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William Zuercher
William Zuercher
Senior Principal Scientist, Pharma Research and Early Development, F. Hoffmann-La Roche
Geverifieerd e-mailadres voor roche.com
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The promise and peril of chemical probes
CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ...
Nature chemical biology 11 (8), 536-541, 2015
8282015
Comprehensive characterization of the published kinase inhibitor set
JM Elkins, V Fedele, M Szklarz, KR Abdul Azeez, E Salah, J Mikolajczyk, ...
Nature biotechnology 34 (1), 95-103, 2016
3312016
Tandem ring opening− ring closing metathesis of cyclic olefins
WJ Zuercher, M Hashimoto, RH Grubbs
Journal of the American Chemical Society 118 (28), 6634-6640, 1996
3131996
Catalytic Ring Closing Metathesis of Dienynes: Construction of Fused Bicyclic [n. m. 0] Rings
SH Kim, WJ Zuercher, NB Bowden, RH Grubbs
The Journal of Organic Chemistry 61 (3), 1073-1081, 1996
2371996
Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation
RD Michalek, VA Gerriets, AG Nichols, M Inoue, D Kazmin, CY Chang, ...
Proceedings of the National Academy of Sciences 108 (45), 18348-18353, 2011
2332011
A public-private partnership to unlock the untargeted kinome
S Knapp, P Arruda, J Blagg, S Burley, DH Drewry, A Edwards, D Fabbro, ...
Nature chemical biology 9 (1), 3-6, 2013
1722013
An efficient, general asymmetric synthesis of carbocyclic nucleosides: application of an asymmetric aldol/ring-closing metathesis strategy
MT Crimmins, BW King, WJ Zuercher, AL Choy
The Journal of Organic Chemistry 65 (25), 8499-8509, 2000
1722000
The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer
C Chang, D Kazmin, JS Jasper, R Kunder, WJ Zuercher, DP McDonnell
Cancer cell 20 (4), 500-510, 2011
1632011
Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation
M Pariollaud, JE Gibbs, TW Hopwood, S Brown, N Begley, R Vonslow, ...
The Journal of clinical investigation 128 (6), 2281-2296, 2018
1512018
Ruthenium-catalyzed polycyclization reactions
WJ Zuercher, M Scholl, RH Grubbs
The Journal of Organic Chemistry 63 (13), 4291-4298, 1998
1511998
X-ray crystal structures of the estrogen-related receptor-γ ligand binding domain in three functional states reveal the molecular basis of small molecule regulation
L Wang, WJ Zuercher, TG Consler, MH Lambert, AB Miller, ...
Journal of Biological Chemistry 281 (49), 37773-37781, 2006
1472006
Progress towards a public chemogenomic set for protein kinases and a call for contributions
DH Drewry, CI Wells, DM Andrews, R Angell, H Al-Ali, AD Axtman, ...
PloS one 12 (8), e0181585, 2017
1462017
GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα
D Grant, L Yin, JL Collins, DJ Parks, LA Orband-Miller, GB Wisely, S Joshi, ...
ACS chemical biology 5 (10), 925-932, 2010
1442010
Crystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonism
Y Xue, E Chao, WJ Zuercher, TM Willson, JL Collins, MR Redinbo
Bioorganic & medicinal chemistry 15 (5), 2156-2166, 2007
1402007
Identification and structure− activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRβ and ERRγ
WJ Zuercher, S Gaillard, LA Orband-Miller, EYH Chao, BG Shearer, ...
Journal of medicinal chemistry 48 (9), 3107-3109, 2005
1242005
Seeding collaborations to advance kinase science with the GSK Published Kinase Inhibitor Set (PKIS)
D H Drewry, T M Willson, W J Zuercher
Current topics in medicinal chemistry 14 (3), 340-342, 2014
1232014
Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRγ
EYH Chao, JL Collins, S Gaillard, AB Miller, L Wang, LA Orband-Miller, ...
Bioorganic & medicinal chemistry letters 16 (4), 821-824, 2006
1052006
Discovery of tertiary sulfonamides as potent liver X receptor antagonists
WJ Zuercher, RG Buckholz, N Campobasso, JL Collins, CM Galardi, ...
Journal of medicinal chemistry 53 (8), 3412-3416, 2010
1002010
Donated chemical probes for open science
S Müller, S Ackloo, CH Arrowsmith, M Bauser, JL Baryza, J Blagg, ...
Elife 7, e34311, 2018
922018
Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2)
RJ Whitby, J Stec, RD Blind, S Dixon, LM Leesnitzer, LA Orband-Miller, ...
Journal of medicinal chemistry 54 (7), 2266-2281, 2011
922011
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