GPI-anchored proteins are organized in submicron domains at the cell surface R Varma, S Mayor Nature 394 (6695), 798-801, 1998 | 1497 | 1998 |
T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster R Varma, G Campi, T Yokosuka, T Saito, ML Dustin Immunity 25 (1), 117-127, 2006 | 987 | 2006 |
Nanoscale organization of multiple GPI-anchored proteins in living cell membranes P Sharma, R Varma, RC Sarasij, K Gousset, G Krishnamoorthy, M Rao, ... Cell 116 (4), 577-589, 2004 | 896 | 2004 |
Actin and agonist MHC–peptide complex–dependent T cell receptor microclusters as scaffolds for signaling G Campi, R Varma, ML Dustin The Journal of experimental medicine 202 (8), 1031-1036, 2005 | 759 | 2005 |
The immunological synapse balances T cell receptor signaling and degradation KH Lee, AR Dinner, C Tu, G Campi, S Raychaudhuri, R Varma, TN Sims, ... science 302 (5648), 1218-1222, 2003 | 664 | 2003 |
Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins V Heissmeyer, F Macián, SH Im, R Varma, S Feske, K Venuprasad, H Gu, ... Nature immunology 5 (3), 255-265, 2004 | 612 | 2004 |
Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells Y Kaizuka, AD Douglass, R Varma, ML Dustin, RD Vale Proceedings of the National Academy of Sciences 104 (51), 20296-20301, 2007 | 426 | 2007 |
Opposing effects of PKCθ and WASp on symmetry breaking and relocation of the immunological synapse TN Sims, TJ Soos, HS Xenias, B Dubin-Thaler, JM Hofman, JC Waite, ... Cell 129 (4), 773-785, 2007 | 408 | 2007 |
Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes D Skokos, G Shakhar, R Varma, JC Waite, TO Cameron, RL Lindquist, ... Nature immunology 8 (8), 835-844, 2007 | 236 | 2007 |
Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance DC Palmer, GC Guittard, Z Franco, JG Crompton, RL Eil, SJ Patel, Y Ji, ... Journal of Experimental Medicine 212 (12), 2095-2113, 2015 | 188 | 2015 |
Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster S Vardhana, K Choudhuri, R Varma, ML Dustin Immunity 32 (4), 531-540, 2010 | 188 | 2010 |
Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain AM Beal, N Anikeeva, R Varma, TO Cameron, G Vasiliver-Shamis, ... Immunity 31 (4), 632-642, 2009 | 139 | 2009 |
T cell–dendritic cell immunological synapses ML Dustin, SY Tseng, R Varma, G Campi Current opinion in immunology 18 (4), 512-516, 2006 | 121 | 2006 |
Supported planar bilayers for study of the immunological synapse ML Dustin, T Starr, R Varma, VK Thomas Current protocols in immunology 76 (1), 18.13. 1-18.13. 35, 2007 | 104 | 2007 |
The Class II Phosphatidylinositol 3 kinase C2β Is Required for the Activation of the K+ Channel KCa3.1 and CD4 T-Cells S Srivastava, L Di, O Zhdanova, Z Li, S Vardhana, Q Wan, Y Yan, ... Molecular biology of the cell 20 (17), 3783-3791, 2009 | 90 | 2009 |
Endogenous viral antigen processing generates peptide-specific MHC class I cell-surface clusters X Lu, JS Gibbs, HD Hickman, A David, BP Dolan, Y Jin, DM Kranz, ... Proceedings of the National Academy of Sciences 109 (38), 15407-15412, 2012 | 83 | 2012 |
Protein kinase Cθ regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL AM Beal, N Anikeeva, R Varma, TO Cameron, PJ Norris, ML Dustin, ... The Journal of Immunology 181 (7), 4815-4824, 2008 | 76 | 2008 |
Dissection of specific binding of HIV-1 Gag to the'packaging signal'in viral RNA M Comas-Garcia, SAK Datta, L Baker, R Varma, PR Gudla, A Rein Elife 6, e27055, 2017 | 68 | 2017 |
Fluorescence methods to probe nanometer-scale organization of molecules in living cell membranes RV Krishnan, R Varma, S Mayor Journal of fluorescence 11, 211-226, 2001 | 61 | 2001 |
Bispecific heterodimeric fusion proteins containing IL-15-IL-15Rα Fc-fusion proteins and PD-1 antibody fragments M Bernett, R Rashid, J Desjarlais, R Varma, C Bonzon US Patent 10,550,185, 2020 | 59 | 2020 |