| Choosing the right tool for the job: RNAi, TALEN, or CRISPR M Boettcher, MT McManus Molecular cell 58 (4), 575-585, 2015 | 596 | 2015 |
| A mammosphere formation RNAi screen reveals that ATG4A promotes a breast cancer stem-like phenotype J Wolf, DL Dewi, J Fredebohm, K Müller-Decker, C Flechtenmacher, ... Breast cancer research 15, 1-13, 2013 | 144 | 2013 |
| Dual gene activation and knockout screen reveals directional dependencies in genetic networks M Boettcher, R Tian, JA Blau, E Markegard, RT Wagner, D Wu, X Mo, ... Nature biotechnology 36 (2), 170-178, 2018 | 140 | 2018 |
| Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation W Shang, Y Jiang, M Boettcher, K Ding, M Mollenauer, Z Liu, X Wen, ... Proceedings of the National Academy of Sciences 115 (17), E4051-E4060, 2018 | 94 | 2018 |
| Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton–Valentine leukocidin AT Tromp, M Van Gent, P Abrial, A Martin, JP Jansen, CJC De Haas, ... Nature microbiology 3 (6), 708-717, 2018 | 88 | 2018 |
| Bridge helix arginines play a critical role in Cas9 sensitivity to mismatches M Bratovič, I Fonfara, K Chylinski, EJC Gálvez, TJ Sullivan, S Boerno, ... Nature Chemical Biology 16 (5), 587-595, 2020 | 57 | 2020 |
| Establishment and characterization of a highly tumourigenic and cancer stem cell enriched pancreatic cancer cell line as a well defined model system J Fredebohm, M Boettcher, C Eisen, MM Gaida, A Heller, S Keleg, J Tost, ... PloS one 7 (11), e48503, 2012 | 45 | 2012 |
| Pooled RNAi screens-technical and biological aspects M Boettcher, JD Hoheisel Current genomics 11 (3), 162-167, 2010 | 39 | 2010 |
| An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation J Wolf, K Müller-Decker, C Flechtenmacher, F Zhang, M Shahmoradgoli, ... Oncogene 33 (33), 4273-4278, 2014 | 37 | 2014 |
| High-definition DNA methylation profiles from breast and ovarian carcinoma cell lines with differing doxorubicin resistance M Boettcher, F Kischkel, JD Hoheisel PloS one 5 (6), e11002, 2010 | 36 | 2010 |
| Depletion of RAD17 sensitizes pancreatic cancer cells to gemcitabine J Fredebohm, J Wolf, JD Hoheisel, M Boettcher Journal of cell science 126 (15), 3380-3389, 2013 | 35 | 2013 |
| Identification of X-chromosomal genes that drive sex differences in embryonic stem cells through a hierarchical CRISPR screening approach O Genolet, AA Monaco, I Dunkel, M Boettcher, EG Schulz Genome Biology 22, 1-41, 2021 | 33 | 2021 |
| High-throughput CRISPR screening identifies genes involved in macrophage viability and inflammatory pathways S Covarrubias, AC Vollmers, A Capili, M Boettcher, A Shulkin, MR Correa, ... Cell reports 33 (13), 2020 | 33 | 2020 |
| Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells M Berlak, E Tucker, M Dorel, A Winkler, A McGearey, E Rodriguez-Fos, ... Molecular Cancer 21 (1), 126, 2022 | 26 | 2022 |
| High throughput synthetic lethality screen reveals a tumorigenic role of adenylate cyclase in fumarate hydratase-deficient cancer cells M Boettcher, A Lawson, V Ladenburger, J Fredebohm, J Wolf, ... BMC genomics 15, 1-11, 2014 | 22 | 2014 |
| Tracing cellular heterogeneity in pooled genetic screens via multi-level barcoding M Boettcher, S Covarrubias, A Biton, J Blau, H Wang, N Zaitlen, ... BMC genomics 20, 1-9, 2019 | 20 | 2019 |
| Process for an efficient lentiviral cell transduction AC Pirona, R Oktriani, M Boettcher, JD Hoheisel Biology Methods and Protocols 5 (1), bpaa005, 2020 | 18 | 2020 |
| Decoding pooled RNAi screens by means of barcode tiling arrays M Boettcher, J Fredebohm, AM Gholami, Y Hachmo, I Dotan, D Canaani, ... BMC genomics 11, 1-16, 2010 | 18 | 2010 |
| Dissection of CD20 regulation in lymphoma using RNAi M Słabicki, KS Lee, A Jethwa, L Sellner, F Sacco, T Walther, J Hüllein, ... Leukemia 30 (12), 2409-2412, 2016 | 17 | 2016 |
| Host–Receptor Post-Translational Modifications Refine Staphylococcal Leukocidin Cytotoxicity AT Tromp, M Van Gent, JP Jansen, LM Scheepmaker, A Velthuizen, ... Toxins 12 (2), 106, 2020 | 8 | 2020 |
