Lucía Chávez-Gutiérrez
Lucía Chávez-Gutiérrez
University of Leuven / VIB Center for Brain & Disease Research
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The mechanism of γ‐secretase dysfunction in familial Alzheimer disease
L Chávez‐Gutiérrez, L Bammens, I Benilova, A Vandersteen, M Benurwar, ...
The EMBO journal 31 (10), 2261-2274, 2012
LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis
S Matta, K Van Kolen, R da Cunha, G van den Bogaart, W Mandemakers, ...
Neuron 75 (6), 1008-1021, 2012
Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the γ-secretase complex
A Tolia, L Chávez-Gutiérrez, B De Strooper
Journal of Biological Chemistry 281 (37), 27633-27642, 2006
Glu332 in the nicastrin ectodomain is essential for γ-secretase complex maturation but not for its activity
L Chávez-Gutiérrez, A Tolia, E Maes, T Li, PC Wong, B De Strooper
Journal of Biological Chemistry 283 (29), 20096-20105, 2008
Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond
B De Strooper, L Chávez Gutiérrez
Annual review of pharmacology and toxicology 55, 419-437, 2015
Alzheimer’s-causing mutations shift Aβ length by destabilizing γ-secretase-Aβn interactions
M Szaruga, B Munteanu, S Lismont, S Veugelen, K Horré, M Mercken, ...
Cell 170 (3), 443-456. e14, 2017
Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer’s disease: a case series
NS Ryan, JM Nicholas, PSJ Weston, Y Liang, T Lashley, R Guerreiro, ...
The Lancet Neurology 15 (13), 1326-1335, 2016
Qualitative changes in human γ-secretase underlie familial Alzheimer’s disease
M Szaruga, S Veugelen, M Benurwar, S Lismont, D Sepulveda-Falla, ...
Journal of Experimental Medicine 212 (12), 2003-2013, 2015
Familial Alzheimer’s disease mutations in presenilin generate amyloidogenic Aβ peptide seeds
S Veugelen, T Saito, TC Saido, L Chávez-Gutiérrez, B De Strooper
Neuron 90 (2), 410-416, 2016
Signature amyloid β profiles are produced by different γ-secretase complexes
H Acx, L Chávez-Gutiérrez, L Serneels, S Lismont, M Benurwar, N Elad, ...
Journal of Biological Chemistry 289 (7), 4346-4355, 2014
Modification of γ‐secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease
FX Guix, T Wahle, K Vennekens, A Snellinx, L Chávez‐Gutiérrez, ...
EMBO molecular medicine 4 (7), 660-673, 2012
The dynamic conformational landscape of γ-secretase
N Elad, B De Strooper, S Lismont, W Hagen, S Veugelen, M Arimon, ...
Journal of cell science 128 (3), 589-598, 2015
Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP
FK Wiseman, LJ Pulford, C Barkus, F Liao, E Portelius, R Webb, ...
Brain 141 (8), 2457-2474, 2018
Inhibition of β-secretase in vivo via antibody binding to unique loops (D and F) of BACE1
L Zhou, L Chávez-Gutiérrez, K Bockstael, R Sannerud, W Annaert, ...
Journal of Biological Chemistry 286 (10), 8677-8687, 2011
Functional and topological analysis of Pen-2, the fourth subunit of the γ-secretase complex
L Bammens, L Chávez-Gutiérrez, A Tolia, A Zwijsen, B De Strooper
Journal of Biological Chemistry 286 (14), 12271-12282, 2011
Genetic determinants of white matter hyperintensities and amyloid angiopathy in familial Alzheimer's disease
NS Ryan, GJ Biessels, L Kim, JM Nicholas, PA Barber, P Walsh, P Gami, ...
Neurobiology of aging 36 (12), 3140-3151, 2015
Modulation of γ-and β-secretases as early prevention against Alzheimer’s disease
I Voytyuk, B De Strooper, L Chávez-Gutiérrez
Biological psychiatry 83 (4), 320-327, 2018
Inactivation of γ‐secretases leads to accumulation of substrates and non‐Alzheimer neurodegeneration
H Acx, L Serneels, E Radaelli, S Muyldermans, C Vincke, E Pepermans, ...
EMBO molecular medicine 9 (8), 1088-1099, 2017
Deletion of exons 9 and 10 of the Presenilin 1 gene in a patient with Early-onset Alzheimer Disease generates longer amyloid seeds
K Le Guennec, S Veugelen, O Quenez, M Szaruga, S Rousseau, ...
Neurobiology of disease 104, 97-103, 2017
Homology modeling and site-directed mutagenesis of pyroglutamyl peptidase II: insights into omega-versus aminopeptidase specificity in the M1 family
L Chávez-Gutiérrez, E Matta-Camacho, J Osuna, E Horjales, ...
Journal of Biological Chemistry 281 (27), 18581-18590, 2006
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