Programmed DNA destruction by miniature CRISPR-Cas14 enzymes LB Harrington, D Burstein, JS Chen, D Paez-Espino, E Ma, IP Witte, ... Science 362 (6416), 839-842, 2018 | 891 | 2018 |
CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks JC Cofsky, D Karandur, CJ Huang, IP Witte, J Kuriyan, JA Doudna Elife 9, e55143, 2020 | 75 | 2020 |
A scoutRNA is required for some type V CRISPR-Cas systems LB Harrington, E Ma, JS Chen, IP Witte, D Gertz, D Paez-Espino, ... Molecular cell 79 (3), 416-424. e5, 2020 | 60 | 2020 |
Site-specific lipidation enhances IFITM3 membrane interactions and antiviral activity EH Garst, H Lee, T Das, S Bhattacharya, A Percher, R Wiewiora, IP Witte, ... ACS chemical biology 16 (5), 844-856, 2021 | 25 | 2021 |
Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection LB Harrington, JS Chen, JP Broughton, PPD Galarza, WJ Hartono, ... US Patent 11,174,470, 2021 | 8 | 2021 |
eld and JA Doudna LB Harrington, D Burstein, JS Chen, D Paez-Espino, E Ma, IP Witte, ... Science 362, 839-842, 2018 | 8 | 2018 |
COMPOSITIONS AND METHODS FOR DETECTING MODIFIED NUCLEIC ACIDS AND AMPLIFYING ssDNA LB Harrington, JS Chen, JP Broughton, IP Witte US Patent App. 17/365,967, 2022 | | 2022 |
Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection LB Harrington, JS Chen, JP Broughton, PPD Galarza, WJ Hartono, ... US Patent App. 17/495,652, 2022 | | 2022 |
Programmable nucleases and methods of use LB Harrington, JS Chen, IP Witte US Patent App. 17/516,027, 2022 | | 2022 |