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Graham Frank Smith
Graham Frank Smith
AstraZeneca, Merck, Pfizer, Rhone-Poulenc Rorer, Ohio State, Nottingham University
Verified email at astrazeneca.com
Title
Cited by
Cited by
Year
Designing drugs to avoid toxicity
GF Smith
Progress in medicinal chemistry 50, 1-47, 2011
1292011
Total synthesis of spinosyn A. 1. Enantioselective construction of a key tricyclic Intermediate by a multiple configurational inversion scheme
LA Paquette, Z Gao, Z Ni, GF Smith
Journal of the American Chemical Society 120 (11), 2543-2552, 1998
1081998
Discovery of selective RNA-binding small molecules by affinity-selection mass spectrometry
NF Rizvi, JA Howe, A Nahvi, DJ Klein, TO Fischmann, HY Kim, MA McCoy, ...
ACS chemical biology 13 (3), 820-831, 2018
882018
RNA as a small molecule druggable target
NF Rizvi, GF Smith
Bioorganic & Medicinal Chemistry Letters 27 (23), 5083-5088, 2017
722017
Targeting RNA with small molecules: identification of selective, RNA-binding small molecules occupying drug-like chemical space
NF Rizvi, JP Santa Maria Jr, A Nahvi, J Klappenbach, DJ Klein, PJ Curran, ...
SLAS DISCOVERY: Advancing the Science of Drug Discovery 25 (4), 384-396, 2020
682020
Targeting Xist with compounds that disrupt RNA structure and X inactivation
R Aguilar, KB Spencer, B Kesner, NF Rizvi, MD Badmalia, T Mrozowich, ...
Nature 604 (7904), 160-166, 2022
562022
The Landscape of Potential Small and Drug Substance Related Nitrosamines in Pharmaceuticals
J Schlingemann, MJ Burns, DJ Ponting, CM Avila, NE Romero, ...
Journal of Pharmaceutical Sciences, 2022
462022
(4R)-(+)-TERT-BUTYLDIMETHYLSILOXY-2-CYCLOPENTEN-1-ONE:(2-CYCLOPENTEN-1-ONE, 4-1, 1-DIMETHYLETHYL) DIMETHYLSILYLOXY-,(R)-
LA Paquette, MJ Earle, GF Smith
Organic syntheses 73, 36-43, 1996
451996
Medicinal chemistry by the numbers: the physicochemistry, thermodynamics and kinetics of modern drug design
GF Smith
Progress in medicinal chemistry 48, 1-29, 2009
442009
Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4
J Lim, MD Altman, J Baker, JD Brubaker, H Chen, Y Chen, T Fischmann, ...
ACS medicinal chemistry letters 6 (6), 683-688, 2015
402015
Synthetic studies on spinosyn A. Convenient enantioselective construction of a suitably functionalized trans, anti, cis-decahydro-as-indacene intermediate via [3.3] sigmatropy …
LA Paquette, Z Gao, Z Ni, GF Smith
Tetrahedron letters 38 (8), 1271-1274, 1997
401997
Identification of N-(1H-pyrazol-4-yl) carboxamide inhibitors of interleukin-1 receptor associated kinase 4: Bicyclic core modifications
J Lim, MD Altman, J Baker, JD Brubaker, H Chen, Y Chen, MA Kleinschek, ...
Bioorganic & Medicinal Chemistry Letters 25 (22), 5384-5388, 2015
302015
Prediction of in vivo pharmacokinetic parameters and time–exposure curves in rats using machine learning from the chemical structure
O Obrezanova, A Martinsson, T Whitehead, S Mahmoud, A Bender, ...
Molecular pharmaceutics 19 (5), 1488-1504, 2022
272022
The application of non-combinatorial chemistry to lead discovery
J Everett, M Gardner, F Pullen, GF Smith, M Snarey, N Terrett
Drug discovery today 6 (15), 779-785, 2001
272001
Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation
GF Smith, MD Altman, B Andresen, J Baker, JD Brubaker, H Chen, ...
Bioorganic & medicinal chemistry letters 27 (12), 2721-2726, 2017
252017
Inhibitors of IRAK4 activity
MD Altman, JD Brubaker, ML Childers, A Donofrio, T Fischmann, ...
US Patent 9,926,330, 2018
232018
Structure–activity relationships of novel non-competitive mGluR1 antagonists: A potential treatment for chronic pain
DR Owen, PG Dodd, S Gayton, BS Greener, GW Harbottle, SJ Mantell, ...
Bioorganic & medicinal chemistry letters 17 (2), 486-490, 2007
232007
Identification of G-quadruplex-binding inhibitors of Myc expression through affinity selection–mass spectrometry
DA Flusberg, NF Rizvi, V Kutilek, C Andrews, P Saradjian, C Chamberlin, ...
SLAS DISCOVERY: Advancing the Science of Drug Discovery 24 (2), 142-157, 2019
202019
Synthesis of cyclic peptidomimetics via a pd-catalyzed macroamination reaction
BA Hopkins, GF Smith, N Sciammetta
Organic letters 18 (16), 4072-4075, 2016
162016
Bipyridylaminopyridines as Syk inhibitors
D Deschenes, MD Altman, JM Ellis, C Fischer, AM Haidle, SD Kattar, ...
US Patent 9,145,391, 2015
162015
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