Fels Institute, Temple University School of Medicine
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Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs)
X Graña, EP Reddy
Oncogene 11 (2), 211-220, 1995
Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth
X Graña, J Garriga, X Mayol
Oncogene 17 (25), 3365-3383, 1998
Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain.
X Mayol, X Grana, A Baldi, N Sang, Q Hu, A Giordano
Oncogene 8 (9), 2561-2566, 1993
PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro
X Grana, A De Luca, N Sang, Y Fu, PP Claudio, J Rosenblatt, DO Morgan, ...
Proceedings of the National Academy of Sciences 91 (9), 3834-3838, 1994
Cellular control of gene expression by T-type cyclin/CDK9 complexes
J Garriga, X Graña
Gene 337, 15-23, 2004
The ability of positive transcription elongation factor B to transactivate human immunodeficiency virus transcription depends on a functional kinase domain, cyclin T1, and Tat
K Fujinaga, TP Cujec, J Peng, J Garriga, DH Price, X Graña, BM Peterlin
Journal of virology 72 (9), 7154-7159, 1998
Cell cycle-dependent phosphorylation of the retinoblastoma-related protein p130.
X Mayol, J Garriga, X Graña
Oncogene 11 (4), 801-808, 1995
Upregulation of cyclin T1/CDK9 complexes during T cell activation
J Garriga, J Peng, M Parreño, DH Price, EE Henderson, X Graña
Oncogene 17 (24), 3093-3102, 1998
Dissection of the genetic programs of p53-mediated G1 growth arrest and apoptosis: blocking p53-induced apoptosis unmasks G1 arrest
C Guillouf, X Grana, M Selvakumaran, A De Luca, A Giordano, B Hoffman, ...
Cyclin-dependent kinase 4 expression is essential for neu-induced breast tumorigenesis
HKDL Reddy, RV Mettus, SG Rane, X Graña, J Litvin, EP Reddy
Cancer research 65 (22), 10174-10178, 2005
Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells
DB Rivadeneira, CN Mayhew, C Thangavel, E Sotillo, CA Reed, X Graña, ...
Gastroenterology 138 (5), 1920-1930. e2, 2010
G1 cyclin/CDK-independent phosphorylation and accumulation of p130 during the transition from G1 to G0 lead to its association with E2F-4.
X Mayol, J Garriga, X Graña
Oncogene 13 (2), 237-246, 1996
SKP2 associates with p130 and accelerates p130 ubiquitylation and degradation in human cells
S Bhattacharya, J Garriga, J Calbo, T Yong, DS Haines, X Grana
Oncogene 22 (16), 2443-2451, 2003
G1 cyclin/cyclin-dependent kinase-coordinated phosphorylation of endogenous pocket proteins differentially regulates their interactions with E2F4 and E2F1 and gene expression
J Calbó, M Parreño, E Sotillo, T Yong, A Mazo, J Garriga, X Graña
Journal of Biological Chemistry 277 (52), 50263-50274, 2002
Correlation between E2F-1 requirement in the S phase and E2F-1 transactivation of cell cycle-related genes in human cells
A Sala, NC Nicolaides, A Engelhard, T Bellon, DC Lawe, A Arnold, ...
Cancer research 54 (6), 1402-1406, 1994
The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19.
RS Yeung, DW Bell, JR Testa, X Mayol, A Baldi, X Grana, K Klinga-Levan, ...
Oncogene 8 (12), 3465-3468, 1993
CDK9 is constitutively expressed throughout the cell cycle, and its steady-state expression is independent of SKP2
J Garriga, S Bhattacharya, J Calbó, RM Marshall, M Truongcao, ...
Molecular and cellular biology 23 (15), 5165-5173, 2003
Differential regulation of the retinoblastoma family of proteins during cell proliferation and differentiation
J Garriga, A Limón, X Mayol, SG Rane, JH Albrecht, EP Reddy, V Andrés, ...
Biochemical Journal 333 (3), 645-654, 1998
Transcription of histone H4, H3, and H1 cell cycle genes: promoter factor HiNF-D contains CDC2, cyclin A, and an RB-related protein
AJ Van Wijnen, F AzIz, X Grana, A De Luca, RK Desai, K Jaarsveld, ...
Proceedings of the National Academy of Sciences 91 (26), 12882-12886, 1994
Targeting CDK9 reactivates epigenetically silenced genes in cancer
H Zhang, S Pandey, M Travers, H Sun, G Morton, J Madzo, W Chung, ...
Cell 175 (5), 1244-1258. e26, 2018
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