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Professor Margaret Ashcroft
Professor Margaret Ashcroft
Geverifieerd e-mailadres voor medschl.cam.ac.uk
Titel
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Jaar
Regulation of p53 function and stability by phosphorylation
M Ashcroft, MHG Kubbutat, KH Vousden
Molecular and cellular biology 19 (3), 1751-1758, 1999
6031999
Regulation of p53 stability
M Ashcroft, KH Vousden
Oncogene 18 (53), 7637-7643, 1999
5961999
Stress signals utilize multiple pathways to stabilize p53
M Ashcroft, Y Taya, KH Vousden
Molecular and cellular biology 20 (9), 3224-3233, 2000
4842000
Role of hypoxia-inducible factor (HIF)-1α versus HIF-2α in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau …
VA Carroll, M Ashcroft
Cancer research 66 (12), 6264-6270, 2006
4462006
Negative and positive regulation of HIF-1: a complex network
JI Bárdos, M Ashcroft
Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1755 (2), 107-120, 2005
4362005
A ribonucleotide reductase gene is a transcriptional target of p53 and p73
K Nakano, É Bálint, M Ashcroft, KH Vousden
Oncogene 19 (37), 4283-4289, 2000
3022000
Targeting the hypoxia-inducible factor (HIF) pathway in cancer
E Poon, AL Harris, M Ashcroft
Expert reviews in molecular medicine 11, e26, 2009
2942009
Hypoxia‐inducible factor‐1 and oncogenic signalling
JI Bárdos, M Ashcroft
Bioessays 26 (3), 262-269, 2004
2872004
Regulation of Mdm2-directed degradation by the C terminus of p53
MHG Kubbutat, RL Ludwig, M Ashcroft, KH Vousden
Molecular and cellular biology 18 (10), 5690-5698, 1998
2801998
Identification of a cryptic nucleolar-localization signal in MDM2
MAE Lohrum, M Ashcroft, MHG Kubbutat, KH Vousden
Nature cell biology 2 (3), 179-181, 2000
2522000
Phosphorylation of HDM2 by Akt
M Ashcroft, RL Ludwig, DB Woods, TD Copeland, HO Weber, EJ MacRae, ...
Oncogene 21 (13), 1955-1962, 2002
2402002
HIF-1 reduces ischaemia–reperfusion injury in the heart by targeting the mitochondrial permeability transition pore
SG Ong, WH Lee, L Theodorou, K Kodo, SY Lim, DH Shukla, T Briston, ...
Cardiovascular research 104 (1), 24-36, 2014
1832014
Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1α …
NM Chau, P Rogers, W Aherne, V Carroll, I Collins, E McDonald, ...
Cancer Research 65 (11), 4918-4928, 2005
1822005
Exploring the molecular interface between hypoxia-inducible factor signalling and mitochondria
LW Thomas, M Ashcroft
Cellular and Molecular Life Sciences 76, 1759-1777, 2019
1802019
Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-κB pathway and is dependent on p53 phosphorylation
CA Pise-Masison, R Mahieux, H Jiang, M Ashcroft, M Radonovich, ...
Molecular and Cellular Biology 20 (10), 3377-3386, 2000
1802000
Role of the phosphatidylinositol-3-kinase and extracellular regulated kinase pathways in the induction of hypoxia-inducible factor (HIF)-1 activity and the HIF-1 target …
H Alam, J Weck, E Maizels, Y Park, EJ Lee, M Ashcroft, ...
Endocrinology 150 (2), 915-928, 2009
1452009
Contribution of two independent MDM2-binding domains in p14ARF to p53 stabilization
MAE Lohrum, M Ashcroft, MHG Kubbutat, KH Vousden
Current Biology 10 (9), 539-542, 2000
1362000
Hypoxic regulation of telomerase gene expression by transcriptional and post-transcriptional mechanisms
CJ Anderson, SF Hoare, M Ashcroft, AE Bilsland, WN Keith
Oncogene 25 (1), 61-69, 2006
1302006
Targeting the molecular basis for tumour hypoxia
VA Carroll, M Ashcroft
Expert reviews in molecular medicine 7 (6), 1-16, 2005
1292005
Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium
EO Pettersen, P Ebbesen, RG Gieling, KJ Williams, L Dubois, P Lambin, ...
Journal of enzyme inhibition and medicinal chemistry 30 (5), 689-721, 2015
1252015
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Artikelen 1–20