| Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain N Sever, T Yang, MS Brown, JL Goldstein, RA DeBose-Boyd Molecular cell 11 (1), 25-33, 2003 | 466 | 2003 |
| Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase BL Song, N Sever, RA DeBose-Boyd Molecular cell 19 (6), 829-840, 2005 | 423 | 2005 |
| Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol N Sever, BL Song, D Yabe, JL Goldstein, MS Brown, RA DeBose-Boyd Journal of Biological Chemistry 278 (52), 52479-52490, 2003 | 374 | 2003 |
| Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells JR Dwyer, N Sever, M Carlson, SF Nelson, PA Beachy, F Parhami Journal of Biological Chemistry 282 (12), 8959-8968, 2007 | 372 | 2007 |
| Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein JRPM Strating, L van der Linden, L Albulescu, J Bigay, M Arita, L Delang, ... Cell reports 10 (4), 600-615, 2015 | 240 | 2015 |
| Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response BR Myers, N Sever, YC Chong, J Kim, JD Belani, S Rychnovsky, ... Developmental cell 26 (4), 346-357, 2013 | 200 | 2013 |
| Genetic and biochemical definition of the Hedgehog receptor X Zheng, RK Mann, N Sever, PA Beachy Genes & development 24 (1), 57-71, 2010 | 151 | 2010 |
| Cilia-associated oxysterols activate smoothened DR Raleigh, N Sever, PK Choksi, MA Sigg, KM Hines, BM Thompson, ... Molecular cell 72 (2), 316-327. e5, 2018 | 110 | 2018 |
| Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2 PCW Lee, N Sever, RA DeBose-Boyd Journal of Biological Chemistry 280 (26), 25242-25249, 2005 | 96 | 2005 |
| Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase N Sever, PCW Lee, BL Song, RB Rawson, RA DeBose-Boyd Journal of Biological Chemistry 279 (41), 43136-43147, 2004 | 67 | 2004 |
| Endogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols N Sever, RK Mann, L Xu, WJ Snell, CI Hernandez-Lara, NA Porter, ... Proceedings of the National Academy of Sciences 113 (21), 5904-5909, 2016 | 66 | 2016 |
| Mechanism of lamellar body formation by lung surfactant protein B N Sever, G Miličić, NO Bodnar, X Wu, TA Rapoport Molecular cell 81 (1), 49-66. e8, 2021 | 26 | 2021 |
| Simultaneous measurement of smoothened entry into and exit from the primary cilium J Kim, EYC Hsia, J Kim, N Sever, PA Beachy, X Zheng PLoS One 9 (8), e104070, 2014 | 19 | 2014 |
| Sterol regulation of developmental and oncogenic Hedgehog signaling V Daggubati, DR Raleigh, N Sever Biochemical pharmacology 196, 114647, 2022 | 14 | 2022 |
| S6K2 promises an important therapeutic potential for cancer Nİ Sever, S Cengiz Şahin Future Oncology 15 (1), 95-102, 2019 | 6 | 2019 |
| Oxysterols are novel activators of hedgehog and Wnt signaling. CM Amantea, JA Dwyer, N Sever, PA Beachy, W Kim, TJ Hahn, S Tetradis, ... JOURNAL OF BONE AND MINERAL RESEARCH 21, S157-S157, 2006 | 5 | 2006 |
| Methods and compositions for treating a respiratory disease TA Rapoport, NO Bodnar, G Milicic, N Sever US Patent App. 17/232,891, 2021 | | 2021 |
| Identification of the phosphatase for S6K2 may sensitize breast cancer cells to apoptosis NI Sever, SC Sahin, BK Yardimci Febs Open Bio, 2021 | | 2021 |
| Investigation of microRNAs which regulate S6K2 may enlighten new paths for breast cancer therapy Nİ Sever, S Cengiz Şahin FEBS OPEN BIO, 2019 | | 2019 |
| Characterization of the ubiquitin ligase for S6K2 may overcome apoptotic barrier for breast and lung cancer cells N Sever, S Cengiz Şahin FEBS OPEN BIO, 2018 | | 2018 |
