
The EMBO journal 19 (11), 2629-2640, 2000
Identification and characterization of a selective peroxisome proliferator-activated receptor β/δ (NR1C2) antagonist
BG Shearer, DJ Steger, JM Way, TB Stanley, DC Lobe, DA Grillot, ...
Molecular endocrinology 22 (2), 523-529, 2008
Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo
HW Lim, NH Uhlenhaut, A Rauch, J Weiner, S Hübner, N Hübner, KJ Won, ...
Genome research 25 (6), 836-844, 2015
Rev-erbα dynamically modulates chromatin looping to control circadian gene transcription
YH Kim, SA Marhon, Y Zhang, DJ Steger, KJ Won, MA Lazar
Science 359 (6381), 1274-1277, 2018
Remodeling chromatin structures for transcription: what happens to the histones?
DJ Steger, JL Workman
Bioessays 18 (11), 875-884, 1996
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