Roberta Faccio
Roberta Faccio
Associate Professor, Dept of Orthopaedic Suregery, Washington University in St Louis
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Vav3 regulates osteoclast function and bone mass
R Faccio, SL Teitelbaum, K Fujikawa, J Chappel, A Zallone, ...
Nature medicine 11 (3), 284-290, 2005
Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells
K Fujikawa, AV Miletic, FW Alt, R Faccio, T Brown, J Hoog, J Fredericks, ...
The Journal of experimental medicine 198 (10), 1595-1608, 2003
c-Fms and the αvβ3 integrin collaborate during osteoclast differentiation
R Faccio, S Takeshita, A Zallone, FP Ross, SL Teitelbaum
The Journal of clinical investigation 111 (5), 749-758, 2003
Oxytocin is an anabolic bone hormone
R Tamma, G Colaianni, L Zhu, A DiBenedetto, G Greco, G Montemurro, ...
Proceedings of the National Academy of Sciences 106 (17), 7149-7154, 2009
PLCγ2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2
D Mao, H Epple, B Uthgenannt, DV Novack, R Faccio
The Journal of clinical investigation 116 (11), 2869-2879, 2006
Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by β3 integrin
R Faccio, DV Novack, A Zallone, FP Ross, SL Teitelbaum
The Journal of cell biology 162 (3), 499-509, 2003
A Glanzmann’s mutation in β3 integrin specifically impairs osteoclast function
X Feng, DV Novack, R Faccio, DS Ory, K Aya, MI Boyer, KP McHugh, ...
The Journal of clinical investigation 107 (9), 1137-1144, 2001
T cells support osteoclastogenesis in an in vitro model derived from human multiple myeloma bone disease: the role of the OPG/TRAIL interaction
S Colucci, G Brunetti, R Rizzi, A Zonno, G Mori, G Colaianni, D Del Prete, ...
Blood 104 (12), 3722-3730, 2004
RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice
S Vaira, M Alhawagri, I Anwisye, H Kitaura, R Faccio, DV Novack
The Journal of clinical investigation 118 (6), 2088-2097, 2008
RelB is the NF-κB subunit downstream of NIK responsible for osteoclast differentiation
S Vaira, T Johnson, AC Hirbe, M Alhawagri, I Anwisye, B Sammut, ...
Proceedings of the National Academy of Sciences 105 (10), 3897-3902, 2008
Cortactin has an essential and specific role in osteoclast actin assembly
S Tehrani, R Faccio, I Chandrasekar, FP Ross, JA Cooper
Molecular biology of the cell 17 (7), 2882-2895, 2006
The HIV protease inhibitor ritonavir blocks osteoclastogenesis and function by impairing RANKL-induced signaling
MWH Wang, S Wei, R Faccio, S Takeshita, P Tebas, WG Powderly, ...
The Journal of clinical investigation 114 (2), 206-213, 2004
Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis
MK Ruhland, AJ Loza, AH Capietto, X Luo, BL Knolhoff, KC Flanagan, ...
Nature communications 7 (1), 1-18, 2016
The interplay between the bone and the immune system
G Mori, P D'Amelio, R Faccio, G Brunetti
Clinical and Developmental Immunology 2013, 2013
Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCγ2 signaling axis in mice
DB Graham, CM Robertson, J Bautista, F Mascarenhas, MJ Diacovo, ...
The Journal of clinical investigation 117 (11), 3445-3452, 2007
TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis
K Otero, M Shinohara, H Zhao, M Cella, S Gilfillan, A Colucci, R Faccio, ...
The Journal of Immunology 188 (6), 2612-2621, 2012
High dose M‐CSF partially rescues the Dap12−/− osteoclast phenotype
R Faccio, W Zou, G Colaianni, SL Teitelbaum, F Patrick Ross
Journal of cellular biochemistry 90 (5), 871-883, 2003
Systematic pan-cancer analysis reveals immune cell interactions in the tumor microenvironment
FS Varn, Y Wang, DW Mullins, S Fiering, C Cheng
Cancer research 77 (6), 1271-1282, 2017
Localization and possible role of two different alpha v beta 3 integrin conformations in resting and resorbing osteoclasts
R Faccio, M Grano, S Colucci, A Villa, G Giannelli, V Quaranta, A Zallone
Journal of cell science 115 (14), 2919-2929, 2002
Osteoclast motility: putting the brakes on bone resorption
DV Novack, R Faccio
Ageing research reviews 10 (1), 54-61, 2011
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