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Brian Blagg
Brian Blagg
Professor of Chemistry and Biochemistry
Verified email at nd.edu
Title
Cited by
Cited by
Year
Novobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket
A Donnelly, BSJ Blagg
Current medicinal chemistry 15 (26), 2702-2717, 2008
3762008
Novobiocin: redesigning a DNA gyrase inhibitor for selective inhibition of hsp90
JA Burlison, L Neckers, AB Smith, A Maxwell, BSJ Blagg
Journal of the American Chemical Society 128 (48), 15529-15536, 2006
2812006
Hsp90 inhibitors: small molecules that transform the Hsp90 protein folding machinery into a catalyst for protein degradation
BSJ Blagg, TD Kerr
Medicinal research reviews 26 (3), 310-338, 2006
2332006
Hsp90 inhibitors identified from a library of novobiocin analogues
XM Yu, G Shen, L Neckers, H Blake, J Holzbeierlein, B Cronk, BSJ Blagg
Journal of the American Chemical Society 127 (37), 12778-12779, 2005
2222005
A first-in-class polymerase theta inhibitor selectively targets homologous-recombination-deficient tumors
J Zhou, C Gelot, C Pantelidou, A Li, H Yücel, RE Davis, A Färkkilä, ...
Nature cancer 2 (6), 598-610, 2021
1992021
Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function
M Mollapour, S Tsutsumi, AC Donnelly, K Beebe, MJ Tokita, MJ Lee, ...
Molecular cell 37 (3), 333-343, 2010
1942010
Gedunin, a novel Hsp90 inhibitor: semisynthesis of derivatives and preliminary structure− activity relationships
GEL Brandt, MD Schmidt, TE Prisinzano, BSJ Blagg
Journal of medicinal chemistry 51 (20), 6495-6502, 2008
1902008
The design, synthesis, and evaluation of coumarin ring derivatives of the novobiocin scaffold that exhibit antiproliferative activity
AC Donnelly, JR Mays, JA Burlison, JT Nelson, G Vielhauer, ...
The Journal of organic chemistry 73 (22), 8901-8920, 2008
1852008
Engineering an antibiotic to fight cancer: optimization of the novobiocin scaffold to produce anti-proliferative agents
H Zhao, AC Donnelly, BR Kusuma, GEL Brandt, D Brown, RA Rajewski, ...
Journal of medicinal chemistry 54 (11), 3839-3853, 2011
1842011
E. coli MEP Synthase:  Steady-State Kinetic Analysis and Substrate Binding
AT Koppisch, DT Fox, BSJ Blagg, CD Poulter
Biochemistry 41 (1), 236-243, 2002
1722002
Development of novobiocin analogues that manifest anti-proliferative activity against several cancer cell lines
JA Burlison, C Avila, G Vielhauer, DJ Lubbers, J Holzbeierlein, BSJ Blagg
The Journal of organic chemistry 73 (6), 2130-2137, 2008
1612008
Gedunin Inactivates the Co-chaperone p23 Protein Causing Cancer Cell Death by Apoptosis*♦
CA Patwardhan, A Fauq, LB Peterson, C Miller, BSJ Blagg, A Chadli
Journal of Biological Chemistry 288 (10), 7313-7325, 2013
1592013
A non-toxic Hsp90 inhibitor protects neurons from Aβ-induced toxicity
S Ansar, JA Burlison, MK Hadden, XM Yu, KE Desino, J Bean, L Neckers, ...
Bioorganic & medicinal chemistry letters 17 (7), 1984-1990, 2007
1532007
Anticancer inhibitors of Hsp90 function: beyond the usual suspects
G Garg, A Khandelwal, BSJ Blagg
Advances in cancer research 129, 51-88, 2016
1522016
Gambogic acid, a natural product inhibitor of Hsp90
J Davenport, JR Manjarrez, L Peterson, B Krumm, BSJ Blagg, RL Matts
Journal of natural products 74 (5), 1085-1092, 2011
1432011
Intramolecular Diels− Alder and tandem intramolecular Diels− Alder/1, 3-dipolar cycloaddition reactions of 1, 3, 4-oxadiazoles
GD Wilkie, GI Elliott, BSJ Blagg, SE Wolkenberg, DR Soenen, MM Miller, ...
Journal of the American Chemical Society 124 (38), 11292-11294, 2002
1352002
Old and new approaches to target the Hsp90 chaperone
J Sanchez, TR Carter, MS Cohen, BSJ Blagg
Current cancer drug targets 20 (4), 253-270, 2020
1302020
Intramolecular Diels− Alder/1, 3-dipolar cycloaddition cascade of 1, 3, 4-oxadiazoles
GI Elliott, JR Fuchs, BSJ Blagg, H Ishikawa, H Tao, ZQ Yuan, DL Boger
Journal of the American Chemical Society 128 (32), 10589-10595, 2006
1292006
Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells
JD Eskew, T Sadikot, P Morales, A Duren, I Dunwiddie, M Swink, X Zhang, ...
BMC cancer 11, 1-16, 2011
1212011
Elucidation of the Hsp90 C-terminal inhibitor binding site
RL Matts, A Dixit, LB Peterson, L Sun, S Voruganti, P Kalyanaraman, ...
ACS chemical biology 6 (8), 800-807, 2011
1182011
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