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Aaron Korkegian
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Year
Computational thermostabilization of an enzyme
A Korkegian, ME Black, D Baker, BL Stoddard
Science 308 (5723), 857-860, 2005
4602005
Yeast cytosine deaminase mutants with increased thermostability impart sensitivity to 5-fluorocytosine
TS Stolworthy, AM Korkegian, CL Willmon, A Ardiani, J Cundiff, ...
Journal of molecular biology 377 (3), 854-869, 2008
642008
Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB
LAT Cleghorn, PC Ray, J Odingo, A Kumar, H Wescott, A Korkegian, ...
Journal of Medicinal Chemistry 61 (15), 6592-6608, 2018
562018
The synthesis and evaluation of triazolopyrimidines as anti-tubercular agents
ES Zuniga, A Korkegian, S Mullen, EJ Hembre, PL Ornstein, G Cortez, ...
Bioorganic & Medicinal Chemistry 25 (15), 3922-3946, 2017
522017
A Target-Based Whole Cell Screen Approach To Identify Potential Inhibitors of Mycobacterium tuberculosis Signal Peptidase
SA Bonnett, J Ollinger, S Chandrasekera, S Florio, T O’Malley, M Files, ...
ACS infectious diseases 2 (12), 893-902, 2016
372016
Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA
Y Xia, Y Zhou, DS Carter, MB McNeil, W Choi, J Halladay, PW Berry, ...
Life Science Alliance 1 (3), 2018
342018
The 7-phenyl benzoxaborole series is active against Mycobacterium tuberculosis
A Korkegian, T O'Malley, Y Xia, Y Zhou, DS Carter, B Sunde, L Flint, ...
Tuberculosis 108, 96-98, 2018
292018
Mutations in the essential arabinosyltransferase EmbC lead to alterations in Mycobacterium tuberculosis lipoarabinomannan
A Korkegian, DM Roberts, R Blair, T Parish
Journal of Biological Chemistry 289 (51), 35172-35181, 2014
232014
Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth
PC Ray, M Huggett, PA Turner, M Taylor, LAT Cleghorn, J Early, A Kumar, ...
ACS omega 6 (3), 2284-2311, 2021
192021
8‐Hydroxyquinolines are bactericidal against Mycobacterium tuberculosis
JO Odingo, JV Early, J Smith, J Johnson, MA Bailey, M Files, J Guzman, ...
Drug Development Research 80 (5), 566-572, 2019
192019
Synthesis and biological evaluation of aryl-oxadiazoles as inhibitors of Mycobacterium tuberculosis
MA Martinez-Grau, ICG Valcarcel, JV Early, RK Gessner, CS de Melo, ...
Bioorganic & Medicinal Chemistry Letters 28 (10), 1758-1764, 2018
132018
A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosisIn Vitro
N Patel, T O'Malley, YK Zhang, Y Xia, B Sunde, L Flint, A Korkegian, ...
Antimicrobial Agents and Chemotherapy 61 (9), 10.1128/aac. 01205-17, 2017
132017
Efficacy and improved resistance potential of a cofactor-independent InhA inhibitor of Mycobacterium tuberculosis in the C3HeB/FeJ mouse model
GT Robertson, VA Ektnitphong, MS Scherman, MB McNeil, D Dennison, ...
Antimicrobial Agents and Chemotherapy 63 (4), 10.1128/aac. 02071-18, 2019
122019
Construction of an overexpression library for Mycobacterium tuberculosis
E Melief, R Kokoczka, M Files, MA Bailey, T Alling, H Li, J Ahn, A Misquith, ...
Biology Methods and Protocols 3 (1), bpy009, 2018
122018
InhA inhibitors have activity against non-replicating Mycobacterium tuberculosis
L Flint, A Korkegian, T Parish
PLoS One 15 (11), e0239354, 2020
112020
Mechanisms of resistance against NITD-916, a direct inhibitor of Mycobacterium tuberculosis InhA
MB McNeil, D Dennison, C Shelton, L Flint, A Korkegian, T Parish
Tuberculosis 107, 133-136, 2017
102017
Design, synthesis and SAR of antitubercular benzylpiperazine ureas
S Satish, R Chitral, A Kori, B Sharma, J Puttur, AA Khan, D Desle, ...
Molecular Diversity, 1-24, 2021
62021
Novel chemical entities inhibiting Mycobacterium tuberculosis growth identified by phenotypic high-throughput screening
A Kumar, S Chettiar, BS Brown, J Early, J Ollinger, M Files, MA Bailey, ...
Scientific Reports 12 (1), 14879, 2022
42022
Triazolopyrimidines target aerobic respiration in Mycobacterium tuberculosis
C Shelton, M McNeil, R Allen, L Flint, D Russell, B Berube, A Korkegian, ...
Antimicrobial Agents and Chemotherapy 66 (4), e02041-21, 2022
42022
Identification of 2-amino benzothiazoles with bactericidal activity against Mycobacterium tuberculosis
S Bonnett, JA Jee, S Chettiar, Y Ovechkina, A Korkegian, E Greve, ...
Microbiology Spectrum 11 (1), e04974-22, 2023
12023
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