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Daniel D Seaton
Daniel D Seaton
Scientific director, Computational biology, GSK
Geverifieerd e-mailadres voor gsk.com
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Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression
ASE Cuomo, DD Seaton, DJ McCarthy, I Martinez, MJ Bonder, ...
Nature communications 11 (1), 810, 2020
2282020
Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation
J Jerber, DD Seaton, ASE Cuomo, N Kumasaka, J Haldane, J Steer, ...
Nature genetics 53 (3), 304-312, 2021
1572021
Photoreceptor effects on plant biomass, resource allocation, and metabolic state
D Yang, DD Seaton, J Krahmer, KJ Halliday
Proceedings of the National Academy of Sciences 113 (27), 7667-7672, 2016
1242016
Linked circadian outputs control elongation growth and flowering in response to photoperiod and temperature
DD Seaton, RW Smith, YH Song, DR MacGregor, K Stewart, G Steel, ...
Molecular systems biology 11 (1), 776, 2015
1082015
Photoperiodic control of the Arabidopsis proteome reveals a translational coincidence mechanism
DD Seaton, A Graf, K Baerenfaller, M Stitt, AJ Millar, W Gruissem
Molecular systems biology 14 (3), e7962, 2018
712018
Photoperiod‐dependent changes in the phase of core clock transcripts and global transcriptional outputs at dawn and dusk in Arabidopsis
A Flis, R Sulpice, DD Seaton, AA Ivakov, M Liput, C Abel, AJ Millar, M Stitt
Plant, cell & environment 39 (9), 1955-1981, 2016
632016
Population-scale proteome variation in human induced pluripotent stem cells
BA Mirauta, DD Seaton, D Bensaddek, A Brenes, MJ Bonder, H Kilpinen, ...
Elife 9, e57390, 2020
552020
Identification of rare and common regulatory variants in pluripotent cells using population-scale transcriptomics
MJ Bonder, C Smail, MJ Gloudemans, L Frésard, D Jakubosky, ...
Nature genetics 53 (3), 313-321, 2021
442021
Defining the robust behaviour of the plant clock gene circuit with absolute RNA timeseries and open infrastructure
A Flis, AP Fernández, T Zielinski, V Mengin, R Sulpice, K Stratford, ...
Open Biology 5 (10), 150042, 2015
432015
Dawn and photoperiod sensing by phytochrome A
DD Seaton, G Toledo-Ortiz, A Ganpudi, A Kubota, T Imaizumi, KJ Halliday
Proceedings of the National Academy of Sciences 115 (41), 10523-10528, 2018
402018
Mathematical models light up plant signaling
YH Chew, RW Smith, HJ Jones, DD Seaton, R Grima, KJ Halliday
The Plant Cell 26 (1), 5-20, 2014
392014
Regulatory principles and experimental approaches to the circadian control of starch turnover
DD Seaton, O Ebenhöh, AJ Millar, A Pokhilko
Journal of the Royal Society Interface 11 (91), 20130979, 2014
332014
Erosion of human X chromosome inactivation causes major remodeling of the iPSC proteome
AJ Brenes, H Yoshikawa, D Bensaddek, B Mirauta, D Seaton, ...
Cell reports 35 (4), 2021
272021
Multi-scale modelling to synergise plant systems biology and crop science
YH Chew, DD Seaton, AJ Millar
Field Crops Research 202, 77-83, 2017
222017
An explanatory model of temperature influence on flowering through whole-plant accumulation of FLOWERING LOCUS T in Arabidopsis thaliana
HA Kinmonth-Schultz, MJS MacEwen, DD Seaton, AJ Millar, T Imaizumi, ...
in silico Plants 1 (1), diz006, 2019
202019
Linking circadian time to growth rate quantitatively via carbon metabolism
YH Chew, D Seaton, V Mengin, A Flis, ST Mugford, AM Smith, M Stitt, ...
162017
The coupling of pathways and processes through shared components
DD Seaton, J Krishnan
BMC systems biology 5, 1-27, 2011
162011
Model-based analysis of cell cycle responses to dynamically changing environments
DD Seaton, J Krishnan
PLoS computational biology 12 (1), e1004604, 2016
152016
Systematic assessment of regulatory effects of human disease variants in pluripotent cells
MJ Bonder, C Smail, MJ Gloudemans, L Frésard, D Jakubosky, ...
bioRxiv, 784967, 2019
142019
Modular systems approach to understanding the interaction of adaptive and monostable and bistable threshold processes
D Seaton, J Krishnan
IET systems biology 5 (2), 81-94, 2011
142011
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Artikelen 1–20