Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro I Malet, O Delelis, MA Valantin, B Montes, C Soulie, M Wirden, ... Antimicrobial agents and chemotherapy 52 (4), 1351-1358, 2008 | 347 | 2008 |
Structure and NLO properties of layered bimetallic oxalato-bridged ferromagnetic networks containing stilbazolium-shaped chromophores S Bénard, P Yu, JP Audière, E Rivière, R Clément, J Guilhem, ... Journal of the American Chemical Society 122 (39), 9444-9454, 2000 | 211 | 2000 |
The G140S mutation in HIV integrases from raltegravir-resistant patients rescues catalytic defect due to the resistance Q148H mutation O Delelis, I Malet, L Na, L Tchertanov, V Calvez, AG Marcelin, F Subra, ... Nucleic Acids Research 37 (4), 1193-1201, 2009 | 165 | 2009 |
HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia JB Arlet, JA Ribeil, F Guillem, O Negre, A Hazoume, G Marcion, ... Nature 514 (7521), 242-246, 2014 | 146 | 2014 |
Resistance to HIV-1 integrase inhibitors: a structural perspective JF Mouscadet, O Delelis, AG Marcelin, L Tchertanov Drug Resistance Updates 13 (4-5), 139-150, 2010 | 100 | 2010 |
Impact of Y143 HIV-1 Integrase Mutations on Resistance to Raltegravir In Vitro and In Vivo O Delelis, S Thierry, F Subra, F Simon, I Malet, C Alloui, S Sayon, ... Antimicrobial agents and chemotherapy 54 (1), 491-501, 2010 | 99 | 2010 |
Quasispecies variant dynamics during emergence of resistance to raltegravir in HIV-1-infected patients I Malet, O Delelis, C Soulie, M Wirden, L Tchertanov, P Mottaz, G Peytavin, ... Journal of antimicrobial chemotherapy 63 (4), 795-804, 2009 | 99 | 2009 |
Aminopyridine iron catecholate complexes as models for intradiol catechol dioxygenases. Synthesis, structure, reactivity, and spectroscopic studies P Mialane, L Tchertanov, F Banse, J Sainton, JJ Girerd Inorganic Chemistry 39 (12), 2440-2444, 2000 | 92 | 2000 |
Mutation D816V alters the internal structure and dynamics of c-KIT receptor cytoplasmic region: implications for dimerization and activation mechanisms E Laine, I Chauvot de Beauchêne, D Perahia, C Auclair, L Tchertanov PLoS computational biology 7 (6), e1002068, 2011 | 80 | 2011 |
Allosteric communication across the native and mutated KIT receptor tyrosine kinase E Laine, C Auclair, L Tchertanov Public Library of Science 8 (8), e1002661, 2012 | 74 | 2012 |
Target recognition by catechols and β-ketoenols: Potential contribution of hydrogen bonding and Mn/Mg chelation to HIV-1 integrase inhibition L Tchertanov, JF Mouscadet Journal of medicinal chemistry 50 (6), 1133-1145, 2007 | 70 | 2007 |
Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and mastocytosis: possible new targets of therapy S Bibi, MD Arslanhan, F Langenfeld, S Jeanningros, S Cerny-Reiterer, ... Haematologica 99 (3), 417, 2014 | 65 | 2014 |
Raltegravir: molecular basis of its mechanism of action JF Mouscadet, L Tchertanov European journal of medical research 14, 1-12, 2009 | 64 | 2009 |
Antimitotic agents interacting with tubulin: Synthesis and structure-activity relationships of novel ortho bridged biphenyls of the rhazinilam type C Pascal, J Dubois, D Guénard, L Tchertanov, S Thoret, F Guéritte Tetrahedron 54 (49), 14737-14756, 1998 | 62 | 1998 |
Genetic barriers for integrase inhibitor drug resistance in HIV type-1 B and CRF02_AG subtypes AI Maïga, I Malet, C Soulie, A Derache, V Koita, B Amellal, L Tchertanov, ... Antiviral therapy 14 (1), 123-129, 2009 | 58 | 2009 |
New cytotoxic flavonoids from Cryptocarya infectoria V Dumontet, C Gaspard, N Van Hung, J Fahy, L Tchertanov, T Sévenet, ... Tetrahedron 57 (29), 6189-6196, 2001 | 57 | 2001 |
X-ray investigation of glyoxime derivatives. V. Two isomers of 2-(thienyl) glyoxime. A database study of the geometry and hydrogen bonding of the oxime group L Chertanova, C Pascard, A Sheremetev Acta Crystallographica Section B: Structural Science 50 (6), 708-716, 1994 | 57 | 1994 |
Mononuclear Fe(II) and Fe(III) complexes with the tetradentate ligand N,N′-bisbenzyl-N,N′-bis(2-pyridylmethyl)-ethane-1,2-diamine. Synthesis and … J Simaan, S Poussereau, G Blondin, JJ Girerd, D Defaye, C Philouze, ... Inorganica Chimica Acta 299 (2), 221-230, 2000 | 56 | 2000 |
Novel approaches to treating advanced systemic mastocytosis JA Gilreath, L Tchertanov, MW Deininger Clinical pharmacology: advances and applications, 77-92, 2019 | 54 | 2019 |
D-ring substituted rhazinilam analogues: semisynthesis and evaluation of antitubulin activity C Dupont, D Guénard, L Tchertanov, S Thoret, F Guéritte Bioorganic & medicinal chemistry 7 (12), 2961-2969, 1999 | 50 | 1999 |