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Joseph W. Lewcock
Joseph W. Lewcock
CSO and Head of Discovery, Denali Therapeutics
Geverifieerd e-mailadres voor dnli.com
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TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge
AA Nugent, K Lin, B Van Lengerich, S Lianoglou, L Przybyla, SS Davis, ...
Neuron 105 (5), 837-854. e9, 2020
4262020
A feedback mechanism regulates monoallelic odorant receptor expression
JW Lewcock, RR Reed
Proceedings of the National Academy of Sciences 101 (4), 1069-1074, 2004
3032004
DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury
TA Watkins, B Wang, S Huntwork-Rodriguez, J Yang, Z Jiang, ...
Proceedings of the National Academy of Sciences 110 (10), 4039-4044, 2013
3002013
The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics
JW Lewcock, N Genoud, K Lettieri, SL Pfaff
Neuron 56 (4), 604-620, 2007
2242007
DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity
A Sengupta Ghosh, B Wang, CD Pozniak, M Chen, RJ Watts, JW Lewcock
Journal of Cell Biology 194 (5), 751-764, 2011
2102011
Enhancing protective microglial activities with a dual function TREM 2 antibody to the stalk region
K Schlepckow, KM Monroe, G Kleinberger, L Cantuti‐Castelvetri, ...
EMBO molecular medicine 12 (4), e11227, 2020
1862020
Small-molecule modulation of TDP-43 recruitment to stress granules prevents persistent TDP-43 accumulation in ALS/FTD
MY Fang, S Markmiller, AQ Vu, A Javaherian, WE Dowdle, P Jolivet, ...
Neuron 103 (5), 802-819. e11, 2019
1862019
Cholinergic input is required during embryonic development to mediate proper assembly of spinal locomotor circuits
CP Myers, JW Lewcock, MG Hanson, S Gosgnach, JB Aimone, FH Gage, ...
Neuron 46 (1), 37-49, 2005
1702005
Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia
BJ Andreone, L Przybyla, C Llapashtica, A Rana, SS Davis, ...
Nature Neuroscience 23 (8), 927-938, 2020
1602020
Emerging microglia biology defines novel therapeutic approaches for Alzheimer’s disease
JW Lewcock, K Schlepckow, G Di Paolo, S Tahirovic, KM Monroe, ...
Neuron 108 (5), 801-821, 2020
1582020
Genetic disruptions of O/E2 and O/E3 genes reveal involvement in olfactory receptor neuron projection
SS Wang, JW Lewcock, P Feinstein, P Mombaerts, RR Reed
Oxford University Press for The Company of Biologists Limited 131 (6), 1377-1388, 2004
1572004
JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis
S Huntwork-Rodriguez, B Wang, T Watkins, AS Ghosh, CD Pozniak, ...
Journal of Cell Biology 202 (5), 747-763, 2013
1502013
Presenilin-dependent receptor processing is required for axon guidance
G Bai, O Chivatakarn, D Bonanomi, K Lettieri, L Franco, C Xia, E Stein, ...
Cell 144 (1), 106-118, 2011
1352011
Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease
CE Le Pichon, WJ Meilandt, S Dominguez, H Solanoy, H Lin, H Ngu, ...
Science translational medicine 9 (403), eaag0394, 2017
1322017
FGF as a target-derived chemoattractant for developing motor axons genetically programmed by the LIM code
R Shirasaki, JW Lewcock, K Lettieri, SL Pfaff
Neuron 50 (6), 841-853, 2006
1312006
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic
T Logan, MJ Simon, A Rana, GM Cherf, A Srivastava, SS Davis, RLY Low, ...
Cell 184 (18), 4651-4668. e25, 2021
1132021
Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration
CD Pozniak, A Sengupta Ghosh, A Gogineni, JE Hanson, SH Lee, ...
Journal of Experimental Medicine 210 (12), 2553-2567, 2013
832013
Leveraging preclinical models for the development of Alzheimer disease therapeutics
K Scearce-Levie, PE Sanchez, JW Lewcock
Nature Reviews Drug Discovery 19 (7), 447-462, 2020
822020
The Ste20 family kinases MAP4K4, MINK1, and TNIK converge to regulate stress-induced JNK signaling in neurons
M Larhammar, S Huntwork-Rodriguez, Y Rudhard, A Sengupta-Ghosh, ...
Journal of Neuroscience 37 (46), 11074-11084, 2017
822017
Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models
S Patel, F Cohen, BJ Dean, K De La Torre, G Deshmukh, AA Estrada, ...
Journal of medicinal chemistry 58 (1), 401-418, 2015
812015
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Artikelen 1–20