Sebastian Bartsch
Sebastian Bartsch
c-LEcta GmbH
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Complete inversion of enantioselectivity towards acetylated tertiary alcohols by a double mutant of a Bacillus subtilis esterase
S Bartsch, R Kourist, UT Bornscheuer
Angewandte Chemie International Edition 47 (8), 1508-1511, 2008
The α/β-hydrolase fold 3DM database (ABHDB) as a tool for protein engineering
R Kourist, H Jochens, S Bartsch, R Kuipers, SK Padhi, M Gall, D Böttcher, ...
From existing data to novel hypotheses, 175, 2010
Priming ammonia lyases and aminomutases for industrial and therapeutic applications
MM Heberling, B Wu, S Bartsch, DB Janssen
Current opinion in chemical biology 17 (2), 250-260, 2013
Understanding Promiscuous Amidase Activity of an Esterase from Bacillus subtilis
R Kourist, S Bartsch, L Fransson, K Hult, UT Bornscheuer
ChemBioChem 9 (1), 67-69, 2008
Highly enantioselective synthesis of arylaliphatic tertiary alcohols using mutants of an esterase from Bacillus subtilis
R Kourist, S Bartsch, UT Bornscheuer
Advanced Synthesis & Catalysis 349 (8‐9), 1393-1398, 2007
Mutational analysis of phenylalanine ammonia lyase to improve reactions rates for various substrates
S Bartsch, UT Bornscheuer
Protein Engineering, Design & Selection 23 (12), 929-933, 2010
A single residue influences the reaction mechanism of ammonia lyases and mutases
S Bartsch, UT Bornscheuer
Angewandte Chemie International Edition 48 (18), 3362-3365, 2009
Mechanism‐Inspired Engineering of Phenylalanine Aminomutase for Enhanced β‐Regioselective Asymmetric Amination of Cinnamates
B Wu, W Szymański, GG Wybenga, MM Heberling, S Bartsch, ...
Angewandte Chemie 124 (2), 497-501, 2012
The crystal structure of an esterase from the hyperthermophilic microorganism Pyrobaculum calidifontis VA1 explains its enantioselectivity
GJ Palm, E Fernández-Álvaro, X Bogdanović, S Bartsch, J Sczodrok, ...
Applied microbiology and biotechnology 91 (4), 1061-1072, 2011
Vollständige Umkehrung der Enantioselektivität gegen acetylierte tertiäre Alkohole durch eine Doppelmutation in einer Esterase aus Bacillus subtilis
S Bartsch, R Kourist, UT Bornscheuer
Angewandte Chemie 120 (8), 1531-1534, 2008
Redesign of a phenylalanine aminomutase into a phenylalanine ammonia lyase
S Bartsch, GG Wybenga, M Jansen, MM Heberling, B Wu, BW Dijkstra, ...
ChemCatChem 5 (7), 1797-1802, 2013
Biochemical properties and crystal structure of a β-phenylalanine aminotransferase from Variovorax paradoxus
CG Crismaru, GG Wybenga, W Szymanski, HJ Wijma, B Wu, S Bartsch, ...
Applied and environmental microbiology 79 (1), 185-195, 2013
Explaining operational instability of amine transaminases: substrate-induced inactivation mechanism and influence of quaternary structure on enzyme–cofactor intermediate stability
T Börner, S Rämisch, ER Reddem, S Bartsch, A Vogel, ...
Acs Catalysis 7 (2), 1259-1269, 2017
Three in one: temperature, solvent and catalytic stability by engineering the cofactor‐binding element of amine transaminase
T Börner, S Rämisch, S Bartsch, A Vogel, P Adlercreutz, C Grey
ChemBioChem 18 (15), 1482-1486, 2017
Probing the enantioselectivity of Bacillus subtilis esterase BS2 for tert. alcohols
M Wiggers, J Holt, R Kourist, S Bartsch, IWCE Arends, AJ Minnaard, ...
Journal of Molecular Catalysis B: Enzymatic 60 (1-2), 82-86, 2009
Enzymatic network for production of ether amines from alcohols
CM Palacio, CG Crismaru, S Bartsch, V Navickas, K Ditrich, M Breuer, ...
Biotechnology and bioengineering 113 (9), 1853-1861, 2016
Ironing out their differences: dissecting the structural determinants of a phenylalanine aminomutase and ammonia lyase
MM Heberling, MF Masman, S Bartsch, GG Wybenga, BW Dijkstra, ...
ACS chemical biology 10 (4), 989-997, 2015
Einfluss einer einzelnen Aminosäure auf den Reaktionsmechanismus von Ammonium‐Lyasen und‐Mutasen
S Bartsch, UT Bornscheuer
Angewandte Chemie 121 (18), 3412-3415, 2009
Science of Synthesis: Biocatalysis in Organic Synthesis Vol. 2
L Aitao, S Au, S Bartsch, D Beecher, A Boffi
Georg Thieme Verlag, 2015
Synthesis of Sebacic Acid Using a De Novo Designed Retro‐Aldolase as a Key Catalyst
KB Otte, E Maurer, M Kirtz, D Grabs, E Althoff, S Bartsch, A Vogel, ...
ChemCatChem 9 (8), 1378-1382, 2017
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