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Stéphane Gangnard
Stéphane Gangnard
Verified email at pasteur.fr
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Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA
A Srivastava, S Gangnard, A Round, S Dechavanne, A Juillerat, B Raynal, ...
Proceedings of the National Academy of Sciences 107 (11), 4884-4889, 2010
1952010
Var2CSA minimal CSA binding region is located within the N-terminal region
A Srivastava, S Gangnard, S Dechavanne, F Amirat, A Lewit Bentley, ...
PloS one 6 (5), e20270, 2011
952011
Structure of a Plasmodium falciparum PfEMP1 rosetting domain reveals a role for the N-terminal segment in heparin-mediated rosette inhibition
A Juillerat, A Lewit-Bentley, M Guillotte, S Gangnard, A Hessel, B Baron, ...
Proceedings of the National Academy of Sciences 108 (13), 5243-5248, 2011
722011
VHH (nanobody) directed against human glycophorin A: A tool for autologous red cell agglutination assays
I Habib, D Smolarek, C Hattab, M Grodecka, G Hassanzadeh-Ghassabeh, ...
Analytical biochemistry 438 (1), 82-89, 2013
542013
Modifications of the charges at the N-terminus of bovine β-casein: Consequences on its structure and its micellisation
S Gangnard, Y Zuev, JC Gaudin, V Fedotov, Y Choiset, MAV Axelos, ...
Food Hydrocolloids 21 (2), 180-190, 2007
472007
Specific stimulation of HIV-1 replication in human placental trophoblasts by an antigen of Plasmodium falciparum
A Ayouba, C Badaut, A Kfutwah, C Cannou, A Juillerat, S Gangnard, ...
Aids 22 (6), 785-787, 2008
372008
Biochemical and biophysical characterisation of DBL1α1-varO, the rosetting domain of PfEMP1 from the VarO line of Plasmodium falciparum
A Juillerat, S Igonet, I Vigan-Womas, M Guillotte, S Gangnard, G Faure, ...
Molecular and biochemical parasitology 170 (2), 84-92, 2010
352010
Structure of the DBL3X-DBL4ε region of the VAR2CSA placental malaria vaccine candidate: insight into DBL domain interactions
S Gangnard, A Lewit-Bentley, S Dechavanne, A Srivastava, F Amirat, ...
Scientific reports 5 (1), 14868, 2015
342015
Parity-dependent recognition of DBL1X-3X suggests an important role of the VAR2CSA high-affinity CSA-binding region in the development of the humoral response against placental …
S Dechavanne, A Srivastava, S Gangnard, S Nunes-Silva, C Dechavanne, ...
Infection and immunity 83 (6), 2466-2474, 2015
332015
Down-selection of the VAR2CSA DBL1-2 expressed in E. coli as a lead antigen for placental malaria vaccine development
A Chêne, S Gangnard, C Dechavanne, S Dechavanne, A Srivastava, ...
NPJ vaccines 3 (1), 28, 2018
302018
Structural and immunological correlations between the variable blocks of the VAR2CSA domain DBL6ε from two Plasmodium falciparum parasite lines
S Gangnard, C Badaut, S Ramboarina, B Baron, T Ramdani, B Gamain, ...
Journal of molecular biology 425 (10), 1697-1711, 2013
292013
Preclinical immunogenicity and safety of the cGMP-grade placental malaria vaccine PRIMVAC
A Chêne, S Gangnard, A Guadall, H Ginisty, O Leroy, N Havelange, ...
EBioMedicine 42, 145-156, 2019
282019
Insight into Antigenic Diversity of VAR2CSA-DBL5ε Domain from Multiple Plasmodium falciparum Placental Isolates
S Gnidehou, L Jessen, S Gangnard, C Ermont, C Triqui, M Quiviger, ...
PLoS One 5 (10), e13105, 2010
222010
Llama immunization with full-length VAR2CSA generates cross-reactive and inhibitory single-domain antibodies against the DBL1X domain
S Nunes-Silva, S Gangnard, M Vidal, A Vuchelen, S Dechavanne, S Chan, ...
Scientific reports 4 (1), 7373, 2014
212014
Beninese children with cerebral malaria do not develop humoral immunity against the IT4-VAR19-DC8 PfEMP1 variant linked to EPCR and brain endothelial binding
S Nunes-Silva, S Dechavanne, A Moussiliou, N Pstrąg, JP Semblat, ...
Malaria journal 14, 1-15, 2015
202015
Functional and immunological characterization of the var2CSA-DBL5ɛ domain of a placental Plasmodium falciparum isolate
S Gangnard, NGT Ndam, S Gnidehou, M Quiviger, A Juillerat, G Faure, ...
Molecular and biochemical parasitology 173 (2), 115-122, 2010
162010
Phosphorylation of the VAR2CSA extracellular region is associated with enhanced adhesive properties to the placental receptor CSA
D Dorin-Semblat, M Tétard, A Claës, JP Semblat, S Dechavanne, ...
PLoS biology 17 (6), e3000308, 2019
152019
Murine model for preclinical studies of var2csa-mediated pathology associated with malaria in pregnancy
LV de Moraes, S Dechavanne, PM Sousa, A Barateiro, SF Cunha, ...
Infection and Immunity 84 (6), 1761-1774, 2016
142016
VAR2CSA binding phenotype has ancient origin and arose before Plasmodium falciparum crossed to humans: implications in placental malaria vaccine design
S Gangnard, A Chêne, S Dechavanne, A Srivastava, M Avril, JD Smith, ...
Scientific Reports 9 (1), 16978, 2019
42019
A nanobody against the VWF A3 domain detects ADAMTS13-induced proteolysis in congenital and acquired VWD
C Kizlik-Masson, I Peyron, S Gangnard, G Le Goff, SM Lenoir, ...
Blood 141 (12), 1457-1468, 2023
32023
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