| Expanding our understanding of the role polyprotein conformation plays in the coronavirus life cycle S Gildenhuys Biochemical Journal 477 (8), 1479-1482, 2020 | 33 | 2020 |
| Benzofuran-selenadiazole hybrids as novel α-glucosidase and cyclooxygenase-2 inhibitors with antioxidant and cytotoxic properties TO Olomola, MJ Mphahlele, S Gildenhuys Bioorganic chemistry 100, 103945, 2020 | 27 | 2020 |
| Synthesis, α-glucosidase inhibition and antioxidant activity of the 7-carbo–substituted 5-bromo-3-methylindazoles MJ Mphahlele, NM Magwaza, S Gildenhuys, IB Setshedi Bioorganic chemistry 97, 103702, 2020 | 24 | 2020 |
| Arginine 15 stabilizes an SNAr reaction transition state and the binding of anionic ligands at the active site of human glutathione transferase A1-1 S Gildenhuys, M Dobreva, N Kinsley, Y Sayed, J Burke, S Pelly, ... Biophysical chemistry 146 (2-3), 118-125, 2010 | 24 | 2010 |
| Stability of the domain interface contributes towards the catalytic function at the H-site of class alpha glutathione transferase A1-1 D Balchin, S Fanucchi, I Achilonu, RJ Adamson, J Burke, M Fernandes, ... Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1804 (12), 2228-2233, 2010 | 23 | 2010 |
| Synthesis, In Vitro Evaluation and Molecular Docking of the 5-Acetyl-2-aryl-6-hydroxybenzo[b]furans against Multiple Targets Linked to Type 2 Diabetes MJ Mphahlele, YS Choong, MM Maluleka, S Gildenhuys Biomolecules 10 (3), 418, 2020 | 21 | 2020 |
| Synthesis of furocoumarin–stilbene hybrids as potential multifunctional drugs against multiple biochemical targets associated with Alzheimer’s disease EN Agbo, S Gildenhuys, YS Choong, MJ Mphahlele, GK More Bioorganic chemistry 101, 103997, 2020 | 20 | 2020 |
| Class Pi glutathione transferase unfolds via a dimeric and not monomeric intermediate: functional implications for an unstable monomer S Gildenhuys, LA Wallace, JP Burke, D Balchin, Y Sayed, HW Dirr Biochemistry 49 (24), 5074-5081, 2010 | 20 | 2010 |
| Synthesis and evaluation of the 4-substituted 2-hydroxy-5-iodochalcones and their 7-substituted 6-iodoflavonol derivatives for inhibitory effect on cholinesterases and β-secretase MJ Mphahlele, EN Agbo, S Gildenhuys International Journal of Molecular Sciences 19 (12), 4112, 2018 | 17 | 2018 |
| Analysis of conserved, computationally predicted epitope regions for VP5 and VP7 across three orbiviruses BL Russell, N Parbhoo, S Gildenhuys Bioinformatics and biology insights 12, 1177932218755348, 2018 | 14 | 2018 |
| Exploring Biological Activity of 4-Oxo-4H-furo[2,3-h]chromene Derivatives as Potential Multi-Target-Directed Ligands Inhibiting Cholinesterases, β-Secretase … MJ Mphahlele, EN Agbo, S Gildenhuys, IB Setshedi Biomolecules 9 (11), 736, 2019 | 13 | 2019 |
| Functional screening of a soil metagenome for DNA endonucleases by acquired resistance to bacteriophage infection S Mtimka, P Pillay, K Rashamuse, S Gildenhuys, TL Tsekoa Molecular biology reports 47, 353-361, 2020 | 12 | 2020 |
| Synthesis, Cytotoxicity and Molecular Docking Studies of the 9-Substituted 5-Styryltetrazolo[1,5-c]quinazoline Derivatives MJ Mphahlele, S Gildenhuys, N Parbhoo Molecules 22 (11), 1719, 2017 | 11 | 2017 |
| The effects of temperature on streptavidin-biotin binding using affinity isothermal titration calorimetry KL Mpye, S Gildenhuys, S Mosebi AIMS Biophysics 7 (4), 236-247, 2020 | 10 | 2020 |
| In Vitro Evaluation and Docking Studies of 5-oxo-5H-furo[3,2-g]chromene-6-carbaldehyde Derivatives as Potential Anti-Alzheimer’s Agents MJ Mphahlele, S Gildenhuys, EN Agbo International Journal of Molecular Sciences 20 (21), 5451, 2019 | 10 | 2019 |
| The role of a topologically conserved isoleucine in glutathione transferase structure, stability and function I Achilonu, S Gildenhuys, L Fisher, J Burke, S Fanucchi, BT Sewell, ... Acta Crystallographica Section F: Structural Biology and Crystallization …, 2010 | 10 | 2010 |
| Effect of macromolecular crowding on the stability of monomeric glutaredoxin 2 and dimeric glutathione transferase A1-1 DC Kuhnert, S Gildenhuys, HW Dirr South African Journal of Science 104 (1), 76-80, 2008 | 10 | 2008 |
| Sequence analysis and structural implications of rotavirus capsid proteins N Parbhoo, JB Dewar, S Gildenhuys Acta Virol 60 (3), 260-270, 2016 | 8 | 2016 |
| Solubilisation and purification of recombinant bluetongue virus VP7 expressed in a bacterial system BL Russell, S Gildenhuys Protein Expression and Purification 147, 85-93, 2018 | 7 | 2018 |
| A conserved interdomain interaction is a determinant of folding cooperativity in the GST fold N Parbhoo, SH Stoychev, S Fanucchi, I Achilonu, RJ Adamson, ... Biochemistry 50 (32), 7067-7075, 2011 | 6 | 2011 |
Ikechukwu AchilonuSenior Researcher of Molecular and Cell BiologyGeverifieerd e-mailadres voor wits.ac.za
