Bas Brouwers
Bas Brouwers
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Impaired islet function in commonly used transgenic mouse lines due to human growth hormone minigene expression
B Brouwers, G de Faudeur, AB Osipovich, L Goyvaerts, K Lemaire, ...
Cell metabolism 20 (6), 979-990, 2014
Human gain-of-function MC4R variants show signaling bias and protect against obesity
LA Lotta, J Mokrosiński, EM de Oliveira, C Li, SJ Sharp, J Luan, ...
Cell 177 (3), 597-607. e9, 2019
Metabolic and behavioural phenotypes in Nestin-Cre mice are caused by hypothalamic expression of human growth hormone
J Declercq, B Brouwers, VPEG Pruniau, P Stijnen, G de Faudeur, K Tuand, ...
PloS one 10 (8), e0135502, 2015
Phlorizin pretreatment reduces acute renal toxicity in a mouse model for diabetic nephropathy
B Brouwers, VPEG Pruniau, EJG Cauwelier, F Schuit, E Lerut, N Ectors, ...
Journal of Biological Chemistry 288 (38), 27200-27207, 2013
The AlfpCre mouse revisited, evidence for liver steatosis related to growth hormone deficiency
V Pruniau, E Louagie, B Brouwers, J Declercq, J Creemers
Hepatology 58 (6), 2209-2210, 2013
Endoplasmic reticulum-associated degradation of the mouse PC1/3-N222D hypomorph and human PCSK1 mutations contributes to obesity
P Stijnen, B Brouwers, E Dirkx, B Ramos-Molina, L Van Lommel, F Schuit, ...
International journal of obesity 40 (6), 973-981, 2016
Liver-specific inactivation of the proprotein convertase FURIN leads to increased hepatocellular carcinoma growth
J Declercq, B Brouwers, VPEG Pruniau, P Stijnen, K Tuand, S Meulemans, ...
BioMed research international 2015, 2015
Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis
P Kirwan, RG Kay, B Brouwers, V Herranz-Pérez, M Jura, P Larraufie, ...
Molecular metabolism 17, 82-97, 2018
Unexpected Phenotypes in Mouse Models Carrying the Human Growth Hormone Minigene to Enhance Transgene Expression
B Brouwers, JWM Creemers, J Declercq
Journal of Steroids & Hormonal Science 6 (2), 2, 2015
Endosome to trans-Golgi network transport of Proprotein Convertase 7 is mediated by a cluster of basic amino acids and palmitoylated cysteines
J Declercq, B Ramos-Molina, R Sannerud, B Brouwers, VPEG Pruniau, ...
European journal of cell biology 96 (5), 432-439, 2017
Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities
T Sonoyama, LKJ Stadler, M Zhu, JM Keogh, E Henning, F Hisama, ...
Scientific reports 10 (1), 1-14, 2020
Loss of Furin in β-Cells Induces an mTORC1-ATF4 anabolic pathway that leads to β-cell dysfunction
B Brouwers, I Coppola, K Vints, B Dislich, N Jouvet, L Van Lommel, ...
Diabetes 70 (2), 492-503, 2021
Human Growth Hormone in Transgenesis: A Growing Problem?
B Brouwers, JWM Creemers
Diabetes 64 (11), 3648-3650, 2015
Transgenic artifacts caused by passenger human growth hormone
G de Faudeur, B Brouwers, F Schuit, JWM Creemers, B Ramos-Molina
Trends in Endocrinology & Metabolism 29 (10), 670-674, 2018
Furin controls β cell function via mTORC1 signaling
B Brouwers, I Coppola, K Vints, B Dislich, N Jouvet, L Van Lommel, ...
bioRxiv, 2020
Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation
B Brouwers, EM de Oliveira, M Marti-Solano, FBF Monteiro, SA Laurin, ...
Cell reports 34 (12), 108862, 2021
Differential Effects of Furin Deficiency on Insulin Receptor Processing and Glucose Control in Liver and Pancreatic β Cells of Mice
I Coppola, B Brouwers, S Meulemans, B Ramos-Molina, JWM Creemers
International Journal of Molecular Sciences 22 (12), 6344, 2021
Human POMC processing in vitro and in vivo revealed by quantitative peptidomics
P Kirwan, R Kay, B Brouwers, V Herranz-Perez, M Jura, P Larraufie, ...
bioRxiv, 257121, 2018
Furin in beta cell function
B Brouwers
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Artikelen 1–19