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Paraskevi Giannakakou
Paraskevi Giannakakou
Professor of pharmacology in Medicine, Weill Cornell
Geverifieerd e-mailadres voor med.cornell.edu
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Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation
H Zhang, D Freitas, HS Kim, K Fabijanic, Z Li, H Chen, MT Mark, H Molina, ...
Nature cell biology 20 (3), 332-343, 2018
13522018
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
NJ Mabjeesh, D Escuin, TM LaVallee, VS Pribluda, GM Swartz, ...
Cancer cell 3 (4), 363-375, 2003
9172003
Paclitaxel-resistant human ovarian cancer cells have mutant β-tubulins that exhibit impaired paclitaxel-driven polymerization
P Giannakakou, DL Sackett, YK Kang, Z Zhan, JTM Buters, T Fojo, ...
Journal of Biological Chemistry 272 (27), 17118-17125, 1997
9171997
Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol®)
RJ Kowalski, P Giannakakou, E Hamel
Journal of Biological Chemistry 272 (4), 2534-2541, 1997
7181997
Synthesis of epothilones A and B in solid and solution phase
KC Nicolaou, N Winssinger, J Pastor, S Ninkovic, F Sarabia, Y He, ...
Nature 387 (6630), 268-272, 1997
6321997
A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells
P Giannakakou, R Gussio, E Nogales, KH Downing, D Zaharevitz, ...
Proceedings of the National Academy of Sciences 97 (6), 2904-2909, 2000
6262000
Targeting microtubules for cancer chemotherapy
J Zhou, P Giannakakou
Current Medicinal Chemistry-Anti-Cancer Agents 5 (1), 65-71, 2005
6192005
Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death
MV Blagosklonny, P Giannakakou, WS El-Deiry, DGI Kingston, PI Higgs, ...
Cancer research 57 (1), 130-135, 1997
5221997
Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways
TH Wang, HS Wang, H Ichijo, P Giannakakou, JS Foster, T Fojo, ...
Journal of Biological Chemistry 273 (9), 4928-4936, 1998
5071998
Taxane-induced blockade to nuclear accumulation of the androgen receptor predicts clinical responses in metastatic prostate cancer
MS Darshan, MS Loftus, M Thadani-Mulero, BP Levy, D Escuin, XK Zhou, ...
Cancer research 71 (18), 6019-6029, 2011
4832011
Capture of circulating tumor cells from whole blood of prostate cancer patients using geometrically enhanced differential immunocapture (GEDI) and a prostate-specific antibody
JP Gleghorn, ED Pratt, D Denning, H Liu, NH Bander, ST Tagawa, ...
Lab on a Chip 10 (1), 27-29, 2010
4692010
p53 is associated with cellular microtubules and is transported to the nucleus by dynein
P Giannakakou, DL Sackett, Y Ward, KR Webster, MV Blagosklonny, ...
Nature cell biology 2 (10), 709-717, 2000
4622000
The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more …
RJ Kowalski, P Giannakakou, SP Gunasekera, RE Longley, BW Day, ...
Molecular pharmacology 52 (4), 613-622, 1997
3431997
The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for …
DE Pryor, A O'Brate, G Bilcer, JF Díaz, Y Wang, Y Wang, M Kabaki, ...
Biochemistry 41 (29), 9109-9115, 2002
3122002
Prospective multicenter validation of androgen receptor splice variant 7 and hormone therapy resistance in high-risk castration-resistant prostate cancer: the PROPHECY study
AJ Armstrong, S Halabi, J Luo, DM Nanus, P Giannakakou, ...
Journal of Clinical Oncology 37 (13), 1120, 2019
3072019
Low concentrations of paclitaxel induce cell type-dependent p53, p21 and G1/G2 arrest instead of mitotic arrest: molecular determinants of paclitaxel-induced cytotoxicity
P Giannakakou, R Robey, T Fojo, MV Blagosklonny
Oncogene 20 (29), 3806-3813, 2001
3042001
The importance of p53 location: nuclear or cytoplasmic zip code?
A O’Brate, P Giannakakou
Drug resistance updates 6 (6), 313-322, 2003
2972003
Functional characterization of circulating tumor cells with a prostate-cancer-specific microfluidic device
BJ Kirby, M Jodari, MS Loftus, G Gakhar, ED Pratt, C Chanel-Vos, ...
PloS one 7 (4), e35976, 2012
2922012
Androgen receptor splice variants determine taxane sensitivity in prostate cancer
M Thadani-Mulero, L Portella, S Sun, M Sung, A Matov, RL Vessella, ...
Cancer research 74 (8), 2270-2282, 2014
2672014
A SIRT2-selective inhibitor promotes c-Myc oncoprotein degradation and exhibits broad anticancer activity
H Jing, J Hu, B He, YLN Abril, J Stupinski, K Weiser, M Carbonaro, ...
Cancer cell 29 (3), 297-310, 2016
2632016
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Artikelen 1–20