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Bart de Laat
Bart de Laat
Assistant Professor Adjunct, Yale University
Adresse e-mail validée de yale.edu
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PET imaging reveals lower kappa opioid receptor availability in alcoholics but no effect of age
A Vijay, D Cavallo, A Goldberg, B de Laat, N Nabulsi, Y Huang, ...
Neuropsychopharmacology 43 (13), 2539-2547, 2018
402018
The effect of isoflurane on 18F-FDG uptake in the rat brain: a fully conscious dynamic PET study using motion compensation
MG Spangler-Bickell, B de Laat, R Fulton, G Bormans, J Nuyts
EJNMMI research 6, 1-10, 2016
402016
Cerebral dopaminergic and glutamatergic transmission relate to different subjective responses of acute alcohol intake: an in vivo multimodal imaging study
G Leurquin‐Sterk, J Ceccarini, CL Crunelle, A Weerasekera, B de Laat, ...
Addiction biology 23 (3), 931-944, 2018
392018
Lower limbic metabotropic glutamate receptor 5 availability in alcohol dependence
G Leurquin-Sterk, J Ceccarini, CL Crunelle, B de Laat, J Verbeek, ...
Journal of Nuclear Medicine 59 (4), 682-690, 2018
322018
The kappa opioid receptor is associated with naltrexone-induced reduction of drinking and craving
B de Laat, A Goldberg, J Shi, JM Tetrault, N Nabulsi, MQ Zheng, ...
Biological psychiatry 86 (11), 864-871, 2019
302019
Recovery of decreased metabotropic glutamate receptor 5 availability in abstinent alcohol-dependent patients
J Ceccarini, G Leurquin-Sterk, CL Crunelle, B de Laat, G Bormans, ...
Journal of Nuclear Medicine 61 (2), 256-262, 2020
292020
Quantification of TSPO overexpression in a rat model of local neuroinflammation induced by intracerebral injection of LPS by the use of [18F]DPA-714 PET
D Ory, A Postnov, M Koole, S Celen, B de Laat, A Verbruggen, ...
European journal of nuclear medicine and molecular imaging 43, 163-172, 2016
272016
Kinetic modeling and long‐term test‐retest reproducibility of the mGluR5 PET tracer 18F‐FPEB in human brain
G Leurquin‐Sterk, A Postnov, B De Laat, C Casteels, S Celen, ...
Synapse 70 (4), 153-162, 2016
252016
Preclinical evaluation and quantification of 18F-FPEB as a radioligand for PET imaging of the metabotropic glutamate receptor 5
B de Laat, G Leurquin-Sterk, S Celen, G Bormans, M Koole, K Van Laere, ...
Journal of Nuclear Medicine 56 (12), 1954-1959, 2015
242015
Evaluation of snake envenomation-induced renal dysfunction in dogs using early urinary biomarkers of nephrotoxicity
A Hrovat, JP Schoeman, B de Laat, E Meyer, P Smets, A Goddard, ...
The Veterinary Journal 198 (1), 239-244, 2013
242013
Effects of alcohol exposure on the glutamatergic system: a combined longitudinal 18F‐FPEB and 1H‐MRS study in rats
B de Laat, A Weerasekera, G Leurquin‐Sterk, W Gsell, G Bormans, ...
Addiction Biology 24 (4), 696-706, 2019
232019
Glutamatergic biomarkers for cocaine addiction: a longitudinal study using MR spectroscopy and mGluR5 PET in self-administering rats
B de Laat, A Weerasekera, G Leurquin-Sterk, G Bormans, U Himmelreich, ...
Journal of Nuclear Medicine 59 (6), 952-959, 2018
232018
Positive association between limbic metabotropic glutamate receptor 5 availability and novelty-seeking temperament in humans: an 18F-FPEB PET study
G Leurquin-Sterk, J Van den Stock, CL Crunelle, B de Laat, ...
Journal of Nuclear Medicine 57 (11), 1746-1752, 2016
232016
Occupancy of the kappa opioid receptor by naltrexone predicts reduction in drinking and craving
B de Laat, N Nabulsi, Y Huang, SS O’Malley, JC Froehlich, ED Morris, ...
Molecular Psychiatry 26 (9), 5053-5060, 2021
202021
Optimising rigid motion compensation for small animal brain PET imaging
MG Spangler-Bickell, L Zhou, AZ Kyme, B De Laat, RR Fulton, J Nuyts
Physics in Medicine & Biology 61 (19), 7074, 2016
182016
Alcohol addiction is associated with decreased limbic mGluR5 availability: a 18F-FPEB PET study in human.
G Leurquin-Sterk, C Crunelle, J Ceccarini, B de Laat, H Peuskens, ...
Journal of Nuclear Medicine 57 (supplement 2), 15-15, 2016
82016
Glutamatergic biomarkers for cocaine addiction: a longitudinal study in self-administering rats using MRS and mGluR5 PET
B de Laat, A Weerasekera, G Leurquin-Sterk, GM Bormans, ...
Journal of Nuclear Medicine, 2018
52018
A local-neighborhood Lassen plot filter for creating occupancy and non-displaceable binding images
B de Laat, ED Morris
Journal of Cerebral Blood Flow & Metabolism 41 (6), 1379-1389, 2021
42021
Recovery of decreased metabotropic glutamate receptor 5 availability in abstinent alcohol-dependent subjects
J Ceccarini, G Leurquin-Sterk, C Crunelle, B De Laat, G Bormans, ...
Journal of Nuclear Medicine 58 (supplement 1), 14-14, 2017
42017
EC50 images, a novel endpoint from PET target occupancy studies, reveal spatial variation in apparent drug affinity
B De Laat, J Hoye, H Liu, ED Morris
European Journal of Nuclear Medicine and Molecular Imaging, 1-10, 2022
32022
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