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MARIA PURA HORTIGON VINAGRE
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Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias
K Blinova, J Stohlman, J Vicente, D Chan, L Johannesen, ...
Toxicological Sciences 155 (1), 234-247, 2017
2442017
The use of ratiometric fluorescence measurements of the voltage sensitive dye Di-4-ANEPPS to examine action potential characteristics and drug effects on human induced …
MP Hortigon-Vinagre, V Zamora, FL Burton, J Green, GA Gintant, ...
Toxicological Sciences 154 (2), 320-331, 2016
992016
Gene therapy with angiotensin-(1-9) preserves left ventricular systolic function after myocardial infarction
C Fattah, K Nather, CS McCarroll, MP Hortigon-Vinagre, V Zamora, ...
Journal of the American College of Cardiology 68 (24), 2652-2666, 2016
502016
2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptosis by disruption of intracellular calcium homeostasis in human neuronal cell line SHSY5Y
A Morales-Hernández, FJ Sánchez-Martín, MP Hortigón-Vinagre, ...
Apoptosis 17 (11), 1170-1181, 2012
472012
Tailoring mathematical models to stem-cell derived cardiomyocyte lines can improve predictions of drug-induced changes to their electrophysiology
CL Lei, K Wang, M Clerx, RH Johnstone, MP Hortigon-Vinagre, V Zamora, ...
Frontiers in physiology 8, 986, 2017
462017
Deconvoluting kinase inhibitor induced cardiotoxicity
SD Lamore, E Ahlberg, S Boyer, ML Lamb, MP Hortigon-Vinagre, ...
Toxicological Sciences 158 (1), 213-226, 2017
382017
Targeted disruption of the heat shock protein 20–phosphodiesterase 4D (PDE4D) interaction protects against pathological cardiac remodelling in a mouse model of hypertrophy
TP Martin, MP Hortigon-Vinagre, JE Findlay, C Elliott, S Currie, GS Baillie
FEBS Open Bio 4, 923-927, 2014
352014
Application of optical action potentials in human induced pluripotent stem cells-derived cardiomyocytes to predict drug-induced cardiac arrhythmias
HR Lu, MP Hortigon-Vinagre, V Zamora, I Kopljar, A De Bondt, ...
Journal of pharmacological and toxicological methods 87, 53-67, 2017
332017
Electrophysiological characterization of drug response in hSC-derived cardiomyocytes using voltage-sensitive optical platforms
ER Pfeiffer-Kaushik, GL Smith, B Cai, GT Dempsey, MP Hortigon-Vinagre, ...
Journal of pharmacological and toxicological methods 99, 106612, 2019
312019
Bioactive Phytochemicals from Mercurialis spp. Used in Traditional Spanish Medicine
J Blanco-Salas, FM Vazquez, MP Hortigón-Vinagre, T Ruiz-Tellez
Plants 8 (7), 193, 2019
172019
Correlation between human ether‐a‐go‐go‐related gene channel inhibition and action potential prolongation
P Saxena, MP Hortigon‐Vinagre, S Beyl, I Baburin, S Andranovits, ...
British journal of pharmacology 174 (18), 3081-3093, 2017
142017
Inhibition by 4-hydroxynonenal (HNE) of Ca2+ transport by SERCA1a: Low concentrations of HNE open protein-mediated leaks in the membrane
MP Hortigón-Vinagre, S Chardonnet, C Montigny, Y Gutiérrez-Martín, ...
Free Radical Biology and Medicine 50 (11), 1700-1713, 2011
132011
Thymbra capitata essential oil prevents cell death induced by 4-hydroxy-2-nonenal in neonatal rat cardiac myocytes
MP Hortigón-Vinagre, J Blanco, T Ruiz, F Henao
Planta medica 80 (15), 1284-1290, 2014
122014
Exercise training reveals micro-RNAs associated with improved cardiac function and electrophysiology in rats with heart failure after myocardial infarction
TO Stølen, MA Høydal, MS Ahmed, K Jørgensen, K Garten, ...
Journal of Molecular and Cellular Cardiology 148, 106-119, 2020
112020
Apoptotic cell death in cultured cardiomyocytes following exposure to low concentrations of 4-hydroxy-2-nonenal
MP Hortigón-Vinagre, F Henao
Cardiovascular toxicology 14 (3), 275-287, 2014
102014
The use of voltage sensitive dye di-4-ANEPPS and video-based contractility measurements to assess drug effects on excitation-contraction coupling in human induced pluripotent …
MP Hortigon-Vinagre, V Zamora, FL Burton, GL Smith
Journal of Cardiovascular Pharmacology, 2020
92020
Measurements of voltage, intracellular Ca2+ and contraction from spontaneous iPSC-derived cardiomyocytes using CellOPTIQ® platform reveals complex effects from drugs that …
MP Hortigon-Vinagre, V Zamora, FL Burton, P Butler, GL Smith
J. Pharmacol. Toxicol. Methods 93, 119-20, 2018
42018
Optical measurements of electrical activity from hiPSC-derived cardiomyocytes is a robust and high-throughput method for measuring NCE-effects on the cardiac action potential
G Smith, MA Craig, B Anson, M Hortigon-Vinagre, F Burton, R Wallis, ...
SOT Annual Meeting, 2013
22013
The influence of fibroblast co-culture and 3D structures on cardiac action potentials of human stem cell derived cardiomyocytes.
MP Hortigon-Vinagre, V Zamora, G Gintant, EK Gallen, J Green, FL Burton, ...
Journal of Pharmacological and Toxicological Methods 93, 169-169, 2018
12018
Characterization of electrical and mechanical functions of Pluricyte® hiPSC-derived cardiomyocytes using the optical platform CellOPTIQ®
MP Hortigon-Vinagre, V Zamora, T de Korte, M Vlaming, S Braam, ...
Journal of Pharmacological and Toxicological Methods 88, 238-239, 2017
12017
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