Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria JN Spelbrink, FY Li, V Tiranti, K Nikali, QP Yuan, M Tariq, S Wanrooij, ... Nature genetics 28 (3), 223-231, 2001 | 1006 | 2001 |
What causes mitochondrial DNA deletions in human cells? KJ Krishnan, AK Reeve, DC Samuels, PF Chinnery, JK Blackwood, ... Nature genetics 40 (3), 275-279, 2008 | 458 | 2008 |
Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice H Tyynismaa, KP Mjosund, S Wanrooij, I Lappalainen, E Ylikallio, ... Proceedings of the National Academy of Sciences 102 (49), 17687-17692, 2005 | 371 | 2005 |
Mitochondrial RNA polymerase is needed for activation of the origin of light-strand DNA replication JM Fusté, S Wanrooij, E Jemt, CE Granycome, TJ Cluett, Y Shi, ... Molecular cell 37 (1), 67-78, 2010 | 257 | 2010 |
Human mitochondrial RNA polymerase primes lagging-strand DNA synthesis in vitro S Wanrooij, JM Fusté, G Farge, Y Shi, CM Gustafsson, M Falkenberg Proceedings of the National Academy of Sciences 105 (32), 11122-11127, 2008 | 226 | 2008 |
Mammalian transcription factor A is a core component of the mitochondrial transcription machinery Y Shi, A Dierckx, PH Wanrooij, S Wanrooij, NG Larsson, LM Wilhelmsson, ... Proceedings of the National Academy of Sciences 109 (41), 16510-16515, 2012 | 214 | 2012 |
Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells JLO Pohjoismäki, S Wanrooij, AK Hyvärinen, S Goffart, IJ Holt, ... Nucleic acids research 34 (20), 5815-5828, 2006 | 186 | 2006 |
In Vivo Occupancy of Mitochondrial Single-Stranded DNA Binding Protein Supports the Strand Displacement Mode of DNA Replication J Miralles Fusté, Y Shi, S Wanrooij, X Zhu, E Jemt, Ö Persson, N Sabouri, ... PLoS genetics 10 (12), e1004832, 2014 | 159 | 2014 |
Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes S Wanrooij, S Goffart, JLO Pohjoismäki, T Yasukawa, JN Spelbrink Nucleic acids research 35 (10), 3238-3251, 2007 | 156 | 2007 |
Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA … S Goffart, HM Cooper, H Tyynismaa, S Wanrooij, A Suomalainen, ... Human molecular genetics 18 (2), 328-340, 2009 | 151 | 2009 |
The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA AK Hyvärinen, JLO Pohjoismäki, A Reyes, S Wanrooij, T Yasukawa, ... Nucleic acids research 35 (19), 6458-6474, 2007 | 150 | 2007 |
The human mitochondrial replication fork in health and disease S Wanrooij, M Falkenberg Biochimica et Biophysica Acta (BBA)-Bioenergetics 1797 (8), 1378-1388, 2010 | 146 | 2010 |
Twinkle and POLG defects enhance age‐dependent accumulation of mutations in the control region of mtDNA S Wanrooij, P Luoma, G van Goethem, C van Broeckhoven, ... Nucleic acids research 32 (10), 3053-3064, 2004 | 142 | 2004 |
PrimPol is required for replication reinitiation after mtDNA damage R Torregrosa-Muñumer, JME Forslund, S Goffart, A Pfeiffer, G Stojkovič, ... Proceedings of the National Academy of Sciences 114 (43), 11398-11403, 2017 | 88 | 2017 |
ClpX stimulates the mitochondrial unfolded protein response (UPRmt) in mammalian cells N Al-Furoukh, A Ianni, H Nolte, S Hölper, M Krüger, S Wanrooij, T Braun Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1853 (10), 2580-2591, 2015 | 88 | 2015 |
ATPase-deficient mitochondrial inner membrane protein ATAD3A disturbs mitochondrial dynamics in dominant hereditary spastic paraplegia HM Cooper, Y Yang, E Ylikallio, R Khairullin, R Woldegebriel, KL Lin, ... Human molecular genetics 26 (8), 1432-1443, 2017 | 85 | 2017 |
In vivo mutagenesis reveals that OriL is essential for mitochondrial DNA replication S Wanrooij, J Miralles Fusté, JB Stewart, PH Wanrooij, T Samuelsson, ... EMBO reports 13 (12), 1130-1137, 2012 | 79 | 2012 |
Oxidative DNA damage stalls the human mitochondrial replisome G Stojkovič, AV Makarova, PH Wanrooij, J Forslund, PM Burgers, ... Scientific reports 6 (1), 28942, 2016 | 74 | 2016 |
Quinazoline ligands induce cancer cell death through selective STAT3 inhibition and G-quadruplex stabilization J Jamroskovic, M Doimo, K Chand, I Obi, R Kumar, K Brännström, ... Journal of the American Chemical Society 142 (6), 2876-2888, 2020 | 53 | 2020 |
Ribonucleotides incorporated by the yeast mitochondrial DNA polymerase are not repaired PH Wanrooij, MKM Engqvist, JME Forslund, C Navarrete, AK Nilsson, ... Proceedings of the National Academy of Sciences 114 (47), 12466-12471, 2017 | 45 | 2017 |