Jake Shortt
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Drug response in a genetically engineered mouse model of multiple myeloma is predictive of clinical efficacy
M Chesi, GM Matthews, VM Garbitt, SE Palmer, J Shortt, M Lefebure, ...
Blood, The Journal of the American Society of Hematology 120 (2), 376-385, 2012
1632012
BET-bromodomain inhibitors engage the host immune system and regulate expression of the immune checkpoint ligand PD-L1
SJ Hogg, SJ Vervoort, S Deswal, CJ Ott, J Li, LA Cluse, PA Beavis, ...
Cell reports 18 (9), 2162-2174, 2017
1352017
Oncogenes in cell survival and cell death
J Shortt, RW Johnstone
Cold Spring Harbor perspectives in biology 4 (12), a009829, 2012
1152012
An intact immune system is required for the anticancer activities of histone deacetylase inhibitors
AC West, SR Mattarollo, J Shortt, LA Cluse, AJ Christiansen, MJ Smyth, ...
Cancer research 73 (24), 7265-7276, 2013
1042013
CDK9 inhibition by dinaciclib potently suppresses Mcl-1 to induce durable apoptotic responses in aggressive MYC-driven B-cell lymphoma in vivo
GP Gregory, SJ Hogg, LM Kats, E Vidacs, AJ Baker, O Gilan, M Lefebure, ...
Leukemia 29 (6), 1437-1441, 2015
982015
ADAMTS13 antibody depletion by bortezomib in thrombotic thrombocytopenic purpura
MB Jake Shortt, SS Opat
The New England journal of medicine 368 (1), 90, 2013
982013
Differentiation therapy for the treatment of t (8; 21) acute myeloid leukemia using histone deacetylase inhibitors
M Bots, I Verbrugge, BP Martin, JM Salmon, M Ghisi, A Baker, K Stanley, ...
Blood, The Journal of the American Society of Hematology 123 (9), 1341-1352, 2014
952014
Thalidomide-analogue biology: immunological, molecular and epigenetic targets in cancer therapy
J Shortt, AK Hsu, RW Johnstone
Oncogene 32 (36), 4191-4202, 2013
932013
Combination therapy targeting ribosome biogenesis and mRNA translation synergistically extends survival in MYC-driven lymphoma
JR Devlin, KM Hannan, N Hein, C Cullinane, E Kusnadi, PY Ng, ...
Cancer discovery 6 (1), 59-70, 2016
812016
Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas
J Shortt, BP Martin, A Newbold, KM Hannan, JR Devlin, AJ Baker, R Ralli, ...
Blood 121 (15), 2964-2974, 2013
732013
A chemical probe toolbox for dissecting the cancer epigenome
J Shortt, CJ Ott, RW Johnstone, JE Bradner
Nature Reviews Cancer 17 (3), 160, 2017
702017
NKT cell adjuvant-based tumor vaccine for treatment of myc oncogene-driven mouse B-cell lymphoma
SR Mattarollo, AC West, K Steegh, H Duret, C Paget, B Martin, ...
Blood, The Journal of the American Society of Hematology 120 (15), 3019-3029, 2012
692012
The CDK9 inhibitor dinaciclib exerts potent apoptotic and antitumor effects in preclinical models of MLL-rearranged acute myeloid leukemia
A Baker, GP Gregory, I Verbrugge, L Kats, JJ Hilton, E Vidacs, EM Lee, ...
Cancer research 76 (5), 1158-1169, 2016
652016
Adjuvant rituximab causes prolonged hypogammaglobulinaemia following autologous stem cell transplant for non-Hodgkin's lymphoma
J Shortt, A Spencer
Bone marrow transplantation 38 (6), 433-436, 2006
632006
The mTORC1 inhibitor everolimus prevents and treats Eμ-Myc lymphoma by restoring oncogene-induced senescence
M Wall, G Poortinga, KL Stanley, RK Lindemann, M Bots, CJ Chan, ...
Cancer discovery 3 (1), 82-95, 2013
602013
AIDS-related plasmablastic lymphoma of the oral cavity associated with an IGH/MYC translocation–treatment with autologous stem-cell transplantation in a patient with severe …
MA Dawson, AP Schwarer, C McLean, P Oei, LJ Campbell, E Wright, ...
Haematologica 92 (1), e11-e12, 2007
552007
Manipulation of B-cell responses with histone deacetylase inhibitors
M Waibel, AJ Christiansen, ML Hibbs, J Shortt, SA Jones, I Simpson, ...
Nature communications 6 (1), 1-12, 2015
542015
E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis
K Wolyniec, J Shortt, E de Stanchina, Y Levav-Cohen, O Alsheich-Bartok, ...
Blood, The Journal of the American Society of Hematology 120 (4), 822-832, 2012
542012
BET inhibition induces apoptosis in aggressive B-cell lymphoma via epigenetic regulation of BCL-2 family members
SJ Hogg, A Newbold, SJ Vervoort, LA Cluse, BP Martin, GP Gregory, ...
Molecular cancer therapeutics 15 (9), 2030-2041, 2016
482016
Assessment of the urgency and deferability of transfusion to inform emergency blood planning and triage: the Bloodhound prospective audit of red blood cell use
J Shortt, MN Polizzotto, N Waters, M Borosak, M Moran, M Comande, ...
Transfusion 49 (11), 2296-2303, 2009
452009
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Artikelen 1–20