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Koen Augustyns
Koen Augustyns
Full professor, Medicinal Chemistry, University of Antwerp
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Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family
AM Lambeir, P Proost, C Durinx, G Bal, K Senten, K Augustyns, ...
Journal of Biological Chemistry 276 (32), 29839-29845, 2001
3472001
Truncation of macrophage-derived chemokine by CD26/dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction
P Proost, S Struyf, D Schols, G Opdenakker, S Sozzani, P Allavena, ...
Journal of Biological Chemistry 274 (7), 3988-3993, 1999
2041999
Extended structure–activity relationship and pharmacokinetic investigation of (4-quinolinoyl) glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP)
K Jansen, L Heirbaut, R Verkerk, JD Cheng, J Joossens, P Cos, L Maes, ...
Journal of medicinal chemistry 57 (7), 3053-3074, 2014
2022014
In vitro antioxidant profile of phenolic acid derivatives
P Cos, P Rajan, I Vedernikova, M Calomme, L Pieters, AJ Vlietinck, ...
Free radical research 36 (6), 711-716, 2002
1972002
When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157
D Rojas-Rivera, T Delvaeye, R Roelandt, W Nerinckx, K Augustyns, ...
Cell Death & Differentiation 24 (6), 1100-1110, 2017
1842017
Synthesis and evaluation of caffeic acid amides as antioxidants
P Rajan, I Vedernikova, P Cos, DV Berghe, K Augustyns, A Haemers
Bioorganic & Medicinal Chemistry Letters 11 (2), 215-217, 2001
1792001
Selective inhibitors of fibroblast activation protein (FAP) with a (4-quinolinoyl)-glycyl-2-cyanopyrrolidine scaffold
K Jansen, L Heirbaut, JD Cheng, J Joossens, O Ryabtsova, P Cos, ...
ACS medicinal chemistry letters 4 (5), 491-496, 2013
1762013
Regulation of intestinal permeability: the role of proteases
H Van Spaendonk, H Ceuleers, L Witters, E Patteet, J Joossens, ...
World journal of gastroenterology 23 (12), 2106, 2017
1652017
Fluoro-olefins as peptidomimetic inhibitors of dipeptidyl peptidases
P Van der Veken, K Senten, I Kertèsz, I De Meester, AM Lambeir, ...
Journal of medicinal chemistry 48 (6), 1768-1780, 2005
1502005
Structure− activity relationship of diaryl phosphonate esters as potent irreversible dipeptidyl peptidase IV inhibitors
A Belyaev, X Zhang, K Augustyns, AM Lambeir, I De Meester, ...
Journal of medicinal chemistry 42 (6), 1041-1052, 1999
1471999
Inhibitors of the purine salvage pathway: a valuable approach for antiprotozoal chemotherapy?
M Berg, P Van der Veken, A Goeminne, A Haemers, K Augustyns
Current medicinal chemistry 17 (23), 2456-2481, 2010
1232010
Molecular, functional and structural properties of the prolyl oligopeptidase of Trypanosoma cruzi (POP Tc80), which is required for parasite entry into mammalian cells
IMD Bastos, P Grellier, NF Martins, G Cadavid-Restrepo, ...
Biochemical Journal 388 (1), 29-38, 2005
1232005
Natural substrates of dipeptidyl peptidase IV
I De Meester, C Durinx, G Bal, P Proost, S Struyf, F Goossens, ...
Cellular peptidases in immune functions and diseases 2, 67-87, 2002
1202002
Inhibitors targeting RIPK1/RIPK3: old and new drugs
S Martens, S Hofmans, W Declercq, K Augustyns, P Vandenabeele
Trends in pharmacological sciences 41 (3), 209-224, 2020
1172020
Prolyl oligopeptidase stimulates the aggregation of α-synuclein
I Brandt, M Gérard, K Sergeant, B Devreese, V Baekelandt, K Augustyns, ...
Peptides 29 (9), 1472-1478, 2008
1092008
Novel ferroptosis inhibitors with improved potency and ADME properties
S Hofmans, TV Berghe, L Devisscher, B Hassannia, S Lyssens, ...
Journal of Medicinal Chemistry 59 (5), 2041-2053, 2016
1062016
Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents
K Augustyns, K Amssoms, A Yamani, PK Rajan, A Haemers
Current pharmaceutical design 7 (12), 1117, 2001
1042001
Incorporation of hexose nucleoside analogues into oligonucleotides: synthesis, base-pairing properties and enzymatic stability
K Augustyns, F Vandendriessche, A Van Aerschot, R Busson, C Urbanke, ...
Nucleic acids research 20 (18), 4711-4716, 1992
1001992
Development of irreversible diphenyl phosphonate inhibitors for urokinase plasminogen activator
J Joossens, P Van der Veken, AM Lambeir, K Augustyns, A Haemers
Journal of medicinal chemistry 47 (10), 2411-2413, 2004
992004
ClpP protease, a promising antimicrobial target
C Moreno-Cinos, K Goossens, IG Salado, P Van Der Veken, H De Winter, ...
International journal of molecular sciences 20 (9), 2232, 2019
962019
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