| An immune-active tumor microenvironment favors clinical response to ipilimumab RR Ji, SD Chasalow, L Wang, O Hamid, H Schmidt, J Cogswell, ... Cancer Immunology, Immunotherapy 61, 1019-1031, 2012 | 840 | 2012 |
| Comparative analysis of proteome and transcriptome variation in mouse A Ghazalpour, B Bennett, VA Petyuk, L Orozco, R Hagopian, IN Mungrue, ... PLoS genetics 7 (6), e1001393, 2011 | 700 | 2011 |
| A high-resolution association mapping panel for the dissection of complex traits in mice BJ Bennett, CR Farber, L Orozco, HM Kang, A Ghazalpour, N Siemers, ... Genome research 20 (2), 281-290, 2010 | 371 | 2010 |
| Genome-wide association analysis identifies genetic correlates of immune infiltrates in solid tumors NO Siemers, JL Holloway, H Chang, SD Chasalow, PB Ross-MacDonald, ... PloS one 12 (7), e0179726, 2017 | 196 | 2017 |
| Insights gained from single-cell analysis of immune cells in the tumor microenvironment X Ren, L Zhang, Y Zhang, Z Li, N Siemers, Z Zhang Annual review of immunology 39, 583-609, 2021 | 176 | 2021 |
| Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages LD Orozco, BJ Bennett, CR Farber, A Ghazalpour, C Pan, N Che, P Wen, ... Cell 151 (3), 658-670, 2012 | 135 | 2012 |
| HBEGF, SRA1, and IK: Three cosegregating genes as determinants of cardiomyopathy F Friedrichs, C Zugck, GJ Rauch, B Ivandic, D Weichenhan, ... Genome research 19 (3), 395-403, 2009 | 120 | 2009 |
| Nearest Neighbor Networks: clustering expression data based on gene neighborhoods C Huttenhower, AI Flamholz, JN Landis, S Sahi, CL Myers, KL Olszewski, ... BMC bioinformatics 8, 1-13, 2007 | 97 | 2007 |
| CD96 Is an Immune Checkpoint That Regulates CD8+ T-cell Antitumor Function D Mittal, A Lepletier, J Madore, AR Aguilera, K Stannard, SJ Blake, ... Cancer immunology research 7 (4), 559-571, 2019 | 90 | 2019 |
| Gene set enrichment analysis CA Tilford, NO Siemers Protein networks and pathway analysis, 99-121, 2009 | 86 | 2009 |
| Fc-optimized anti-CCR8 antibody depletes regulatory T cells in human tumor models JR Campbell, BR McDonald, PB Mesko, NO Siemers, PB Singh, M Selby, ... Cancer Research 81 (11), 2983-2994, 2021 | 72 | 2021 |
| Analyses of PD-L1 and inflammatory gene expression association with efficacy of nivolumab±ipilimumab in gastric cancer/gastroesophageal junction cancer M Lei, NO Siemers, D Pandya, H Chang, T Sanchez, C Harbison, ... Clinical Cancer Research 27 (14), 3926-3935, 2021 | 60 | 2021 |
| Construction, expression, and activities of L49-sFv-β-lactamase, a single-chain antibody fusion protein for anticancer prodrug activation NO Siemers, DE Kerr, S Yarnold, MR Stebbins, VM Vrudhula, I Hellström, ... Bioconjugate chemistry 8 (4), 510-519, 1997 | 55 | 1997 |
| Cephalosporin prodrugs of paclitaxel for immunologically specific activation by L-49-sFv-β-lactamase fusion protein VM Vrudhula, DE Kerr, NO Siemers, GM Dubowchik, PD Senter Bioorganic & medicinal chemistry letters 13 (3), 539-542, 2003 | 54 | 2003 |
| Development and activities of a new melphalan prodrug designed for tumor-selective activation DE Kerr, Z Li, NO Siemers, PD Senter, VM Vrudhula Bioconjugate chemistry 9 (2), 255-259, 1998 | 50 | 1998 |
| Exome sequencing reveals comprehensive genomic alterations across eight cancer cell lines H Chang, DG Jackson, PS Kayne, PB Ross-Macdonald, RP Ryseck, ... PloS one 6 (6), e21097, 2011 | 47 | 2011 |
| Periplanone total synthesis via intramolecular pinacol coupling JE McMurry, NO Siemers Tetrahedron letters 35 (26), 4505-4508, 1994 | 43 | 1994 |
| Construction of a reference gene association network from multiple profiling data: application to data analysis D Ucar, I Neuhaus, P Ross-MacDonald, C Tilford, S Parthasarathy, ... Bioinformatics 23 (20), 2716-2724, 2007 | 42 | 2007 |
| Gene expression analyses of mouse aortic endothelium in response to atherogenic stimuli A Erbilgin, N Siemers, P Kayne, W Yang, J Berliner, AJ Lusis Arteriosclerosis, thrombosis, and vascular biology 33 (11), 2509-2517, 2013 | 38 | 2013 |
| Transcriptional profiling of the dose response: a more powerful approach for characterizing drug activities RR Ji, H de Silva, Y Jin, RE Bruccoleri, J Cao, A He, W Huang, PS Kayne, ... PLoS computational biology 5 (9), e1000512, 2009 | 37 | 2009 |
