Lea Starita
Lea Starita
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Network modeling links breast cancer susceptibility and centrosome dysfunction
MA Pujana, JDJ Han, LM Starita, KN Stevens, M Tewari, JS Ahn, ...
Nature genetics 39 (11), 1338-1349, 2007
6532007
Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation
DL Swaney, P Beltrao, L Starita, A Guo, J Rush, S Fields, NJ Krogan, ...
Nature methods 10 (7), 676-682, 2013
4062013
BRCA1-dependent ubiquitination of γ-tubulin regulates centrosome number
LM Starita, Y Machida, S Sankaran, JE Elias, K Griffin, BP Schlegel, ...
Molecular and cellular biology 24 (19), 8457-8466, 2004
3492004
The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair
LM Starita, JD Parvin
Current opinion in cell biology 15 (3), 345-350, 2003
2772003
Accurate classification of BRCA1 variants with saturation genome editing
GM Findlay, RM Daza, B Martin, MD Zhang, AP Leith, M Gasperini, ...
Nature 562 (7726), 217-222, 2018
2392018
Massively parallel functional analysis of BRCA1 RING domain variants
LM Starita, DL Young, M Islam, JO Kitzman, J Gullingsrud, RJ Hause, ...
Genetics 200 (2), 413-422, 2015
2142015
BRCA1/BARD1 Ubiquitinate Phosphorylated RNA Polymerase II
LM Starita, AA Horwitz, MC Keogh, C Ishioka, JD Parvin, N Chiba
Journal of Biological Chemistry 280 (26), 24498-24505, 2005
1552005
Variant interpretation: functional assays to the rescue
LM Starita, N Ahituv, MJ Dunham, JO Kitzman, FP Roth, G Seelig, ...
The American Journal of Human Genetics 101 (3), 315-325, 2017
1472017
Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination
S Sankaran, LM Starita, AC Groen, MJ Ko, JD Parvin
Molecular and cellular biology 25 (19), 8656-8668, 2005
1312005
Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis
LM Starita, JN Pruneda, RS Lo, DM Fowler, HJ Kim, JB Hiatt, J Shendure, ...
Proceedings of the National Academy of Sciences 110 (14), E1263-E1272, 2013
1242013
Multiplex assessment of protein variant abundance by massively parallel sequencing
KA Matreyek, LM Starita, JJ Stephany, B Martin, MA Chiasson, VE Gray, ...
Nature genetics 50 (6), 874-882, 2018
1232018
Massively parallel single-amino-acid mutagenesis
JO Kitzman, LM Starita, RS Lo, S Fields, J Shendure
Nature methods 12 (3), 203-206, 2015
1112015
Overexpression of a protein fragment of RNA helicase A causes inhibition of endogenous BRCA1 function and defects in ploidy and cytokinesis in mammary epithelial cells
BP Schlegel, LM Starita, JD Parvin
Oncogene 22 (7), 983-991, 2003
1062003
Mutations in elongation factor 1β, a guanine nucleotide exchange factor, enhance translational fidelity
A Carr-Schmid, L Valente, VI Loik, T Williams, LM Starita, TG Kinzy
Molecular and Cellular Biology 19 (8), 5257-5266, 1999
871999
Identification of domains of BRCA1 critical for the ubiquitin-dependent inhibition of centrosome function
S Sankaran, LM Starita, AM Simons, JD Parvin
Cancer research 66 (8), 4100-4107, 2006
782006
The power of multiplexed functional analysis of genetic variants
M Gasperini, L Starita, J Shendure
Nature protocols 11 (10), 1782-1787, 2016
762016
On the design of CRISPR-based single-cell molecular screens
AJ Hill, JL McFaline-Figueroa, LM Starita, MJ Gasperini, KA Matreyek, ...
Nature methods 15 (4), 271, 2018
732018
Bedside back to bench: building bridges between basic and clinical genomic research
TA Manolio, DM Fowler, LM Starita, MA Haendel, DG MacArthur, ...
Cell 169 (1), 6-12, 2017
732017
Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California
X Deng, W Gu, S Federman, L du Plessis, OG Pybus, N Faria, C Wang, ...
Science, 2020
672020
BRCA1 DNA-binding activity is stimulated by BARD1
AM Simons, AA Horwitz, LM Starita, K Griffin, RS Williams, JNM Glover, ...
Cancer research 66 (4), 2012-2018, 2006
662006
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Artikelen 1–20