Navdar Sever
Navdar Sever
Howard Hughes Medical Institute
Verified email at hms.harvard.edu
Title
Cited by
Cited by
Year
Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain
N Sever, T Yang, MS Brown, JL Goldstein, RA DeBose-Boyd
Molecular cell 11 (1), 25-33, 2003
3812003
Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase
BL Song, N Sever, RA DeBose-Boyd
Molecular cell 19 (6), 829-840, 2005
3242005
Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol
N Sever, BL Song, D Yabe, JL Goldstein, MS Brown, RA DeBose-Boyd
Journal of Biological Chemistry 278 (52), 52479-52490, 2003
3192003
Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells
JR Dwyer, N Sever, M Carlson, SF Nelson, PA Beachy, F Parhami
Journal of Biological Chemistry 282 (12), 8959-8968, 2007
3042007
Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein
JRPM Strating, L van der Linden, L Albulescu, J Bigay, M Arita, L Delang, ...
Cell reports 10 (4), 600-615, 2015
1552015
Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response
BR Myers, N Sever, YC Chong, J Kim, JD Belani, S Rychnovsky, ...
Developmental cell 26 (4), 346-357, 2013
1512013
Genetic and biochemical definition of the Hedgehog receptor
X Zheng, RK Mann, N Sever, PA Beachy
Genes & development 24 (1), 57-71, 2010
1182010
Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2
PCW Lee, N Sever, RA DeBose-Boyd
Journal of Biological Chemistry 280 (26), 25242-25249, 2005
802005
Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
N Sever, PCW Lee, BL Song, RB Rawson, RA DeBose-Boyd
Journal of Biological Chemistry 279 (41), 43136-43147, 2004
602004
Cilia-associated oxysterols activate smoothened
DR Raleigh, N Sever, PK Choksi, MA Sigg, KM Hines, BM Thompson, ...
Molecular cell 72 (2), 316-327. e5, 2018
452018
Endogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols
N Sever, RK Mann, L Xu, WJ Snell, CI Hernandez-Lara, NA Porter, ...
Proceedings of the National Academy of Sciences 113 (21), 5904-5909, 2016
382016
Simultaneous measurement of smoothened entry into and exit from the primary cilium
J Kim, EYC Hsia, J Kim, N Sever, PA Beachy, X Zheng
PloS one 9 (8), e104070, 2014
162014
Oxysterols are novel activators of hedgehog and Wnt signaling.
CM Amantea, JA Dwyer, N Sever, PA Beachy, W Kim, TJ Hahn, S Tetradis, ...
JOURNAL OF BONE AND MINERAL RESEARCH 21, S157-S157, 2006
52006
S6K2 promises an important therapeutic potential for cancer
Nİ Sever, S Cengiz Şahin
Future Oncology 15 (1), 95-102, 2019
22019
Mechanism of Lamellar Body Formation by Lung Surfactant Protein B
N Sever, G Miličić, NO Bodnar, X Wu, TA Rapoport
Molecular Cell, 2020
2020
Investigation of microRNAs which regulate S6K2 may enlighten new paths for breast cancer therapy
NI Sever, SC Sahin
FEBS OPEN BIO 9, 346-347, 2019
2019
Investigation of microRNAs which regulate S6K2 may enlighten new paths
NI Sever, SC Sahin
2019
Characterization of the ubiquitin ligase for S6K2 may overcome apoptotic barrier for breast and lung cancer cells
N Sever, SC Sahin
FEBS OPEN BIO 8, 319-320, 2018
2018
Characterization of the ubiquitin ligase for S6K2 may overcome apoptotic
N Sever, SC Sahin
WILEY, 2018
2018
EFFECTS OF APELIN LEVELS, APELIN GENE POLYMORPHISM AND APELIN RECEPTOR
D Keles, B Ozhan, F Altintas, B Akdag
WILEY, 2017
2017
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Articles 1–20