Jean-Pierre Issa
Jean-Pierre Issa
Coriell Institute for Medical Research
Verified email at - Homepage
Cited by
Cited by
CpG island methylator phenotype in colorectal cancer
M Toyota, N Ahuja, M Ohe-Toyota, JG Herman, SB Baylin, JPJ Issa
Proceedings of the National Academy of Sciences 96 (15), 8681-8686, 1999
Alterations in DNA methylation: a fundamental aspect of neoplasia
SB Baylln, JG Herman, JR Graff, PM Vertino, JP Issa
Advances in cancer research 72, 141-196, 1997
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
JG Herman, A Umar, K Polyak, JR Graff, N Ahuja, JPJ Issa, S Markowitz, ...
Proceedings of the National Academy of Sciences 95 (12), 6870-6875, 1998
Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
JG Herman, A Merlo, LI Mao, RG Lapidus, JPJ Issa, NE Davidson, ...
Cancer research 55 (20), 4525-4530, 1995
Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study
H Kantarjian, JPJ Issa, CS Rosenfeld, JM Bennett, M Albitar, J DiPersio, ...
Cancer: Interdisciplinary International Journal of the American Cancer …, 2006
Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon
JPJ Issa, YL Ottaviano, P Celano, SR Hamilton, NE Davidson, SB Baylin
Nature genetics 7 (4), 536-540, 1994
CpG island methylator phenotype in cancer
JP Issa
Nature Reviews Cancer 4 (12), 988-993, 2004
A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements
AS Yang, MRH Estécio, K Doshi, Y Kondo, EH Tajara, JPJ Issa
Nucleic acids research 32 (3), e38-e38, 2004
Dnmt3a is essential for hematopoietic stem cell differentiation
GA Challen, D Sun, M Jeong, M Luo, J Jelinek, JS Berg, C Bock, ...
Nature genetics 44 (1), 23-31, 2012
Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies
JPJ Issa, G Garcia-Manero, FJ Giles, R Mannari, D Thomas, S Faderl, ...
Blood 103 (5), 1635-1640, 2004
Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia
H Kantarjian, Y Oki, G Garcia-Manero, X Huang, S O'Brien, J Cortes, ...
Blood 109 (1), 52-57, 2007
Targeting the cancer epigenome for therapy
PA Jones, JPJ Issa, S Baylin
Nature Reviews Genetics 17 (10), 630-641, 2016
Aging and DNA methylation in colorectal mucosa and cancer
N Ahuja, Q Li, AL Mohan, SB Baylin, JPJ Issa
Cancer research 58 (23), 5489-5494, 1998
Accelerated age-related CpG island methylation in ulcerative colitis
JPJ Issa, N Ahuja, M Toyota, MP Bronner, TA Brentnall
Cancer research 61 (9), 3573-3577, 2001
Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
Y Kondo, L Shen, AS Cheng, S Ahmed, Y Boumber, C Charo, T Yamochi, ...
Nature genetics 40 (6), 741-750, 2008
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis
M Esteller, M Toyota, M Sanchez-Cespedes, G Capella, MA Peinado, ...
Cancer research 60 (9), 2368-2371, 2000
Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer
L Shen, M Toyota, Y Kondo, E Lin, L Zhang, Y Guo, NS Hernandez, ...
Proceedings of the National Academy of Sciences 104 (47), 18654-18659, 2007
Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells
YL Ottaviano, JP Issa, FF Parl, HS Smith, SB Baylin, NE Davidson
Cancer research 54 (10), 2552-2555, 1994
Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype
M Toyota, N Ahuja, H Suzuki, F Itoh, M Ohe-Toyota, K Imai, SB Baylin, ...
Cancer research 59 (21), 5438-5442, 1999
Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification
M Toyota, C Ho, N Ahuja, KW Jair, Q Li, M Ohe-Toyota, SB Baylin, ...
Cancer research 59 (10), 2307-2312, 1999
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