| Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos E Zuo, Y Sun, W Wei, T Yuan, W Ying, H Sun, L Yuan, LM Steinmetz, Y Li, ... Science 364 (6437), 289-292, 2019 | 718 | 2019 |
| Structural specializations of α4β7, an integrin that mediates rolling adhesion Y Yu, J Zhu, LZ Mi, T Walz, H Sun, JF Chen, TA Springer Journal of Cell Biology 196 (1), 131-146, 2012 | 128 | 2012 |
| Distinct chemokine signaling regulates integrin ligand specificity to dictate tissue-specific lymphocyte homing H Sun, J Liu, YJ Zheng, YD Pan, K Zhang, JF Chen Developmental cell 30 (1), 61-70, 2014 | 87 | 2014 |
| High-affinity bent β2-integrin molecules in arresting neutrophils face each other through binding to ICAMs in cis Z Fan, WB Kiosses, H Sun, M Orecchioni, Y Ghosheh, DM Zajonc, ... Cell reports 26 (1), 119-130. e5, 2019 | 60 | 2019 |
| Talin-1 is the principal platelet Rap1 effector of integrin activation F Lagarrigue, DS Paul, AR Gingras, AJ Valadez, H Sun, J Lin, MN Cuevas, ... Blood, The Journal of the American Society of Hematology 136 (10), 1180-1190, 2020 | 56 | 2020 |
| Bile acids evoke placental inflammation by activating Gpbar1/NF-κB pathway in intrahepatic cholestasis of pregnancy YH Zhang, YD Pan, CD Lin, YJ Zheng, H Sun, HL Zhang, JL Wang, ... Journal of Molecular Cell Biology 8 (6), 530-541, 2016 | 45 | 2016 |
| Regulatory T-cell depletion in the gut caused by integrin β7 deficiency exacerbates DSS colitis by evoking aberrant innate immunity HL Zhang, YJ Zheng, YD Pan, C Xie, H Sun, YH Zhang, MY Yuan, ... Mucosal immunology 9 (2), 391-400, 2016 | 45 | 2016 |
| Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation MA Lopez-Ramirez, CC Lai, SI Soliman, P Hale, A Pham, EJ Estrada, ... The Journal of clinical investigation 131 (13), 2021 | 37 | 2021 |
| Kindlin-3 recruitment to the plasma membrane precedes high affinity β2 integrin and neutrophil arrest from rolling L Wen, A Marki, P Roy, S McArdle, H Sun, Z Fan, AR Gingras, ... Blood, 2020 | 37 | 2020 |
| Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation F Lagarrigue, AR Gingras, DS Paul, AJ Valadez, MN Cuevas, H Sun, ... Blood advances 2 (18), 2358-2368, 2018 | 34 | 2018 |
| Distinct integrin activation pathways for effector and regulatory T cell trafficking and function H Sun, F Lagarrigue, H Wang, Z Fan, MA Lopez-Ramirez, JT Chang, ... Journal of Experimental Medicine 218 (2), 2021 | 32 | 2021 |
| Integrin α4β7 switches its ligand specificity via distinct conformer-specific activation SH Wang, CY Wu, YB Zhang, QL Zhong, H Sun, WP Cao, GX Ge, GH Li, ... Journal of Cell Biology 217 (8), 2799-2812, 2018 | 28 | 2018 |
| The activation and regulation of β2 integrins in phagocytes and phagocytosis H Sun, K Zhi, L Hu, Z Fan Frontiers in Immunology 12, 633639, 2021 | 27 | 2021 |
| GOTI, a method to identify genome-wide off-target effects of genome editing in mouse embryos E Zuo, Y Sun, W Wei, T Yuan, W Ying, H Sun, L Yuan, LM Steinmetz, Y Li, ... Nature protocols 15 (9), 3009-3029, 2020 | 26 | 2020 |
| β7 integrin inhibition can increase intestinal inflammation by impairing homing of CD25hiFoxP3+ regulatory T cells H Sun, W Kuk, J Rivera-Nieves, MA Lopez-Ramirez, L Eckmann, ... Cellular and molecular gastroenterology and hepatology 9 (3), 369-385, 2020 | 26 | 2020 |
| Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development H Sun, F Lagarrigue, AR Gingras, Z Fan, K Ley, MH Ginsberg Journal of Cell Biology 217 (4), 1453-1465, 2018 | 25 | 2018 |
| The CC′ and DE loops in Ig domains 1 and 2 of MAdCAM-1 play different roles in MAdCAM-1 binding to low-and high-affinity integrin α4β7 H Sun, YM Wu, JP Qi, YD Pan, G Ge, JF Chen Journal of Biological Chemistry 286 (14), 12086-12092, 2011 | 18 | 2011 |
| Frontline Science: A flexible kink in the transmembrane domain impairs β2 integrin extension and cell arrest from rolling H Sun, Z Fan, AR Gingras, MA Lopez-Ramirez, MH Ginsberg, K Ley Journal of leukocyte biology 107 (2), 175-183, 2020 | 17 | 2020 |
| Neuroinflammation plays a critical role in cerebral cavernous malformation disease CC Lai, B Nelsen, E Frias-Anaya, H Gallego-Gutierrez, M Orecchioni, ... Circulation research 131 (11), 909-925, 2022 | 16 | 2022 |
| Roles of mitochondria in neutrophils Z Cao, M Zhao, H Sun, L Hu, Y Chen, Z Fan Frontiers in immunology 13, 934444, 2022 | 16 | 2022 |
Zhichao FanDepartment of Immunology, University of Connecticut Health CenterGeverifieerd e-mailadres voor uchc.edu
