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Nicholas P Marotta
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O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease
NP Marotta, YH Lin, YE Lewis, MR Ambroso, BW Zaro, MT Roth, ...
Nature chemistry 7 (11), 913-920, 2015
2742015
Semisynthetic, site-specific ubiquitin modification of α-synuclein reveals differential effects on aggregation
F Meier, T Abeywardana, A Dhall, NP Marotta, J Varkey, R Langen, ...
Journal of the American Chemical Society 134 (12), 5468-5471, 2012
1222012
O-GlcNAc modification prevents peptide-dependent acceleration of α-synuclein aggregation.
NP Marotta, CA Cherwien, T Abeywardana, MR Pratt
Chembiochem: a European journal of chemical biology 13 (18), 2665-2670, 2012
742012
The new chemical reporter 6-alkynyl-6-deoxy-GlcNAc reveals O-GlcNAc modification of the apoptotic caspases that can block the cleavage/activation of caspase-8
KN Chuh, AR Batt, BW Zaro, N Darabedian, NP Marotta, CK Brennan, ...
Journal of the American Chemical Society 139 (23), 7872-7885, 2017
612017
N-terminal protein modification using simple aminoacyl transferase substrates
AM Wagner, MW Fegley, JB Warner, CLJ Grindley, NP Marotta, ...
Journal of the American Chemical Society 133 (38), 15139-15147, 2011
472011
Alpha-synuclein from patient Lewy bodies exhibits distinct pathological activity that can be propagated in vitro
NP Marotta, J Ara, N Uemura, MG Lougee, ES Meymand, B Zhang, ...
Acta neuropathologica communications 9, 1-18, 2021
362021
O-GlcNAc modification inhibits the calpain-mediated cleavage of α-synuclein
PM Levine, CA De Leon, A Galesic, A Balana, NP Marotta, YE Lewis, ...
Bioorganic & medicinal chemistry 25 (18), 4977-4982, 2017
352017
Synthetic proteins and peptides for the direct interrogation of α-synuclein posttranslational modifications
MR Pratt, T Abeywardana, NP Marotta
Biomolecules 5 (3), 1210-1227, 2015
212015
O‑GlcNAc modification blocks the aggregation and toxicity of the protein α‑synuclein associated with Parkinson’s disease. Nat Chem. 2015; 7: 913–20
NP Marotta, YH Lin, YE Lewis, MR Ambroso, BW Zaro, MT Roth, ...
7
Modeling the cellular fate of alpha-synuclein aggregates: A pathway to pathology
NP Marotta, VMY Lee
Current opinion in neurobiology 72, 171-177, 2022
52022
α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice
N Uemura, NP Marotta, J Ara, ES Meymand, B Zhang, H Kameda, ...
Nature Communications 14 (1), 6892, 2023
32023
Distinct biological activity of Lewy body α-Synuclein strain in mice
N Uemura, N Marotta, J Ara, E Meymand, B Zhang, H Kameda, M Koike, ...
Research Square, 2023
32023
Uncovering the Protective Role of Protein Glycosylation in Parkinson's Disease Utilizing Protein Semi-synthesis
NP Marotta
University of Southern California, 2015
12015
MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons
H Xu, Q Qiu, P Hu, K Hoxha, E Jang, M O’Reilly, C Kim, Z He, N Marotta, ...
Acta Neuropathologica 147 (1), 55, 2024
2024
Selected publications
W Fu, LS Wang, SY Chou, H Xu, Q Qiu, P Hu, K Hoxha, E Jang, M O'Reilly, ...
Soc Sci Med 348 (116849), 38581815, 2024
2024
Highly tunable bimane-based fluorescent probes: design, synthesis, and application as a selective amyloid binding dye
Y Venkatesh, NP Marotta, VMY Lee, EJ Petersson
Chemical Science 15 (16), 6053-6063, 2024
2024
O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein
NP Marotta, YH Lin, YE Lewis
Nature, 2015
2015
Differential effects of site-specific sumoylation on alpha-synuclein aggregation
TJ Abeywardana, NP Marotta, MR Pratt
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 248, 2014
2014
O-GlcNAc modification prevents peptide-dependent acceleration of a-synuclein aggregation
NP Marotta, CA Cherwien, T Abeywardana, MR Pratt
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 245, 2013
2013
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