The allelic landscape of human blood cell trait variation and links to common complex disease WJ Astle, H Elding, T Jiang, D Allen, D Ruklisa, AL Mann, D Mead, ... Cell 167 (5), 1415-1429. e19, 2016 | 1165 | 2016 |
Lineage-specific genome architecture links enhancers and non-coding disease variants to target gene promoters BM Javierre, OS Burren, SP Wilder, R Kreuzhuber, SM Hill, S Sewitz, ... Cell 167 (5), 1369-1384. e19, 2016 | 960 | 2016 |
Genetic drivers of epigenetic and transcriptional variation in human immune cells L Chen, B Ge, FP Casale, L Vasquez, T Kwan, D Garrido-Martín, S Watt, ... Cell 167 (5), 1398-1414. e24, 2016 | 647 | 2016 |
β-Glucan reverses the epigenetic state of LPS-induced immunological tolerance B Novakovic, E Habibi, SY Wang, RJW Arts, R Davar, W Megchelenbrink, ... Cell 167 (5), 1354-1368. e14, 2016 | 544 | 2016 |
Active transcription and essential role of RNA polymerase II at the centromere during mitosis FL Chan, OJ Marshall, R Saffery, B Won Kim, E Earle, KHA Choo, ... Proceedings of the National Academy of Sciences 109 (6), 1979-1984, 2012 | 287 | 2012 |
The architecture and evolution of cancer neochromosomes DW Garsed, OJ Marshall, VDA Corbin, A Hsu, L Di Stefano, J Schröder, ... Cancer cell 26 (5), 653-667, 2014 | 187 | 2014 |
Assisted reproductive technologies are associated with limited epigenetic variation at birth that largely resolves by adulthood B Novakovic, S Lewis, J Halliday, J Kennedy, DP Burgner, A Czajko, ... Nature Communications 10 (1), 3922, 2019 | 111 | 2019 |
The hematopoietic transcription factors RUNX1 and ERG prevent AML1-ETO oncogene overexpression and onset of the apoptosis program in t (8; 21) AMLs A Mandoli, AA Singh, KHM Prange, E Tijchon, M Oerlemans, R Dirks, ... Cell reports 17 (8), 2087-2100, 2016 | 67 | 2016 |
Chromatin-based classification of genetically heterogeneous AMLs into two distinct subtypes with diverse stemness phenotypes G Yi, ATJ Wierenga, F Petraglia, P Narang, EM Janssen-Megens, ... Cell reports 26 (4), 1059-1069. e6, 2019 | 37 | 2019 |
Neonatal BCG vaccination is associated with a long-term DNA methylation signature in circulating monocytes S Bannister, B Kim, J Domínguez-Andrés, G Kilic, BRE Ansell, ... Science Advances 8 (31), eabn4002, 2022 | 32 | 2022 |
Gender-affirming hormone therapy induces specific DNA methylation changes in blood R Shepherd, I Bretherton, K Pang, T Mansell, A Czajko, B Kim, A Vlahos, ... Clinical Epigenetics 14 (1), 24, 2022 | 24 | 2022 |
The acute myeloid leukemia associated AML1-ETO fusion protein alters the transcriptome and cellular progression in a single-oncogene expressing in vitro induced pluripotent … E Tijchon, G Yi, A Mandoli, JGA Smits, F Ferrari, BMH Heuts, F Wijnen, ... PLoS One 14 (12), e0226435, 2019 | 16 | 2019 |
Multi-omics profiling reveals a distinctive epigenome signature for high-risk acute promyelocytic leukemia AA Singh, F Petraglia, A Nebbioso, G Yi, M Conte, S Valente, A Mandoli, ... Oncotarget 9 (39), 25647, 2018 | 15 | 2018 |
C-terminal BRE overexpression in 11q23-rearranged and t (8; 16) acute myeloid leukemia is caused by intragenic transcription initiation AE Marneth, KHM Prange, ASA Al Hinai, SM Bergevoet, N Tesi, ... Leukemia 32 (3), 828-836, 2018 | 7 | 2018 |
CBFβ-MYH11 interferes with megakaryocyte differentiation via modulating a gene program that includes GATA2 and KLF1 G Yi, A Mandoli, L Jussen, E Tijchon, MGJM van Bergen, G Cordonnier, ... Blood Cancer Journal 9 (3), 33, 2019 | 6 | 2019 |
Assisted reproductive technologies are associated with limited epige‑netic variation at birth that largely resolves by adulthood. Nat Commun. 2019 B Novakovic, S Lewis, J Halliday, J Kennedy, DP Burgner, A Czajko, ... | 5 | 2019 |
Combined HAT/EZH2 modulation leads to cancer-selective cell death F Petraglia, AA Singh, V Carafa, A Nebbioso, M Conte, L Scisciola, ... Oncotarget 9 (39), 25630, 2018 | 5 | 2018 |
Triiodothyronine (T3) induces limited transcriptional and DNA methylation reprogramming in human monocytes R Shepherd, B Kim, R Saffery, B Novakovic Biomedicines 10 (3), 608, 2022 | 2 | 2022 |
Transcriptomic Remodelling of Fetal Endothelial Cells During Establishment of Inflammatory Memory E Weiss, A Vlahos, B Kim, S Wijegunasekara, D Shanmuganathan, ... Frontiers in Immunology 12, 757393, 2021 | 2 | 2021 |
Impact of Distinct Anti-Androgen Exposures on the Plasma Metabolome in Feminizing Gender-Affirming Hormone Therapy R Shepherd, LM Angus, T Mansell, B Arman, BW Kim, K Lange, ... The Journal of Clinical Endocrinology & Metabolism, dgae226, 2024 | | 2024 |