Aimee M. Deaton
Aimee M. Deaton
Principal Scientist, Alnylam Pharmaceuticals
Geverifieerd e-mailadres voor alnylam.com
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CpG islands and the regulation of transcription
AM Deaton, A Bird
Genes & development 25 (10), 1010-1022, 2011
26772011
CpG islands influence chromatin structure via the CpG-binding protein Cfp1
JP Thomson, PJ Skene, J Selfridge, T Clouaire, J Guy, S Webb, ARW Kerr, ...
Nature 464 (7291), 1082-1086, 2010
6482010
A transient heterochromatic state in Xist preempts X inactivation choice without RNA stabilization
BK Sun, AM Deaton, JT Lee
Molecular cell 21 (5), 617-628, 2006
3472006
Cell type–specific DNA methylation at intragenic CpG islands in the immune system
AM Deaton, S Webb, ARW Kerr, RS Illingworth, J Guy, R Andrews, A Bird
Genome research 21 (7), 1074-1086, 2011
2842011
MNase titration reveals differences between nucleosome occupancy and chromatin accessibility
J Mieczkowski, A Cook, SK Bowman, B Mueller, BH Alver, S Kundu, ...
Nature communications 7 (1), 1-11, 2016
1532016
A temporal threshold for formaldehyde crosslinking and fixation
L Schmiedeberg, P Skene, A Deaton, A Bird
PLoS One 4 (2), e4636, 2009
1092009
Nucleosomal occupancy changes locally over key regulatory regions during cell differentiation and reprogramming
JA West, A Cook, BH Alver, M Stadtfeld, AM Deaton, K Hochedlinger, ...
Nature communications 5 (1), 1-12, 2014
872014
H3K27 modifications define segmental regulatory domains in the Drosophila bithorax complex
SK Bowman, AM Deaton, H Domingues, PI Wang, RI Sadreyev, ...
Elife 3, e02833, 2014
812014
Multiplexed Illumina sequencing libraries from picogram quantities of DNA
SK Bowman, MD Simon, AM Deaton, M Tolstorukov, ML Borowsky, ...
BMC genomics 14 (1), 1-7, 2013
702013
Enhancer regions show high histone H3. 3 turnover that changes during differentiation
AM Deaton, M Gomez-Rodriguez, J Mieczkowski, MY Tolstorukov, ...
elife 5, e15316, 2016
572016
A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells
PC Cook, H Owen, AM Deaton, JG Borger, SL Brown, T Clouaire, ...
Nature communications 6 (1), 1-11, 2015
532015
A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis
RP Kristjansson, S Benonisdottir, OB Davidsson, A Oddsson, V Tragante, ...
Nature genetics 51 (2), 267-276, 2019
352019
Specificity of Atonal and Scute bHLH factors: analysis of cognate E box binding sites and the influence of Senseless
LM Powell, AM Deaton, MA Wear, AP Jarman
Genes to Cells 13 (9), 915-929, 2008
302008
A unique DNA methylation signature defines a population of IFN‐γ/IL‐4 double‐positive T cells during helminth infection
AM Deaton, PC Cook, D De Sousa, AT Phythian‐Adams, A Bird, ...
European journal of immunology 44 (6), 1835-1841, 2014
272014
Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects
PA Nguyen, DA Born, AM Deaton, P Nioi, LD Ward
Nature communications 10 (1), 1-11, 2019
262019
Genome-wide association meta-analysis yields 20 loci associated with gallstone disease
E Ferkingstad, A Oddsson, S Gretarsdottir, S Benonisdottir, G Thorleifsson, ...
Nature communications 9 (1), 1-11, 2018
212018
Nonclinical cardiovascular safety evaluation of romosozumab, an inhibitor of sclerostin for the treatment of osteoporosis in postmenopausal women at high risk of fracture
JR Turk, AM Deaton, J Yin, M Stolina, M Felx, G Boyd, JG Bienvenu, ...
Regulatory Toxicology and Pharmacology 115, 104697, 2020
122020
Sequence variants associating with urinary biomarkers
S Benonisdottir, RP Kristjansson, A Oddsson, V Steinthorsdottir, ...
Human molecular genetics 28 (7), 1199-1211, 2019
122019
Rationalizing secondary pharmacology screening using human genetic and pharmacological evidence
AM Deaton, F Fan, W Zhang, PA Nguyen, LD Ward, P Nioi
Toxicological Sciences 167 (2), 593-603, 2019
42019
A rare missense variant in NR1H4 associates with lower cholesterol levels
AM Deaton, P Sulem, P Nioi, S Benonisdottir, LD Ward, OB Davidsson, ...
Communications biology 1 (1), 1-9, 2018
32018
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Artikelen 1–20