Efficient protection and isolation of ubiquitylated proteins using tandem ubiquitin‐binding entities R Hjerpe, F Aillet, F Lopitz‐Otsoa, V Lang, P England, MS Rodriguez EMBO reports 10 (11), 1250-1258, 2009 | 494 | 2009 |
UBQLN2 mediates autophagy-independent protein aggregate clearance by the proteasome R Hjerpe, JS Bett, MJ Keuss, A Solovyova, TG McWilliams, C Johnson, ... Cell 166 (4), 935-949, 2016 | 292 | 2016 |
Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes R Hjerpe, Y Thomas, J Chen, A Zemla, S Curran, N Shpiro, LR Dick, ... Biochemical Journal 441 (3), 927-939, 2012 | 129 | 2012 |
Heterologous SUMO-2/3-ubiquitin chains optimize IκBα degradation and NF-κB activity F Aillet, F Lopitz-Otsoa, I Egana, R Hjerpe, P Fraser, RT Hay, ... PloS one 7 (12), e51672, 2012 | 71 | 2012 |
NEDD8 overexpression results in neddylation of ubiquitin substrates by the ubiquitin pathway R Hjerpe, Y Thomas, T Kurz Journal of molecular biology 421 (1), 27-29, 2012 | 65 | 2012 |
Isolation of ubiquitylated proteins using tandem ubiquitin-binding entities F Aillet, F Lopitz-Otsoa, R Hjerpe, M Torres-Ramos, V Lang, ... Ubiquitin family modifiers and the proteasome: reviews and protocols, 173-183, 2012 | 46 | 2012 |
Unanchored tri‐NEDD8 inhibits PARP‐1 to protect from oxidative stress‐induced cell death MJ Keuss, R Hjerpe, O Hsia, R Gourlay, R Burchmore, M Trost, T Kurz The EMBO journal 38 (6), e100024, 2019 | 42 | 2019 |
Efficient approaches for characterizing ubiquitinated proteins R Hjerpe, MS Rodríguez Biochemical Society Transactions 36 (5), 823-827, 2008 | 41 | 2008 |
Sumoylation modulates the activity of Spalt-like proteins during wing development in Drosophila J Sánchez, A Talamillo, F Lopitz-Otsoa, C Pérez, R Hjerpe, JD Sutherland, ... Journal of biological chemistry 285 (33), 25841-25849, 2010 | 31 | 2010 |
Tetramerization-defects of p53 result in aberrant ubiquitylation and transcriptional activity V Lang, C Pallara, A Zabala, S Lobato-Gil, F Lopitz-Otsoa, R Farrás, ... Molecular oncology 8 (5), 1026-1042, 2014 | 29 | 2014 |
Alternative UPS drug targets upstream the 26S proteasome R Hjerpe, MS Rodríguez The international journal of biochemistry & cell biology 40 (6-7), 1126-1140, 2008 | 28 | 2008 |
Oligomerization conditions Mdm2-mediated efficient p53 polyubiquitylation but not its proteasomal degradation R Hjerpe, F Aillet, F Lopitz-Otsoa, V Lang, M Torres-Ramos, R Farrás, ... The international journal of biochemistry & cell biology 42 (5), 725-735, 2010 | 15 | 2010 |
SUMO and ubiquitin modifications during steroid hormone synthesis and function. A Talamillo, D Martín, R Hjerpe, J Sánchez, R Barrio Biochemical Society Transactions 38 (Pt 1), 54-59, 2010 | 11 | 2010 |
Ubiquitin binding polypeptides MSR Medina, R Hjerpe US Patent 8,716,441, 2014 | 6 | 2014 |
U1A is a positive regulator of the expression of heterologous and cellular genes involved in cell proliferation and migration E Rovira, B Moreno, N Razquin, R Hjerpe, M Gonzalez-Lopez, R Barrio, ... Molecular Therapy-Nucleic Acids 28, 831-846, 2022 | 1 | 2022 |
Abstract LB030: Building a platform of validated high throughput screening approaches for molecular glue degrader identification A Jordan, P Addis, T Allen, T Ayra, S Beck, R Brant, R Hjerpe, B Gourdet, ... Cancer Research 84 (7_Supplement), LB030-LB030, 2024 | | 2024 |
Breaking Bad Proteins—Discovery Approaches and the Road to Clinic for Degraders C Bouvier, R Lawrence, F Cavallo, W Xolalpa, A Jordan, R Hjerpe, ... Cells 13 (7), 578, 2024 | | 2024 |
Cryo-EM reveals important regulatory mechanism of the workhorses of targeted protein degradation R Hjerpe, T Kurz Molecular Cell 83 (13), 2159-2160, 2023 | | 2023 |
Beyond cereblon IMIDs-biophysics-based discovery of novel molecular glue chemotypes Y Zhang, J Bates, B Gourdet, L Birch, P Addis, R Hjerpe, AM Jordan Cancer Research 83 (7_Supplement), 3429-3429, 2023 | | 2023 |
The Sygnature CHARMD platform-combinatorial high-throughput assembly and review of molecular degraders R Hjerpe, L Birch, A Brien, L Cusin, L Duffy, B Gourdet, R Lawrence, ... Cancer Research 83 (7_Supplement), 3111-3111, 2023 | | 2023 |