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Uwe Koch
Uwe Koch
Lead-Discovery-Center
Geverifieerd e-mailadres voor lead-discovery.de
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Characterization of CHO hydrogen bonds on the basis of the charge density
U Koch, PLA Popelier
The Journal of Physical Chemistry 99 (24), 9747-9754, 1995
29001995
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases
A Lahm, C Paolini, M Pallaoro, MC Nardi, P Jones, P Neddermann, ...
Proceedings of the National Academy of Sciences 104 (44), 17335-17340, 2007
5552007
Product inhibition of the hepatitis C virus NS3 protease
C Steinkühler, G Biasiol, M Brunetti, A Urbani, U Koch, R Cortese, A Pessi, ...
Biochemistry 37 (25), 8899-8905, 1998
2991998
Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site
S Di Marco, C Volpari, L Tomei, S Altamura, S Harper, F Narjes, U Koch, ...
Journal of Biological Chemistry 280 (33), 29765-29770, 2005
2022005
Discovery of MK-5172, a macrocyclic hepatitis C virus NS3/4a protease inhibitor
S Harper, JA McCauley, MT Rudd, M Ferrara, M DiFilippo, B Crescenzi, ...
ACS medicinal chemistry letters 3 (4), 332-336, 2012
1742012
Discovery of α, γ-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase
V Summa, A Petrocchi, P Pace, VG Matassa, R De Francesco, S Altamura, ...
Journal of medicinal chemistry 47 (1), 14-17, 2004
1692004
Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides
L Tomei, S Altamura, L Bartholomew, M Bisbocci, C Bailey, M Bosserman, ...
Journal of virology 78 (2), 938-946, 2004
1662004
A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease
F Narjes, KF Koehler, U Koch, B Gerlach, S Colarusso, C Steinkühler, ...
Bioorganic & medicinal chemistry letters 12 (4), 701-704, 2002
1662002
In vitro selection and characterization of hepatitis C virus serine protease variants resistant to an active-site peptide inhibitor
C Trozzi, L Bartholomew, A Ceccacci, G Biasiol, L Pacini, S Altamura, ...
Journal of Virology 77 (6), 3669-3679, 2003
1522003
2-(2-Thienyl)-5, 6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis
U Koch, B Attenni, S Malancona, S Colarusso, I Conte, M Di Filippo, ...
Journal of medicinal chemistry 49 (5), 1693-1705, 2006
1492006
Assessing different classification methods for virtual screening
D Plewczynski, SAH Spieser, U Koch
Journal of chemical information and modeling 46 (3), 1098-1106, 2006
1412006
Recent progress in the development of inhibitors of the hepatitis C virus RNA-dependent RNA polymerase
U Koch, F Narjes
Current topics in medicinal chemistry 7 (13), 1302-1329, 2007
1372007
BIGCHEM: challenges and opportunities for big data analysis in chemistry
IV Tetko, O Engkvist, U Koch, JL Reymond, H Chen
Molecular informatics 35 (11-12), 615-621, 2016
1032016
α-Ketoacids are potent slow binding inhibitors of the hepatitis C virus NS3 protease
F Narjes, M Brunetti, S Colarusso, B Gerlach, U Koch, G Biasiol, D Fattori, ...
Biochemistry 39 (7), 1849-1861, 2000
882000
Conformational dependence of atomic multipole moments
U Koch, PLA Popelier, AJ Stone
Chemical physics letters 238 (4-6), 253-260, 1995
821995
From dihydroxypyrimidine carboxylic acids to carboxamide HIV-1 integrase inhibitors: SAR around the amide moiety
A Petrocchi, U Koch, VG Matassa, B Pacini, KA Stillmock, V Summa
Bioorganic & Medicinal Chemistry Letters 17 (2), 350-353, 2007
782007
Structural characterization of the interactions of optimized product inhibitors with the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein by NMR and …
DO Cicero, G Barbato, U Koch, P Ingallinella, E Bianchi, MC Nardi, ...
Journal of molecular biology 289 (2), 385-396, 1999
771999
Evolution, synthesis and SAR of tripeptide α-ketoacid Inhibitors of the hepatitis C virus NS3/NS4A serine protease
S Colarusso, B Gerlach, U Koch, E Muraglia, I Conte, I Stansfield, ...
Bioorganic & medicinal chemistry letters 12 (4), 705-708, 2002
702002
Prime site binding inhibitors of a serine protease: NS3/4A of hepatitis C virus
P Ingallinella, D Fattori, S Altamura, C Steinkühler, U Koch, D Cicero, ...
Biochemistry 41 (17), 5483-5492, 2002
682002
Discovery of (7R)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a …
F Narjes, B Crescenzi, M Ferrara, J Habermann, S Colarusso, ...
Journal of medicinal chemistry 54 (1), 289-301, 2011
652011
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Artikelen 1–20