| Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue CL Strickland, WT Windsor, R Syto, L Wang, R Bond, Z Wu, J Schwartz, ... Biochemistry 37 (47), 16601-16611, 1998 | 277 | 1998 |
| Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab G Scapin, X Yang, WW Prosise, M McCoy, P Reichert, JM Johnston, ... Nature structural & molecular biology 22 (12), 953-958, 2015 | 228 | 2015 |
| Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis G Scapin, VP Dandey, Z Zhang, W Prosise, A Hruza, T Kelly, T Mayhood, ... Nature 556 (7699), 122-125, 2018 | 206 | 2018 |
| Discovery of cyclic acylguanidines as highly potent and selective β-site amyloid cleaving enzyme (BACE) inhibitors: Part I Inhibitor design and validation Z Zhu, ZY Sun, Y Ye, J Voigt, C Strickland, EM Smith, J Cumming, L Wang, ... Journal of medicinal chemistry 53 (3), 951-965, 2010 | 165 | 2010 |
| Discovery of the 3-imino-1, 2, 4-thiadiazinane 1, 1-dioxide derivative verubecestat (MK-8931)–a β-site amyloid precursor protein cleaving enzyme 1 inhibitor for the treatment … JD Scott, SW Li, APJ Brunskill, X Chen, K Cox, JN Cumming, M Forman, ... Journal of medicinal chemistry 59 (23), 10435-10450, 2016 | 156 | 2016 |
| Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel μM leads for the development … YS Wang, C Strickland, JH Voigt, ME Kennedy, BM Beyer, MM Senior, ... Journal of medicinal chemistry 53 (3), 942-950, 2010 | 156 | 2010 |
| Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitor JN Cumming, EM Smith, L Wang, J Misiaszek, J Durkin, J Pan, U Iserloh, ... Bioorganic & medicinal chemistry letters 22 (7), 2444-2449, 2012 | 149 | 2012 |
| Mechanism of action and epitopes of Clostridium difficile toxin B-neutralizing antibody bezlotoxumab revealed by X-ray crystallography P Orth, L Xiao, LD Hernandez, P Reichert, PR Sheth, M Beaumont, ... Journal of biological chemistry 289 (26), 18008-18021, 2014 | 148 | 2014 |
| Heterocyclic aspartyl protease inhibitors Z Zhu, BA McKittrick, ZY Sun, CY Yuanzan, JH Voigt, C Strickland, ... US Patent 7,700,603, 2010 | 137 | 2010 |
| Discovery of the HCV NS3/4A Protease Inhibitor (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl … AJ Prongay, Z Guo, N Yao, J Pichardo, T Fischmann, C Strickland, ... Journal of medicinal chemistry 50 (10), 2310-2318, 2007 | 124 | 2007 |
| Tricyclic farnesyl protein transferase inhibitors: crystallographic and calorimetric studies of structure− activity relationships CL Strickland, PC Weber, WT Windsor, Z Wu, HV Le, MM Albanese, ... Journal of medicinal chemistry 42 (12), 2125-2135, 1999 | 113 | 1999 |
| Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase JA Ponasik, C Strickland, C Faerman, S Savvides, PA Karplus, B Ganem Biochemical Journal 311 (2), 371-375, 1995 | 106 | 1995 |
| Discovery of an orally available, brain penetrant BACE1 inhibitor that affords robust CNS Aβ reduction AW Stamford, JD Scott, SW Li, S Babu, D Tadesse, R Hunter, Y Wu, ... ACS medicinal chemistry letters 3 (11), 897-902, 2012 | 105 | 2012 |
| Potent pyrrolidine-and piperidine-based BACE-1 inhibitors U Iserloh, Y Wu, JN Cumming, J Pan, LY Wang, AW Stamford, ... Bioorganic & Medicinal Chemistry Letters 18 (1), 414-417, 2008 | 102 | 2008 |
| Crystal structure of the catalytic domain of human ADAM33 P Orth, P Reichert, W Wang, WW Prosise, T Yarosh-Tomaine, ... Journal of molecular biology 335 (1), 129-137, 2004 | 101 | 2004 |
| Charge is the major discriminating factor for glutathione reductase versus trypanothione reductase inhibitors CH Faerman, SN Savvides, C Strickland, MA Breidenbach, JA Ponasik, ... Bioorganic & Medicinal Chemistry 4 (8), 1247-1253, 1996 | 91 | 1996 |
| Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor U Iserloh, J Pan, AW Stamford, ME Kennedy, Q Zhang, L Zhang, ... Bioorganic & medicinal chemistry letters 18 (1), 418-422, 2008 | 89 | 2008 |
| Discovery of selective RNA-binding small molecules by affinity-selection mass spectrometry NF Rizvi, JA Howe, A Nahvi, DJ Klein, TO Fischmann, HY Kim, MA McCoy, ... ACS chemical biology 13 (3), 820-831, 2018 | 88 | 2018 |
| Beta-secretase crystals and methods for preparing and using the same B Beyer, G Hammond, P Reichert, C Strickland, W Wang, P Weber, ... US Patent App. 10/400,273, 2004 | 87 | 2004 |
| Heterocyclic aspartyl protease inhibitors Z Zhu, BA McKittrick, ZY Sun, CY Yuanzan, JH Voigt, C Strickland, ... US Patent 7,700,603, 2010 | 86 | 2010 |
