Koen Augustyns
Koen Augustyns
Full professor, Medicinal Chemistry, University of Antwerp
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Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family
AM Lambeir, P Proost, C Durinx, G Bal, K Senten, K Augustyns, ...
Journal of Biological Chemistry 276 (32), 29839-29845, 2001
Truncation of macrophage-derived chemokine by CD26/dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction
P Proost, S Struyf, D Schols, G Opdenakker, S Sozzani, P Allavena, ...
Journal of Biological Chemistry 274 (7), 3988-3993, 1999
Synthesis and evaluation of caffeic acid amides as antioxidants
P Rajan, I Vedernikova, P Cos, DV Berghe, K Augustyns, A Haemers
Bioorganic & Medicinal Chemistry Letters 11 (2), 215-217, 2001
In vitro antioxidant profile of phenolic acid derivatives
P Cos, P Rajan, I Vedernikova, M Calomme, L Pieters, AJ Vlietinck, ...
Free radical research 36 (6), 711-716, 2002
Structure− activity relationship of diaryl phosphonate esters as potent irreversible dipeptidyl peptidase IV inhibitors
A Belyaev, X Zhang, K Augustyns, AM Lambeir, I De Meester, ...
Journal of medicinal chemistry 42 (6), 1041-1052, 1999
Molecular, functional and structural properties of the prolyl oligopeptidase of Trypanosoma cruzi (POP Tc80), which is required for parasite entry into mammalian cells
IMD Bastos, P Grellier, NF Martins, G Cadavid-Restrepo, ...
Biochemical Journal 388 (1), 29-38, 2005
Fluoro-olefins as peptidomimetic inhibitors of dipeptidyl peptidases
P Van der Veken, K Senten, I Kertèsz, I De Meester, AM Lambeir, ...
Journal of medicinal chemistry 48 (6), 1768-1780, 2005
Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents
K Augustyns, K Amssoms, A Yamani, PK Rajan, A Haemers
Current pharmaceutical design 7 (12), 1117, 2001
Natural substrates of dipeptidyl peptidase IV
I De Meester, C Durinx, G Bal, P Proost, S Struyf, F Goossens, ...
Cellular peptidases in immune functions and diseases 2, 67-87, 2002
Development of irreversible diphenyl phosphonate inhibitors for urokinase plasminogen activator
J Joossens, P Van der Veken, AM Lambeir, K Augustyns, A Haemers
Journal of medicinal chemistry 47 (10), 2411-2413, 2004
A new approach towards the synthesis of 3-amino-6-(hetero) arylpyridazines based on palladium catalyzed cross-coupling reactions
BUW Maes, GLF Lemiere, R Dommisse, K Augustyns, A Haemers
Tetrahedron 56 (12), 1777-1781, 2000
Incorporation of hexose nucleoside analogues into oligonucleotides: synthesis, base-pairing properties and enzymatic stability
K Augustyns, F Vandendriessche, A Van Aerschot, R Busson, C Urbanke, ...
Nucleic acids research 20 (18), 4711-4716, 1992
The therapeutic potential of inhibitors of dipeptidyl peptidase IV (DPP IV) and related proline-specific dipeptidyl aminopeptidases
K Augustyns, PV d Veken, K Senten, A Haemers
Current medicinal chemistry 12 (8), 971-998, 2005
Prolyl oligopeptidase stimulates the aggregation of α-synuclein
I Brandt, M Gérard, K Sergeant, B Devreese, V Baekelandt, K Augustyns, ...
Peptides 29 (9), 1472-1478, 2008
Dipeptidyl peptidase IV inhibitors as new therapeutic agents for the treatment of Type 2 diabetes
K Augustyns, P Van der Veken, K Senten, A Haemers
Expert Opinion on Therapeutic Patents 13 (4), 499-510, 2003
Dipeptidyl peptidase 8/9‐like activity in human leukocytes
MB Maes, V Dubois, I Brandt, AM Lambeir, P Van der Veken, K Augustyns, ...
Journal of leukocyte biology 81 (5), 1252-1257, 2007
Kinetic investigation of human dipeptidyl peptidase II (DPPII)-mediated hydrolysis of dipeptide derivatives and its identification as quiescent cell proline dipeptidase (QPP …
MB Maes, AM Lambeir, K Gilany, K Senten, P Van der Veken, B Leiting, ...
Biochemical Journal 386 (2), 315-324, 2005
Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates
P Van der Veken, A Soroka, I Brandt, YS Chen, MB Maes, AM Lambeir, ...
Journal of medicinal chemistry 50 (23), 5568-5570, 2007
Serine proteases, their activity and their synthetic inhibitors
KJL Augustyns, GC Vanhoof, MJF Borloo, IAJ De Meester, FJA Goossens, ...
US Patent 6,090,786, 2000
Expression and spatial heterogeneity of dipeptidyl peptidases in endothelial cells of conduct vessels and capillaries
V Matheeussen, L Baerts, G De Meyer, G De Keulenaer, P Van der Veken, ...
Biological chemistry 392 (3), 189-198, 2011
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