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Pavlo Gilchuk
Pavlo Gilchuk
Verified email at astrazeneca.com
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Year
Potently neutralizing and protective human antibodies against SARS-CoV-2
SJ Zost, P Gilchuk, JB Case, E Binshtein, RE Chen, JP Nkolola, A Schäfer, ...
Nature 584 (7821), 443-449, 2020
10762020
Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition
AJ Greaney, TN Starr, P Gilchuk, SJ Zost, E Binshtein, AN Loes, SK Hilton, ...
Cell host & microbe 29 (1), 44-57. e9, 2021
10362021
Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies
RE Chen, X Zhang, JB Case, ES Winkler, Y Liu, LA VanBlargan, J Liu, ...
Nature medicine 27 (4), 717-726, 2021
9332021
Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein
SJ Zost, P Gilchuk, RE Chen, JB Case, JX Reidy, A Trivette, RS Nargi, ...
Nature medicine 26 (9), 1422-1427, 2020
4682020
Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein
N Suryadevara, S Shrihari, P Gilchuk, LA VanBlargan, E Binshtein, ...
Cell 184 (9), 2316-2331. e15, 2021
3482021
Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection
ES Winkler, P Gilchuk, J Yu, AL Bailey, RE Chen, Z Chong, SJ Zost, ...
Cell 184 (7), 1804-1820. e16, 2021
3092021
High frequency of shared clonotypes in human B cell receptor repertoires
C Soto, RG Bombardi, A Branchizio, N Kose, P Matta, AM Sevy, ...
Nature 566 (7744), 398-402, 2019
2682019
Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail
J Dong, SJ Zost, AJ Greaney, TN Starr, AS Dingens, EC Chen, RE Chen, ...
Nature microbiology 6 (10), 1233-1244, 2021
2362021
In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains
RE Chen, ES Winkler, JB Case, ID Aziati, TL Bricker, A Joshi, TL Darling, ...
Nature 596 (7870), 103-108, 2021
2152021
A site of vulnerability on the influenza virus hemagglutinin head domain trimer interface
S Bangaru, S Lang, M Schotsaert, HA Vanderven, X Zhu, N Kose, ...
Cell 177 (5), 1136-1152. e18, 2019
2002019
Viral acute lower respiratory infections impair CD8+ T cells through PD-1
JJ Erickson, P Gilchuk, AK Hastings, SJ Tollefson, M Johnson, ...
The Journal of clinical investigation 122 (8), 2967-2982, 2012
1892012
Cross-neutralizing and protective human antibody specificities to poxvirus infections
I Gilchuk, P Gilchuk, G Sapparapu, R Lampley, V Singh, N Kose, DL Blum, ...
Cell 167 (3), 684-694. e9, 2016
1572016
Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell
M Puray-Chavez, KM LaPak, TP Schrank, JL Elliott, DP Bhatt, ...
Cell Reports 36 (2), 2021
1262021
Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail
J Dong, SJ Zost, AJ Greaney, TN Starr, AS Dingens, EC Chen, RE Chen, ...
BioRxiv, 2021.01. 27.428529, 2021
1262021
Mucosal Immunization with a pH-Responsive Nanoparticle Vaccine Induces Protective CD8+ Lung-Resident Memory T Cells
FC Knight, P Gilchuk, A Kumar, KW Becker, S Sevimli, ME Jacobson, ...
ACS nano 13 (10), 10939-10960, 2019
1002019
A novel pre-fusion conformation-specific neutralizing epitope on the respiratory syncytial virus fusion protein
JJ Mousa, N Kose, P Matta, P Gilchuk, JE Crowe
Nature microbiology 2 (4), 1-8, 2017
942017
Poly (propylacrylic acid)-peptide nanoplexes as a platform for enhancing the immunogenicity of neoantigen cancer vaccines
F Qiu, KW Becker, FC Knight, JJ Baljon, S Sevimli, D Shae, P Gilchuk, ...
Biomaterials 182, 82-91, 2018
872018
Antibody-dependent enhancement of Ebola virus infection by human antibodies isolated from survivors
NA Kuzmina, P Younan, P Gilchuk, RI Santos, AI Flyak, PA Ilinykh, ...
Cell reports 24 (7), 1802-1815. e5, 2018
842018
A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope
LA VanBlargan, LJ Adams, Z Liu, RE Chen, P Gilchuk, S Raju, BK Smith, ...
Immunity 54 (10), 2399-2416. e6, 2021
832021
Analysis of a therapeutic antibody cocktail reveals determinants for cooperative and broad ebolavirus neutralization
P Gilchuk, CD Murin, JC Milligan, RW Cross, CE Mire, PA Ilinykh, ...
Immunity 52 (2), 388-403. e12, 2020
782020
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