Pierre Lebrun
Pierre Lebrun
University of Liège, Pharmalex
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Innovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoids in cannabis plant material
B De Backer, B Debrus, P Lebrun, L Theunis, N Dubois, L Decock, ...
Journal of Chromatography B 877 (32), 4115-4124, 2009
Design spaces for analytical methods
E Rozet, P Lebrun, P Hubert, B Debrus, B Boulanger
TrAC Trends in Analytical Chemistry 42, 157-167, 2013
Design space approach in the optimization of the spray-drying process
P Lebrun, F Krier, J Mantanus, H Grohganz, M Yang, E Rozet, ...
European Journal of Pharmaceutics and Biopharmaceutics 80 (1), 226-234, 2012
Moisture content determination of pharmaceutical pellets by near infrared spectroscopy: method development and validation
J Mantanus, E Ziémons, P Lebrun, E Rozet, R Klinkenberg, B Streel, ...
Analytica chimica acta 642 (1), 186-192, 2009
‘Quality by Design’approach for the analysis of impurities in pharmaceutical drug products and drug substances
A Dispas, HT Avohou, P Lebrun, P Hubert, C Hubert
TrAC Trends in Analytical Chemistry 101, 24-33, 2018
Development of a new predictive modelling technique to find with confidence equivalence zone and design space of chromatographic analytical methods
P Lebrun, B Govaerts, B Debrus, A Ceccato, G Caliaro, P Hubert, ...
Chemometrics and Intelligent Laboratory Systems 91 (1), 4-16, 2008
Innovative high-performance liquid chromatography method development for the screening of 19 antimalarial drugs based on a generic approach, using design of experiments …
B Debrus, P Lebrun, JM Kindenge, F Lecomte, A Ceccato, G Caliaro, ...
Journal of Chromatography A 1218 (31), 5205-5215, 2011
Application of new methodologies based on design of experiments, independent component analysis and design space for robust optimization in liquid chromatography
B Debrus, P Lebrun, A Ceccato, G Caliaro, E Rozet, I Nistor, R Oprean, ...
Analytica chimica acta 691 (1-2), 33-42, 2011
Acetaminophen determination in low-dose pharmaceutical syrup by NIR spectroscopy
E Ziémons, J Mantanus, P Lebrun, E Rozet, B Evrard, P Hubert
Journal of pharmaceutical and biomedical analysis 53 (3), 510-516, 2010
Improvement of a stability-indicating method by Quality-by-Design versus Quality-by-Testing: A case of a learning process
C Hubert, P Lebrun, S Houari, E Ziemons, E Rozet, P Hubert
Journal of pharmaceutical and biomedical analysis 88, 401-409, 2014
Continuous production of itraconazole-based solid dispersions by hot melt extrusion: preformulation, optimization and design space determination
J Thiry, P Lebrun, C Vinassa, M Adam, L Netchacovitch, E Ziemons, ...
International journal of pharmaceutics 515 (1-2), 114-124, 2016
Active content determination of non-coated pharmaceutical pellets by near infrared spectroscopy: Method development, validation and reliability evaluation
J Mantanus, E Ziemons, P Lebrun, E Rozet, R Klinkenberg, B Streel, ...
Talanta 80 (5), 1750-1757, 2010
Towards a full integration of optimization and validation phases: An analytical-quality-by-design approach
C Hubert, S Houari, E Rozet, P Lebrun, P Hubert
Journal of Chromatography A 1395, 88-98, 2015
A new criterion to assess distributional homogeneity in hyperspectral images of solid pharmaceutical dosage forms
PY Sacré, P Lebrun, PF Chavez, CD Bleye, L Netchacovitch, E Rozet, ...
Analytica chimica acta 818, 7-14, 2014
Quantitative determination of salbutamol sulfate impurities using achiral supercritical fluid chromatography
A Dispas, V Desfontaine, B Andri, P Lebrun, D Kotoni, A Clarke, ...
Journal of Pharmaceutical and Biomedical Analysis 134, 170-180, 2017
Optimization of a PGSS process for a fenofibrate lipid-based solid dispersion formulation
A Pestieau, F Krier, P Lebrun, B Evrard
18th Forum of Pharmaceutical Sciences, 2015
Optimization of a PGSS (particles from gas saturated solutions) process for a fenofibrate lipid-based solid dispersion formulation
A Pestieau, F Krier, P Lebrun, A Brouwers, B Streel, B Evrard
International journal of pharmaceutics 485 (1-2), 295-305, 2015
Evaluation of the quantitative performances of supercritical fluid chromatography: from method development to validation
A Dispas, P Lebrun, E Ziemons, R Marini, E Rozet, P Hubert
Journal of Chromatography A 1353, 78-88, 2014
Optimization and validation of a fast supercritical fluid chromatography method for the quantitative determination of vitamin D3 and its related impurities
B Andri, P Lebrun, A Dispas, R Klinkenberg, B Streel, E Ziemons, ...
Journal of Chromatography A 1491, 171-181, 2017
Innovative green supercritical fluid chromatography development for the determination of polar compounds
A Dispas, P Lebrun, P Sassiat, E Ziemons, D Thiébaut, J Vial, P Hubert
Journal of Chromatography A 1256, 253-260, 2012
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