| Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth D Drygin, A Lin, J Bliesath, CB Ho, SE O'Brien, C Proffitt, M Omori, ... Cancer research 71 (4), 1418-1430, 2011 | 613 | 2011 |
| Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53 MJ Bywater, G Poortinga, E Sanij, N Hein, A Peck, C Cullinane, M Wall, ... Cancer cell 22 (1), 51-65, 2012 | 566 | 2012 |
| The nucleolus: an emerging target for cancer therapy N Hein, KM Hannan, AJ George, E Sanij, RD Hannan Trends in molecular medicine 19 (11), 643-654, 2013 | 267 | 2013 |
| UBF levels determine the number of active ribosomal RNA genes in mammals E Sanij, G Poortinga, K Sharkey, S Hung, TP Holloway, J Quin, E Robb, ... The Journal of cell biology 183 (7), 1259-1274, 2008 | 243 | 2008 |
| Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma O Kondrashova, M Topp, K Nesic, E Lieschke, GY Ho, MI Harrell, ... Nature communications 9 (1), 3970, 2018 | 225 | 2018 |
| Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy J Kang, N Brajanovski, KT Chan, J Xuan, RB Pearson, E Sanij Signal transduction and targeted therapy 6 (1), 323, 2021 | 170 | 2021 |
| First-in-human RNA polymerase I transcription inhibitor CX-5461 in patients with advanced hematologic cancers: results of a phase I dose-escalation study A Khot, N Brajanovski, DP Cameron, N Hein, KH Maclachlan, E Sanij, ... Cancer discovery 9 (8), 1036-1049, 2019 | 162 | 2019 |
| c-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol I availability during granulocyte differentiation G Poortinga, M Wall, E Sanij, K Siwicki, J Ellul, D Brown, TP Holloway, ... Nucleic acids research 39 (8), 3267-3281, 2011 | 147 | 2011 |
| Dysregulation of RNA polymerase I transcription during disease KM Hannan, E Sanij, LI Rothblum, RD Hannan, RB Pearson Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1829 (3-4 …, 2013 | 146 | 2013 |
| The role of UBF in regulating the structure and dynamics of transcriptionally active rDNA chromatin E Sanij, RD Hannan Epigenetics 4 (6), 374-382, 2009 | 137 | 2009 |
| Epstein-Barr virus LMP1 blocks p16INK4a–RB pathway by promoting nuclear export of E2F4/5 N Ohtani, P Brennan, S Gaubatz, E Sanij, P Hertzog, E Wolvetang, ... The Journal of cell biology 162 (2), 173-183, 2003 | 130 | 2003 |
| Combination therapy targeting ribosome biogenesis and mRNA translation synergistically extends survival in MYC-driven lymphoma JR Devlin, KM Hannan, N Hein, C Cullinane, E Kusnadi, PY Ng, ... Cancer discovery 6 (1), 59-70, 2016 | 123 | 2016 |
| ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway EJ Wolvetang, TJ Wilson, E Sanij, J Busciglio, T Hatzistavrou, A Seth, ... Human molecular genetics 12 (3), 247-255, 2003 | 116 | 2003 |
| CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer E Sanij, KM Hannan, J Xuan, S Yan, JE Ahern, AS Trigos, N Brajanovski, ... Nature communications 11 (1), 2641, 2020 | 112 | 2020 |
| Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling J Quin, KT Chan, JR Devlin, DP Cameron, J Diesch, C Cullinane, J Ahern, ... Oncotarget 7 (31), 49800, 2016 | 104 | 2016 |
| Conditional inactivation of Upstream Binding Factor reveals its epigenetic functions and the existence of a somatic nucleolar precursor body N Hamdane, VY Stefanovsky, MG Tremblay, A Nemeth, E Paquet, ... PLoS genetics 10 (8), e1004505, 2014 | 92 | 2014 |
| Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma S AbuHammad, C Cullinane, C Martin, Z Bacolas, T Ward, H Chen, ... Proceedings of the National Academy of Sciences 116 (36), 17990-18000, 2019 | 88 | 2019 |
| Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers M Udugama, E Sanij, HPJ Voon, J Son, L Hii, JD Henson, FL Chan, ... Proceedings of the National Academy of Sciences 115 (18), 4737-4742, 2018 | 87 | 2018 |
| Widespread FRA1-dependent control of mesenchymal transdifferentiation programs in colorectal cancer cells J Diesch, E Sanij, O Gilan, C Love, H Tran, NI Fleming, J Ellul, M Amalia, ... PloS one 9 (3), e88950, 2014 | 85 | 2014 |
| Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population N Hein, DP Cameron, KM Hannan, NYN Nguyen, CY Fong, J Sornkom, ... Blood, The Journal of the American Society of Hematology 129 (21), 2882-2895, 2017 | 84 | 2017 |
